7,361 research outputs found
Early childhood language memory in the speech perception of international adoptees
It is as yet unclear whether the benefits of early linguistic experiences can be maintained without at least some minimal continued exposure to the language. This study compared 12 adults adopted from Korea to the US as young children (all but one prior to age one year) to 13 participants who had no prior exposure to Korean to examine whether relearning can aid in accessing early childhood language memory. All 25 participants were recruited and tested during the second week of first-semester college Korean language classes. They completed a language background questionnaire and interview, a childhood slang task and a Korean phoneme identification task. Results revealed an advantage for adoptee participants in identifying some Korean phonemes, suggesting that some components of early childhood language memory can remain intact despite many years of disuse, and that relearning a language can help in accessing such a memory. Copyright © Cambridge University Press 2009.published_or_final_versio
Production benefits of childhood overhearing
The current study assessed whether overhearing Spanish during childhood helps later Spanish pronunciation in adulthood. Our preliminary report based on a subset of the data [Au et al., Psychol. Sci. 13, 238-243 (2002)] revealed that adults who overheard Spanish during childhood had better Spanish pronunciation, but not better morphosyntax, than adult learners of Spanish who had no childhood experience with Spanish. We now present data from the full sample with additional morphosyntax and pronunciation assessments, as well as measures to help rule out possible confounding prosodic factors such as speech rate, phrasing, and stress placement. Three groups of undergraduates were compared: 15 Spanish-English bilinguals (native Spanish speakers), 15 late learners of Spanish who overheard Spanish during childhood (childhood overhearers), 15 late learners of Spanish who had no regular experience with Spanish until middle or high school (typical late L2 learners). Results confirmed a pronunciation advantage for the childhood overhearers over the typical late L2 learners on all measures: phonetic analyses (VOT and degree of lenition), accent ratings (phoneme and story production), but no benefit in morphosyntax. Importantly, the pronunciation advantage did not seem attributable to prosodic factors. These findings illustrate the specificity of overhearers' advantage to phonological production. © 2003 Acoustical Society of America.published_or_final_versio
Regulation of Drosophila Vasa In Vivo through Paralogous Cullin-RING E3 Ligase Specificity Receptors
In Drosophila species, molecular asymmetries guiding embryonic development are established maternally. Vasa, a DEAD-box RNA helicase, accumulates in the posterior pole plasm, where it is required for embryonic germ cell specification. Maintenance of Vasa at the posterior pole requires the deubiquitinating enzyme Fat facets, which protects Vasa from degradation. Here, we found that Gustavus (Gus) and Fsn, two ubiquitin Cullin-RING E3 ligase specificity receptors, bind to the same motif on Vasa through their paralogous B30.2/SPRY domains. Both Gus and Fsn accumulate in the pole plasm in a Vasa-dependent manner. Posterior Vasa accumulation is precocious in Fsn mutant oocytes; Fsn overexpression reduces ovarian Vasa levels, and embryos from Fsn-overexpressing females form fewer primordial germ cells (PGCs); thus, Fsn destabilizes Vasa. In contrast, endogenous Gus may promote Vasa activity in the pole plasm, as gus females produce embryos with fewer PGCs, and posterior accumulation of Vas is delayed in gus mutant oocytes that also lack one copy of cullin-5. We propose that Fsn- and Gus-containing E3 ligase complexes contribute to establishing a fine-tuned steady state of Vasa ubiquitination that influences the kinetics of posterior Vasa deployment.open112626sciescopu
Sphingosine mediates FTY720-induced apoptosis in LLC-PK1 cells
FTY720, a synthetic sphingoid base analog, was examined as a new sphingosine kinase inhibitor, which converts endogenous sphingosine into its phosphate form. With 20 ??M of FTY720, sphingosine accumulated in the LLC-PK1 cells in a time- and dose-dependent manner. The FTY720 treated cells showed a high concentration of fragmented DNA, a high caspase-3 like activity and TUNEL staining cells. It was also found that the sphingosine and sphinganine level increased in a time- and dose-dependent manner within 12 h after the FTY720 treatment. The sphingosine kinase activity was reduced by FTY720 as much as other sphingosine kinase inhibitors, N, N-dimethylsphingosine (DMS), dl-threo-dihydrosphingosine (DHS). The fragmented DNA content as a result of the 20 ??M of FTY720 treatment and by 5 ??M of the exogenously added BSA-sphingosine complex indicated typical apoptosis. Under similar conditions, the accumulated sphingosine concentration in all the cells was almost identical even though the sphingosine distribution inside the cells was somewhat different. These results indicate that the FTY720 induced apoptosis is associated with the inhibition of the sphingosine kinase activity and is strongly associated with the successive accumulation of sphingosine.open172
Analysis of Slab and Slab Heater Cover in a Compact Endless Cast and Rolling Mill Process using Finite Element Methods
