37 research outputs found
Spacetime and vacuum as seen from Moscow
An extended text of the talk given at the conference ``2001: A Spacetime
Odyssey'', to be published in the Proceedings of the Inaugural Conference of
the Michigan Center for Theoretical Physics, University of Michigan, Ann Arbor,
21-25 May 2001, M.J. Duff and J.T. Liu eds., World Scientific, Singapore, 2002;
and of Historical Lecture ``Vacuum as seen from Moscow'' at the CERN Summer
School, 10 August, 2001. Contents: Introduction; Pomeranchuk on vacuum; Landau
on parity, P, and combined parity, CP; Search and discovery of ; "Mirror world"; Zeldovich and cosmological term; QCD vacuum
condensates; Sakharov and baryonic asymmetry of the universe, BAU; Kirzhnits
and phase transitions; Vacuum domain walls; Monopoles, strings, instantons, and
sphalerons; False vacuum; Inflation; Brane and Bulk; Acknowledgments;
References.Comment: 17 pages, 2 figure
Adalimumab medium-term dosing strategy in moderate-to-severe hidradenitis suppurativa:integrated results from the phase III randomized placebo-controlled PIONEER trials
Scale-free static and dynamical correlations in melts of monodisperse and Flory-distributed homopolymers: A review of recent bond-fluctuation model studies
It has been assumed until very recently that all long-range correlations are
screened in three-dimensional melts of linear homopolymers on distances beyond
the correlation length characterizing the decay of the density
fluctuations. Summarizing simulation results obtained by means of a variant of
the bond-fluctuation model with finite monomer excluded volume interactions and
topology violating local and global Monte Carlo moves, we show that due to an
interplay of the chain connectivity and the incompressibility constraint, both
static and dynamical correlations arise on distances . These
correlations are scale-free and, surprisingly, do not depend explicitly on the
compressibility of the solution. Both monodisperse and (essentially)
Flory-distributed equilibrium polymers are considered.Comment: 60 pages, 49 figure
Adalimumab medium-term dosing strategy in moderate-to-severe hidradenitis suppurativa: integrated results from the phase III randomized placebo-controlled PIONEER trials
Background: Weekly adalimumab (Humira®) is approved for the treatment of hidradenitis suppurativa (HS) based on the 12-week placebo-controlled periods of the two phase III PIONEER trials. Objectives: Using PIONEER integrated trial results, we aimed to evaluate the optimal medium-term adalimumab maintenance dosing strategy for moderate-to-severe HS. Methods: Each trial had two double-blind periods; 12-week Period A and 24-week Period B. Patients randomized to adalimumab 40 mg every week (ADAew) (Period A), were rerandomized in Period B to ADAew (ADAew/ew), ADA every other week (ADAew/eow), or placebo (ADAew/pbo). Placebo-randomized patients were reassigned in Period B to ADAew (PIONEER I) or placebo (PIONEER II). The primary outcome was HS Clinical Response (HiSCR). Patients who lost response during Period B were discontinued from the study and offered an option to enter the open-label extension (OLE) to receive ADAew. Results are reported across the two study periods, and data were combined from the two study periods and the OLE. Results: For week-12 HiSCR achievers, the HiSCR week-36 rate was 48·1% (ADAew/ew) vs. 46·2% (ADAew/eow) and 32·1% (ADAew/pbo). Combining (post hoc) these patients with week-12 partial responders further differentiated outcomes in Period B (ADAew/ew 55·7% vs. ADAew/eow 40·0% and ADAew/pbo 30·1%). Period-B adverse-event rates were ADAew/ew 59·6% vs. ADAew/eow 57·4% and ADAew/pbo 65·0%. One patient (ADAew/ew) reported a serious infection. Conclusions: Weekly adalimumab treatment, effective throughout 36 weeks, was the optimal maintenance medium-term dosing regimen for this population. At least partial response after 12 weeks with continued weekly dosing had better outcomes than dose reduction or interruption. Patients who do not show at least a partial response to weekly adalimumab by week 12 are unlikely to benefit from continued therapy. No new safety risks were identified. What's already known about this topic?. Hidradenitis suppurativa (HS) is a chronic inflammatory disease, commonly misinterpreted as an infection and treated with long-term antibiotic regimens or surgical incisions. Based on the chronicity of HS and the lack of evidence for efficacious and safe long-term HS treatments, it is important to evaluate medium- to long-term therapies for HS. Weekly adalimumab (Humira®) is approved for the treatment of moderate-to-severe HS based on the two phase III PIONEER trials. What does this study add?. This study pooled data from the two PIONEER trials, providing a more robust assessment of outcomes. After at least partial treatment success with weekly adalimumab short-term therapy (12 weeks), continuing weekly dosing during the subsequent 24 weeks had better outcomes than dose reduction or treatment interruption. Patients who do not show at least a partial response to weekly adalimumab by week 12 are unlikely to benefit from continued therapy
Desempenho dos diferentes modelos institucionais de prestação dos serviços públicos de abastecimento de água: uma avaliação comparativa no conjunto dos municípios brasileiros
Two-Loop O(alpha_s G_F M_Q^2) Heavy-Quark Corrections to the Interactions between Higgs and Intermediate Bosons
By means of a low-energy theorem, we analyze at O(alpha_s G_F M_Q^2) the
shifts in the Standard-Model W^+W^-H and ZZH couplings induced by virtual
high-mass quarks, Q, with M_Q >> M_Z, M_H, which includes the top quark.
Invoking the improved Born approximation, we then find the corresponding
corrections to various four- and five-point Higgs-boson production and decay
processes which involve the W^+W^-H and ZZH vertices with one or both of the
gauge bosons being connected to light-fermion currents, respectively. This
includes e^+e^- -> f anti-f H via Higgs-strahlung, via W^+W^- fusion (with f =
nu_e), and via ZZ fusion (with f = e), as well as H -> 2V -> 4f (with V = W,
Z).Comment: 20 pages (Latex); Physical Review D (to appear