Importance of local renin-angiotensin systems and anti-ischemic effects of ACE-inhibitors in patients with coronary artery disease.

Part I of this thesis discusses the imporlance of the circulating and tissue localized reninangiotensin system. Although tissue or local ACE seems quantitatively and qualitatrvely far more important than circulating or plasma ACE, elevated plasma ACE activify is shown to be a significant and independent predrictor of the development of left ventricular dilation after myocardial infarction ... Zie: Chapter 1