Compact Endless cast and rolling Mill (CEM) processes were developed and used to fabricate steel products such as steel slabs. However, the coiling furnace in this process was very expensive, so a new layout was suggested. As the coiling furnace was removed, the interval among the slab heaters had to be increased. This led to a temperature drop in the slab. The temperature distribution of the slab impacts quality, so new layout was developed. This paper presents a Finite Element Method (FEM) simulation of thermal behavior in the slab employing slab heater covers. All of the simulation results were verified by comparing them with experimental results. The slab moving distance at which the temperature was saturated during the process was determined to consider the steady-state and analyze the temperature distribution of the slab and slab heater. Those results revealed that the efficiency of heat conservation increased by more than 50% using the slab heater cover. Finally, a sensitivity analysis of the slab heater cover was conducted with respect to the cover design. The effects of insulator thickness, the gap distance between the slab and cover, and material parameters such as density, and specific heat were investigated to optimize the design of the slab heater cover to produce the best quality slab.11Ysciescopuskc
Surgical wound infection: epidemiology, pathogenesis, diagnosis and management
Surgical wound infection remains a significant problem following an operation, although surveillance for such infections remains a challenge exacerbated by early discharge and outpatient surgery. The riskof such infections isdetermined by technical problems with the operation, particularly bleeding, the amount of devitalized tissue created, and the need for drains within the wound, as well as such metabolic factors as obesity and diabetes. Perioperative antibiotic prophylaxis can decrease the incidence of such infections further, but a technically perfect operation is even more important
Towards a Context-Aware Knowledge Model for Smart Service Systems
The advancement of the Internet of things, big data, and mobile computing leads to the need for smart services that enable the context awareness and the adaptability to their changing contexts. Today, designing a smart service system is a complex task due to the lack of an adequate model support in awareness and pervasive environment. In this paper, we present a context-aware knowledge model for smart service systems that organizes the domain and context-aware knowledge into knowledge components based on the three levels of services: Services, Service system and Network of service systems. The context-aware knowledge model for smart service systems integrates all the information and knowledge related to smart services, knowledge components and context awareness that can play a key role for any framework, infrastructure, or applications deploying smart services. To demonstrate the approach, a case study about a chatbot as a smart service for customer support is presented
General Form of the Color Potential Produced by Color Charges of the Quark
Constant electric charge satisfies the continuity equation where is the current density of the electron.
However, the Yang-Mills color current density of the quark
satisfies the equation which is not a continuity
equation () which implies that a color charge
of the quark is not constant but it is time dependent where
are color indices. In this paper we derive general form of color
potential produced by color charges of the quark. We find that the general form
of the color potential produced by the color charges of the quark at rest is
given by \Phi^a(x) =A_0^a(t,{\bf x}) =\frac{q^b(t-\frac{r}{c})}{r}\[\frac{{\rm
exp}[g\int dr \frac{Q(t-\frac{r}{c})}{r}] -1}{g \int dr
\frac{Q(t-\frac{r}{c})}{r}}\]_{ab} where integration is an indefinite
integration, ~~ , ~~, ~~ is the retarded time, ~~ is the speed
of light, ~~ is the position of the quark at the retarded
time and the repeated color indices (=1,2,...8) are summed. For constant
color charge we reproduce the Coulomb-like potential
which is consistent with the Maxwell theory where
constant electric charge produces the Coulomb potential
.Comment: Final version, two more sections added, 45 pages latex, accepted for
publication in JHE
Anisotropic Terahertz Emission from Bi2Se3 Thin Films with Inclined Crystal Planes
We investigate the surface states of topological insulator (TI) Bi2Se3 thin films grown on Si nanocrystals and Al2O3 substrates by using terahertz (THz) emission spectroscopy. Compared to bulk crystalline Bi2Te2Se, film TIs exhibit distinct behaviors in the phase and amplitude of emitted THz radiation. In particular, Bi2Se3 grown on Al2O3 shows an anisotropic response with a strong modulation of the THz signal in its phase. From x-ray diffraction, we find that the crystal plane of the Bi2Se3 films is inclined with respect to the plane of the Al2O3 substrate by about 0.27 degrees. This structural anisotropy affects the dynamics of photocarriers and hence leads to the observed anisotropic response in the THz emission. Such relevance demonstrates that THz emission spectroscopy can be a sensitive tool to investigate the fine details of the surface crystallography and electrostatics of thin film TIs.1112Ysciescopu
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