Thermal fields during welding and their analogues

Summary available: p. [5

Urinary biomarkers for renal tract malformations

Introduction: Renal tract malformations (RTMs) are congenital anomalies of the kidneys and urinary tract, which are the major cause of end-stage renal disease in children. Using immunoassay-based approaches (ELISA, western blot), individual urinary proteins including transforming growth factor β, tumor necrosis factor and monocyte attractant proteins 1 were found to be associated to RTMs. However, only mass spectrometry (MS) based methods leading to the identification of panels of protein-based markers composed of fragments of the extracellular matrix allowed the prediction of progression of RTMs and its complications. Areas covered: In this review, we summarized relevant studies identified in “Pubmed” using the keywords “urinary biomarkers” and “proteomics” and “renal tract malformations” or “hydronephrosis” or “ureteropelvic junction obstruction” or “posterior urethral valves” or “vesicoureteral reflux”. These publications represent studies on potential protein-based biomarkers, either individually or combined in panels, of RTMs in human and animal models. Expert commentary: Successful use in the clinic of these protein-based biomarkers will need to involve larger scale studies to reach sufficient power. Improved performance will potentially come from combining immunoassay- and MS-based markers

The scope of climate assemblies: lessons from the Climate Assembly UK

In recent times we have seen a spate of climate assemblies across Europe as the climate emergency gains increasing prominence in the political agenda and as the citizens’ assembly approach to public engagement gains popularity. However, there has been little empirical research on how the scope of citizens’ assemblies affects the internal logic of the assembly process and its impacts on external policy actors. This is a significant oversight given the power of agenda setting. It is also of particular importance for climate assemblies given the exceptional scale and complexity of climate change, as well as the need for co-ordination across all policy areas and types of governance to address it. In this paper, we start to address this gap through an in-depth case analysis of the Climate Assembly UK. We adopt a mixed methods approach, combining surveys of the assembly members and witnesses, interviews with the assembly members, organisers, MPs, parliamentary staff, and government civil servants, and non-participant observation of the process. We find that attempts to adapt the assembly’s scope to the scale of the climate change issue compromised assembly member learning, the co-ordination of the resulting recommendations, assembly member endorsement of the recommendations, and the extent of their impact on parliament and government. We argue that more democratization in setting the agenda could help combat these issues

Vertical smooth pursuit as a diagnostic marker of traumatic brain injury.

AIM: Neural deficits were measured via the eye tracking of vertical smooth pursuit (VSP) as markers of traumatic brain injury (TBI). The present study evaluated the ability of the eye tracking tests to differentiate between different levels of TBI severity and healthy controls. METHODOLOGY: Ninety-two individuals divided into four groups (those with mild, moderate or severe TBI and healthy controls) participated in a computerized test of VSP eye movement using a remote eye tracker. RESULTS: The VSP eye tracking test was able to distinguish between severe and moderate levels of TBI but unable to detect differences in the performance of participants with mild TBI and healthy controls. CONCLUSION: The eye-tracking technology used to measure VSP eye movements is able to provide a timely and objective method of differentiating between individuals with moderate and severe levels of TBI

International perspectives of nurses, midwives and allied health professionals clinical academic roles: Are we at tipping point?

© 2019 Debbie Carrick-Sen, Ann Moore, Patricia Davidson, Han Gendong, & Debra Jackson. Healthcare research activity improves patient outcomes. Nurses, Midwives and Allied Health Professions (NMAHPs) make an important contribution to clinical research. Within the United Kingdom (UK), there is a 25-year history of increasing healthcare research capacity and capability through clinical academic roles. Medical colleagues were the first to introduce the role in 2005. In 2007, a national policy identified inequalities in access to and success of research training fellowships between medical and nursing healthcare professionals. This was followed by a number of national initiatives, which continue to evolve to the present day. There is evidence that the UK has reached the 'tipping point' to increase NMAHP research capacity and capability through clinical academic roles. Despite these initiatives substantial gaps remain. Outside, the UK, the term 'clinical academic' is not well understood. There is evidence of the presence of senior clinical academic roles, a clinical professor within Australia and the United States, for example, but there is a lack of opportunities and of a formulised research training pathway at a junior level. There is interest and appreciation of the NMAHP research-active clinical academic within the clinical setting in the Nordic countries and China, but the pace of change is slow due to co-existing priorities involving change and innovation. There is a need to develop and agree both national and international definitions that describes the NMAHP research-focused clinical academic role activity