The Effects Of Combination Of Behavioural Intervention, Nutritional Education And Exercise (Combine) Program On Haemostatic Markers Among Obese Subjects

Obesity is a condition of excess body fat and it significantly increases the risk of coronary heart disease. Studies have shown that impaired haemostatic in obesity were found to predict future development of coronary heart disease and numbers of coronary events. The purpose of this study was to determine the effects of COMBINE program on the changes of anthropometry parameters, biochemical profile and haemostatic markers in obese subjects. The assessment was carried out on 28 obese subjects for 12-week duration. All subjects were required to give an informed consent before enrolling into the study

Augmented reality (AR) and virtual reality (VR) applications during Covid-19 pandemic among preclinical medical and dentistry students: a mini-review

The efficacy of online learning in delivering theoretical knowledge with appropriate content to students is imperative, especially in the Covid-19 pandemic era. Substantial interactive teaching materials were developed for higher education. However, some were designed immensely general, especially in fulfilling the syllabus of preclinical medical and dentistry students. Augmented reality (AR) is an interactive three-dimension (3D) experience that uses computers to overlay virtual information in the real world whereas virtual reality (VR) is a computer-generated artificial recreation of a real-life experience or situation. Interestingly, both can be complemented and integrated into online and traditional teaching methods. Implementation of these technologies will increase the learning efficacy in understanding the human body’s anatomical and physiological changes in the normal or pathological state. As AR and VR technologies are continuously evolving, this review provides the preview and current updates on AR and VR applications in medical and dentistry education which may benefit the educators within these specialities

Centella asiatica (L.) Urb: A comprehensive bibliometric analysis of published studies between 1857 and 2022

Centella asiatica (L.) Urban (C. asiatica) is a medicinal plant that generates terpenes, phenols, vitamins, minerals, polyacetylene and fatty acids among other phyto-constituents. This review focuses on the bibliometric analysis of 1164 documents on C. asiatica that were retrieved from the Scopus database. Harzing Publish or Perish and VOSviewer were used for citation and network analyses. According to the bibliometric analysis, publications are on the rise, particularly in the fields of pharmacology, toxicology and pharmaceutics, medicine, biochemistry, genetics and molecular biology, agricultural and biological sciences, and chemistry. "Phytoremediation", "secondary metabolites", "Andrographis paniculata", and "cognitive impairment" are emerging areas for C. asiatica research. However, currently there is a lack of international collaboration in C. asiatica research among contributing countries. Researchers can utilise the findings cited in this reiew to locate potential collaborators, top authors, countries and documents

Brain-derived neurotrophic factor (BDNF) in schizophrenia research: a quantitative review and future directions

This review aims to perform a bibliometric analysis of the research related to brain-derived neurotrophic factor (BDNF) in schizophrenia and offer suggestions for further work. Based on the keywords used, our study retrieved 335 documents for further analysis using a combination of three bibliometric techniques: co-word analysis, document co-citation analysis, and bibliographic coupling. A general rising trend in the number of publications was found in BDNF and schizophrenia research. Researchers from China and the United States have mostly researched BDNF and schizophrenia. Molecular Psychiatry is the most prestigious journal in the field of BDNF and schizophrenia research. The main topics and important research areas are cognition and the involvement of BDNF as a neurobiological marker (pathogenesis, therapy monitoring, and risk factors). Future research is anticipated to concentrate on relevant subjects, such as factors that affect BDNF levels or are connected to BDNF dysfunction in schizophrenia, as well as animal models of schizophrenia, in addition to cognition in schizophrenia

Association between level of knowledge gained, confidence, motivation and flexibility on types of learning for bedside teaching among clinical students in four Malaysian medical schools during Covid-19 pandemic

