Somatomotor-Visual Resting State Functional Connectivity Increases After Two Years in the UK Biobank Longitudinal Cohort

Functional magnetic resonance imaging (fMRI) and functional connectivity (FC) have been used to follow aging in both children and older adults. Robust changes have been observed in children, where high connectivity among all brain regions changes to a more modular structure with maturation. In older adults, prior work has identified changes in connectivity associated with the default mode network (DMN); other work has used brain age to predict pre-clinical Alzheimer's disease. In this work, we find an increasing connectivity between the Somatomotor (SMT) and Visual (VIS) Networks using the Power264 atlas in a longitudinal cohort of the UK Biobank (UKB). This cohort consists of 2,722 subjects, with scans being taken an average of two years apart. The average connectivity increase between SMT-VIS is 6.8% compared to the younger scan baseline (from $\rho=0.39$ to $\rho=0.42$), and occurs in male, female, older subject ($>65$ years old), and younger subject ($<55$ years old) groups. Among all inter-network connections, this average SMT-VIS connectivity is the best predictor of relative scan age, accurately predicting which scan is older 57% of the time. Using the full FC and a training set of 2,000 subjects, one is able to predict which scan is older 82.5% of the time when using the difference of FC between the two scans as input to a classifier. This previously under-reported relationship may shed light on normal changes in aging brain FC, identifies a potential confound for longitudinal studies, and proposes a new area for investigation, specifically the SMT-VIS connectivity.Comment: 12 pages, 10 figures, 3 table

Latent Similarity Identifies Important Functional Connections for Phenotype Prediction

Objective: Endophenotypes such as brain age and fluid intelligence are important biomarkers of disease status. However, brain imaging studies to identify these biomarkers often encounter limited numbers of subjects and high dimensional imaging features, hindering reproducibility. Therefore, we develop an interpretable, multivariate classification/regression algorithm, called Latent Similarity (LatSim), suitable for small sample size, high feature dimension datasets. Methods: LatSim combines metric learning with a kernel similarity function and softmax aggregation to identify task-related similarities between subjects. Inter-subject similarity is utilized to improve performance on three prediction tasks using multi-paradigm fMRI data. A greedy selection algorithm, made possible by LatSim's computational efficiency, is developed as an interpretability method. Results: LatSim achieved significantly higher predictive accuracy at small sample sizes on the Philadelphia Neurodevelopmental Cohort (PNC) dataset. Connections identified by LatSim gave superior discriminative power compared to those identified by other methods. We identified 4 functional brain networks enriched in connections for predicting brain age, sex, and intelligence. Conclusion: We find that most information for a predictive task comes from only a few (1-5) connections. Additionally, we find that the default mode network is over-represented in the top connections of all predictive tasks. Significance: We propose a novel algorithm for small sample, high feature dimension datasets and use it to identify connections in task fMRI data. Our work should lead to new insights in both algorithm design and neuroscience research. Code and demo are available at https://github.com/aorliche/LatentSimilarity/.Comment: 12 page

Developing a document Control Sytem (Semester Unknown) IPRO 347: Developing a document Control Sytem IPRO 347Project Plan Su08

The IPRO 347 team is being sponsored by Abrasive Form to lead the company into a paperless form of tracking projects. Abrasive Form currently uses a paper folder, which they call the “job folder” to hold all the important documents for completing incoming projects. This job folder travels along with the pieces of the project until the project is completed. Once a project has been completed, and the final product is shipped out, the job folder for that project is then kept in an on-site filling cabinet. So far this has led to several problems for Abrasive Form. As the company is increasing in size and completing increasing amounts of projects, they have had to dedicate a large portion of their offices to the storing of old job files. Abrasive Form keeps all of their completed job folders to ensure that all liability for the company is covered, and whenever necessary throughout the lifespan of completed projects in the field, Abrasive Form is able to prove that their work was of the quality that was requested. This has also lead to a lot of time being wasted by the employees of Abrasive Form traveling to the back offices where the job folders are held to look up information. The IPRO 347 team will be helping Abrasive Form come up with a solution to this very serious problem. The solution generated thus far is to scan all the documents contained within the paper job folders into PDF form, and use a digital filing program (such as Bugzilla which is a free open source program) to organize the PDF files into sub folders, and allow for quick referencing based on critical criteria such as the job number, part number, customer name, or part number. All this information would then be contained in a single server that can be accessed on any computer throughout the company through an internal network.Sponsorship: Abrasive-FormDeliverable

