1 research outputs found
Immunosuppressive Acidic Protein- Haematological correlates in HIV infected subjects
Background:
Immunosuppressive Acidic protein (IAP) is a marker of the extent of
immune defects occurring in most cancers. Its correlation with CD4 cell count used as an
indicator of immune function and disease progression in Human Immuno-deficiency Virus
(HIV) infection is not well documented.
Aims and Objectives:
To determine if IAP levels
correlates with immunosupression and haematopathology occurring in HIV/AIDS infection.
Materials and Methods:
This cross sectional study was conducted at the Federal Teaching
Hospital, Ido-Ekiti. One hundred and five participants consisting of 85 HIV infected test
subjects and 20 control subjects were enrolled into the study. CD4 counts was obtained
using SL Cyflow machine, IAP levels determined using ELISA kit for human IAP and Full
blood count for all participants was obtained using Sysmex KX-21N Haematology Analyzer.
Regression and correlation analysis was done on data using SPSS 28.
Results:
IAP showed
a negative correlation with CD4 count (r=
-0.6), (r=
-0.9) and (r=
-0.2) in the ART, NART
and control groups. The pattern of the results was similar with other parameters except in
Neutrophils (r= 0.2) (r= 0.3) and (0.1), Eosinophil (r= 0.6) (r=
-0.4) and (r=
-0.2) and
Lymphocyte (r =
-0.3) (r=
-0.02) and (r= 0.05) in the ART, NART and control groups
respectively.
Conclusion:
The outcome of this study show that a strong negative relationship
exist between IAP and other immunohaematological parameters used for monitoring Immune
status in HIV infection; however the information gotten is not sufficient to indicate IAP as a
predictor of immune status in HIV infection. Further studies are therefore required to better
elucidate the mechanism of increased IAP levels at different clinical stages of HIV infection