Introduction: With the arise of the COVID-19 pandemic, higher institutions are forced to change the method of delivery for bedside teaching sessions from face-to-face to online learning. However, online learning was found not effective in delivering practical knowledge and skills to students. Hence, the objective of this study was to determine the association between level of knowledge gained, confidence, motivation and flexibility on types of learning for bedside teaching sessions among clinical students in four Malaysian medical schools during COVID-19 pandemic. Methods: A cross-sectional study involving medical students from Universiti Putra Malaysia (UPM), Universiti Sains Islam Malaysia (USIM), Universiti Islam Antarabangsa (UIA) and Universiti Sains Malaysia (USM) were conducted from 1st March 2021 until 6th June 2021. An online questionnaire was distributed and it consisted of 5 sections which cover sociodemographic information, level of knowledge gained, confidence, motivation, and flexibility from bedside teaching session. The data was analysed by using SPSS software program. Results: There is a significant association between the level of knowledge gained, level of confidence, level of motivation and level of flexibility with the type of learning (online or face-to-face) during bedside teaching sessions. Results revealed that students gained a higher level of knowledge (84.9%), higher level of confidence in physical examination (93.3%), higher motivation (82.2%) and higher flexibility (64.1%) during face-to-face bedside teaching sessions compared to online learning. Conclusion: Most of the medical students in four Malaysian medical schools prefer face-to-face learning compared to online learning for bedside teaching session

Association between the level of knowledge, awareness and attitude on post-COVID-19 syndrome amongst medical students in four Malaysian universities

Introduction: COVID-19 is a respiratory illness that is caused by a coronavirus. Infected people will have a chance to develop post-COVID-19 syndrome. The aim of this study is to identify the association of gender, marital status, age and university on knowledge, awareness and attitude of post-COVID-19 syndrome among medical students in four universities in Malaysia. Methods: A cross-sectional study was conducted from October 2021 to July 2022 at four universities in Malaysia which are Universiti Putra Malaysia (UPM), Universiti Islam Antarabangsa Malaysia (UIAM), Universiti Sains Malaysia (USM) and Universiti Sains Islam Malaysia (USIM). A self-administered questionnaire was administered to 355 respondents consisted of four sections, assessing socio-demographic data and knowledge, awareness and attitudes of post-COVID-19 syndrome. Results: 54.4% of the respondents had high knowledge, 53.8% had high awareness, and 55.21% had a high attitude towards post-COVID-19 syndrome. In this study, there is a significant association between knowledge on post-COVID-19 syndrome and the age among respondents. Knowledge and awareness, knowledge, and attitude as well as awareness and attitude on post-COVID-19 syndrome was also found to have significant association among respondents. Conclusion: The older age of the respondents have good knowledge towards post-COVID-19 syndrome

Association between the level of knowledge, awareness, and attitude on post-COVID-19 syndrome amongst medical students in four Malaysian universities

Introduction: COVID-19 is a respiratory illness that is caused by a coronavirus. Infected people will have a chance to develop post-COVID-19 syndrome. The aim of this study is to identify the association of gender, marital status, age and university on knowledge, awareness and attitude of post-COVID-19 syndrome among medical students in four universities in Malaysia. Methods: A cross-sectional study was conducted from October 2021 to July 2022 at four universities in Malaysia which are Universiti Putra Malaysia (UPM), Universiti Islam Antarabangsa Malaysia (UIAM), Universiti Sains Malaysia (USM) and Universiti Sains Islam Malaysia (USIM). A self-administered questionnaire was administered to 355 respondents consisted of four sections, assessing socio-demographic data and knowledge, awareness and attitudes of post-COVID-19 syndrome. Results: 54.4% of the respondents had high knowledge, 53.8% had high awareness, and 55.21% had a high attitude towards post-COVID-19 syndrome. In this study, there is a significant association between knowledge on post-COVID-19 syndrome and the age among respondents. Knowledge and awareness, knowledge, and attitude as well as awareness and attitude on post-COVID-19 syndrome was also found to have significant association among respondents. Conclusion: The older age of the respondents have good knowledge towards post-COVID-19 syndrome

The level of knowledge, attitude and practice towards covid-19 immunisation among medical students in public medical schools in Malaysia.

COVID-19 is a highly contagious disease that caused a worldwide pandemic in 2020. Medical students are public advocates for COVID 19 vaccination to achieve herd immunity. Our objective is to ascertain the level of knowledge, attitude, and practice toward COVID-19 immunisation among medical students in Malaysia. The online study included four public universities in Peninsular Malaysia: Universiti Putra Malaysia, International Islamic University Malaysia, Universiti Sains Malaysia and Universiti Sains Islam Malaysia. Data collected include sociodemographic characteristics, history of COVID-19 infection, knowledge, attitude and practice towards COVID-19 immunisation. Analytical statistics were analysed with BM Statistical Package for the Social Science (SPSS) v27.0 using Pearson chi- square or Fisher’s exact test (significant if p < 0.05). From the total of 427 respondents, 60.2% had good knowledge whereby clinical students 67.0% have a higher proportion of good knowledge as compared to preclinical students 53.5% (p = 0.004). Respondents in the age group of 21 to 24 years old (p < 0.001) and 25 to 29 years old (p = 0.016), and Indian ethnicity (p = 0.006) were more likely to have good knowledge. Respondents registered in Malaysia’s National COVID-19 vaccination program were considered as having a positive attitude (N = 264, 61.8%). A vaccination rate of 100% was observed. In conclusion, 60.2% of medical students had good knowledge, 61.8% had a positive attitude and 100% were vaccinated in these four public medical schools in Malaysia. Sociodemographic factors (age group and Indian ethnicity) have an association with only good knowledge but none with the level of attitude and practice towards COVID-19 immunisation

