Effect of homotaurine in patients with cognitive impairment: Results from an Italian observational retrospective study

Background & Aims: This observational retrospective study aimed at evaluating the effects of one-year administration of homotaurine (tramiprosate) in a sample patients presenting with symptoms of mild cognitive impairment. Methods: Patient’s demographic data and medical history are reported. Each patient performed brain imaging and neuropsychological assessment to reach the diagnosis. Each patient assumed 100 mg total dose of homotaurine/day. The evolution of the cognitive decline over time was evaluated my means of the Mini Mental State Examination (MMSE). Results: 245 patients from 28 different centres in Italy were recruited. Significant improvements from baseline expressed as mean MMSE total score were observed in patients with aMCI at months 8 and 12 (p < 0.0001), and in those with mMCI at month 4 (p < 0.05). Conclusions: Administration of homotaurine revealed beneficial effects in our sample population of MCI patients. Our results indicate clearly that homotaurine may well be considered as a potential symptomatic treatment for cognitive symptoms. Further research is however needed to clarify whether this compound could influence the progression of cognitive decline

Effect of homotaurine in patients with cognitive impairment: Results from an Italian observational retrospective study

Background & Aims: This observational retrospective study aimed at evaluating the effects of one-year administration of homotaurine (tramiprosate) in a sample patients presenting with symptoms of mild cognitive impairment. Methods: Patient’s demographic data and medical history are reported. Each patient performed brain imaging and neuropsychological assessment to reach the diagnosis. Each patient assumed 100 mg total dose of homotaurine/day. The evolution of the cognitive decline over time was evaluated my means of the Mini Mental State Examination (MMSE). Results: 245 patients from 28 different centres in Italy were recruited. Significant improvements from baseline expressed as mean MMSE total score were observed in patients with aMCI at months 8 and 12 (p < 0.0001), and in those with mMCI at month 4 (p < 0.05). Conclusions: Administration of homotaurine revealed beneficial effects in our sample population of MCI patients. Our results indicate clearly that homotaurine may well be considered as a potential symptomatic treatment for cognitive symptoms. Further research is however needed to clarify whether this compound could influence the progression of cognitive decline

Trattato di Diritto dell'Ambiente - Vol. II: I procedimenti Amministrativi per la tutela dell'ambiente - Capitolo 10: L'accertamento del danno ambientale

Il Trattato si compone di tre volumi, con i quali si d\ue0 conto in modo pressoch\ue9 completo dell'evoluzione del diritto dell'ambiente, della sua collocazione nell'ordinamento giuridico generale e delle normative di settore che ne costituiscono il corpo disciplinare. Alla luce di ci\uf2, l'approccio dei singoli contributi di ognuno dei tre volumi del Trattato vuole essere eminentemente pratico, senza tuttavia rinunciare ad una pi\uf9 generale e sistematica riflessione intorno alla problematiche che vengono affrontate. E pour cause, verrebbe da ribadire, poich\ue9 il diritto dell'ambiente intercetta s\uec problemi, ed anche bisogni ed emergenze, a carattere concreto ma svolge, altres\uec, una funzione maieutica delineando soluzioni utili ed efficaci per molti problemi, anche al di fuori (oppure oltre) i confini della materia strettamente ambientale