Developing a document Control Sytem (Semester Unknown) IPRO 347: Developing a document Control Sytem IPRO 347 Final Report Su08

The IPRO 347 team is being sponsored by Abrasive Form to lead the company into a paperless form of tracking projects. Abrasive Form currently uses a paper folder, which they call the “job folder” to hold all the important documents for completing incoming projects. This job folder travels along with the pieces of the project until the project is completed. Once a project has been completed, and the final product is shipped out, the job folder for that project is then kept in an on-site filling cabinet. So far this has led to several problems for Abrasive Form. As the company is increasing in size and completing increasing amounts of projects, they have had to dedicate a large portion of their offices to the storing of old job files. Abrasive Form keeps all of their completed job folders to ensure that all liability for the company is covered, and whenever necessary throughout the lifespan of completed projects in the field, Abrasive Form is able to prove that their work was of the quality that was requested. This has also lead to a lot of time being wasted by the employees of Abrasive Form traveling to the back offices where the job folders are held to look up information. The IPRO 347 team will be helping Abrasive Form come up with a solution to this very serious problem. The solution generated thus far is to scan all the documents contained within the paper job folders into PDF form, and use a digital filing program (such as Bugzilla which is a free open source program) to organize the PDF files into sub folders, and allow for quick referencing based on critical criteria such as the job number, part number, customer name, or part number. All this information would then be contained in a single server that can be accessed on any computer throughout the company through an internal network.Sponsorship: Abrasive-FormDeliverable

Developing a document Control Sytem (Semester Unknown) IPRO 347

The IPRO 347 team is being sponsored by Abrasive Form to lead the company into a paperless form of tracking projects. Abrasive Form currently uses a paper folder, which they call the “job folder” to hold all the important documents for completing incoming projects. This job folder travels along with the pieces of the project until the project is completed. Once a project has been completed, and the final product is shipped out, the job folder for that project is then kept in an on-site filling cabinet. So far this has led to several problems for Abrasive Form. As the company is increasing in size and completing increasing amounts of projects, they have had to dedicate a large portion of their offices to the storing of old job files. Abrasive Form keeps all of their completed job folders to ensure that all liability for the company is covered, and whenever necessary throughout the lifespan of completed projects in the field, Abrasive Form is able to prove that their work was of the quality that was requested. This has also lead to a lot of time being wasted by the employees of Abrasive Form traveling to the back offices where the job folders are held to look up information. The IPRO 347 team will be helping Abrasive Form come up with a solution to this very serious problem. The solution generated thus far is to scan all the documents contained within the paper job folders into PDF form, and use a digital filing program (such as Bugzilla which is a free open source program) to organize the PDF files into sub folders, and allow for quick referencing based on critical criteria such as the job number, part number, customer name, or part number. All this information would then be contained in a single server that can be accessed on any computer throughout the company through an internal network.Sponsorship: Abrasive-FormDeliverable

Developing a document Control Sytem (Semester Unknown) IPRO 347: Developing a document Control Sytem IPRO 347 Abstract Su08

The IPRO 347 team is being sponsored by Abrasive Form to lead the company into a paperless form of tracking projects. Abrasive Form currently uses a paper folder, which they call the “job folder” to hold all the important documents for completing incoming projects. This job folder travels along with the pieces of the project until the project is completed. Once a project has been completed, and the final product is shipped out, the job folder for that project is then kept in an on-site filling cabinet. So far this has led to several problems for Abrasive Form. As the company is increasing in size and completing increasing amounts of projects, they have had to dedicate a large portion of their offices to the storing of old job files. Abrasive Form keeps all of their completed job folders to ensure that all liability for the company is covered, and whenever necessary throughout the lifespan of completed projects in the field, Abrasive Form is able to prove that their work was of the quality that was requested. This has also lead to a lot of time being wasted by the employees of Abrasive Form traveling to the back offices where the job folders are held to look up information. The IPRO 347 team will be helping Abrasive Form come up with a solution to this very serious problem. The solution generated thus far is to scan all the documents contained within the paper job folders into PDF form, and use a digital filing program (such as Bugzilla which is a free open source program) to organize the PDF files into sub folders, and allow for quick referencing based on critical criteria such as the job number, part number, customer name, or part number. All this information would then be contained in a single server that can be accessed on any computer throughout the company through an internal network.Sponsorship: Abrasive-FormDeliverable