Antioxidative Propolis From Stingless Bees (Heterotrigona Itama) Preserves EndotheliumDependent Aortic Relaxation of Diabetic Rats: The Role of Nitric Oxide and Cyclic Guanosine Monophosphate

Propolis from stingless bees (Heterotrigona itama) is a resinous compound that exhibits antihyperglycaemia, free radical scavenging, and cardioprotective properties. The effect of propolis on diabetic vessels has not been investigated. Thus, this research aimed to determine the effect of propolis supplementation on the level of antioxidants and its mechanism of action in the aorta of diabetic rats. Male Sprague-Dawley rats were divided into five groups (n=8/group): healthy (control), untreated diabetes (DM), metformin-treated diabetes (DM+M, 300 mg/kg/day metformin), propolis-treated diabetes (DM+P, 300 mg/kg/day propolis extract) and diabetes with combined treatment (DM+M+P, dosage as former). Oral supplementation was conducted for four weeks immediately upon successful induction of diabetes by streptozotocin (60 mg/kg, intraperitoneal injection). At the end of the study, the rats were euthanised, and thoracic aorta was processed into tissue homogenates to determine the levels of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase-1 (GPx-1) and soluble receptor for advanced glycation end-products (sRAGE). Aorta segments were harvested to examinetheir relaxation response towards graded concentration of acetylcholine (Ach; 10-8–10-4) M following precontraction with phenylephrine (PE; 10-6 M). Vasorelaxation towards a cumulative dose of propolis (0.01–1.00%) using PE-precontracted healthy aorta (n=6/experiments) was investigated under various simulated conditions: physiological buffer, L-NAME (10-4 M), methylene blue (10-5 M), indomethacin (10-5 M) and elevated glucose (25 mM). Propolis maintained antioxidative enzymes and sRAGE decoy molecules in the aortic tissue of the diabetic rats. The amelioration of diabetes-induced impairment of endothelium-dependent relaxation by propolis was mediated through the nitric oxide(NO)–cyclic guanosine monophosphate (cGMP) pathway. This non-clinical study reports vasoprotective property of propolis in diabetes mellitus

Stingless bee propolis, metformin, and their combination alleviate diabetic cardiomyopathy

Background and aim: Stingless bee propolis, a resinous compound processed by mandibular secretion of stingless bees, is used for maintenance of hygiene and stability of beehives. Research on stingless bee propolis shows therapeutic properties attributed to polyphenols exhibiting antioxidative, antihyperglycemic and antiischemic effect. However, the cardioprotective effect of stingless bee propolis on diabetic cardiomyopathy is unknown. Methods: Adult male Sprague Dawley rats were randomised to five groups: normal group, diabetic group, diabetic given metformin (DM+M), diabetic given propolis (DM+P) and diabetic given combination therapy (DM+M+P) and treated for four weeks. Body weight, fasting blood glucose, food and water intake were taken weekly. At the end of experiment, biomarkers of oxidative damage were measured in serum and heart tissue. Antioxidants in heart tissue were quantified. Part of left ventricle of heart was processed for histological staining including Haematoxylin and Eosin (H&amp;E) stain for myocyte size and Masson’s Trichrome (MT) stain for heart fibrosis and perivascular fibrosis. Results: Propolis alleviated features of diabetic cardiomyopathy such as myocyte hypertrophy, heart fibrosis and perivascular fibrosis associated with improvement in antioxidative status. Conclusion: This study reports beneficial effect of propolis and combination with metformin in alleviating histopathological feature of diabetic cardiomyopathy by modulating antioxidants, making propolis an emerging complementary therapy