Developing a document Control Sytem (Semester Unknown) IPRO 347: Developing a document Control Sytem IPRO 347 Poster Su08

The IPRO 347 team is being sponsored by Abrasive Form to lead the company into a paperless form of tracking projects. Abrasive Form currently uses a paper folder, which they call the “job folder” to hold all the important documents for completing incoming projects. This job folder travels along with the pieces of the project until the project is completed. Once a project has been completed, and the final product is shipped out, the job folder for that project is then kept in an on-site filling cabinet. So far this has led to several problems for Abrasive Form. As the company is increasing in size and completing increasing amounts of projects, they have had to dedicate a large portion of their offices to the storing of old job files. Abrasive Form keeps all of their completed job folders to ensure that all liability for the company is covered, and whenever necessary throughout the lifespan of completed projects in the field, Abrasive Form is able to prove that their work was of the quality that was requested. This has also lead to a lot of time being wasted by the employees of Abrasive Form traveling to the back offices where the job folders are held to look up information. The IPRO 347 team will be helping Abrasive Form come up with a solution to this very serious problem. The solution generated thus far is to scan all the documents contained within the paper job folders into PDF form, and use a digital filing program (such as Bugzilla which is a free open source program) to organize the PDF files into sub folders, and allow for quick referencing based on critical criteria such as the job number, part number, customer name, or part number. All this information would then be contained in a single server that can be accessed on any computer throughout the company through an internal network.Sponsorship: Abrasive-FormDeliverable

Developing a document Control Sytem (Semester Unknown) IPRO 347: Developing a document Control Sytem IPRO 347 Final Presentation Su08

The IPRO 347 team is being sponsored by Abrasive Form to lead the company into a paperless form of tracking projects. Abrasive Form currently uses a paper folder, which they call the “job folder” to hold all the important documents for completing incoming projects. This job folder travels along with the pieces of the project until the project is completed. Once a project has been completed, and the final product is shipped out, the job folder for that project is then kept in an on-site filling cabinet. So far this has led to several problems for Abrasive Form. As the company is increasing in size and completing increasing amounts of projects, they have had to dedicate a large portion of their offices to the storing of old job files. Abrasive Form keeps all of their completed job folders to ensure that all liability for the company is covered, and whenever necessary throughout the lifespan of completed projects in the field, Abrasive Form is able to prove that their work was of the quality that was requested. This has also lead to a lot of time being wasted by the employees of Abrasive Form traveling to the back offices where the job folders are held to look up information. The IPRO 347 team will be helping Abrasive Form come up with a solution to this very serious problem. The solution generated thus far is to scan all the documents contained within the paper job folders into PDF form, and use a digital filing program (such as Bugzilla which is a free open source program) to organize the PDF files into sub folders, and allow for quick referencing based on critical criteria such as the job number, part number, customer name, or part number. All this information would then be contained in a single server that can be accessed on any computer throughout the company through an internal network.Sponsorship: Abrasive-FormDeliverable

A Video Annotation and Indexing System (sequence unknown), IPRO 327 - Deliverables: IPRO 327 IPRO Day Presentation F09

Much information available on the Web is in video format. The problem with this medium is users cannot comment on particular scenes within the videos and there is no method of searching for specific content within the videos. The team proposes to develop a system that will allow users to make fine-grained comments on scenes within the video and then to use these comments to aid in search within videos.Deliverables for IPRO 327: A video annotation and indexing system for the fall 2009 semeste

A Video Annotation and Indexing System (sequence unknown), IPRO 327 - Deliverables: IPRO 327 Final Report F09

Much information available on the Web is in video format. The problem with this medium is users cannot comment on particular scenes within the videos and there is no method of searching for specific content within the videos. The team proposes to develop a system that will allow users to make fine-grained comments on scenes within the video and then to use these comments to aid in search within videos.Deliverables for IPRO 327: A video annotation and indexing system for the fall 2009 semeste