42 research outputs found
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)
- Author
- A. -G. Wu
- A. C. Ma
- A. K. Au
- Abdel-Aziz A. K.
- Abdelfatah S.
- Abdellatif M.
- Abdoli A.
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- Abeliovich H.
- Abildgaard M. H.
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- Aflaki E.
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- Zuryn S.
- Zwerschke W.
- Publication venue
- 'Informa UK Limited'
- Publication date
- 01/01/2021
- Field of study
Get PDF7th Drug hypersensitivity meeting: part two
- Author
- Abuzgaia A.M.
- Acar E.A.
- Aguiar R.
- Aihara M.
- Aktas A.
- Al-Attar Z.
- Albert F.
- Alfirevic A.
- Alhaidari M.
- Alhilali K.
- Alonso A.B.
- Alvarez A.
- Alzahrani A.
- Amaral L.
- Andreu I.
- Antipkin Y.
- Aouam K.
- Aoyama Y.
- Aranda C.
- Ardeniz F.Ö.
- Ardern-Jones M.R.
- Ariza A.
- Arreola A.M.
- Arribas F.
- Aumiler M.R.
- Ausperger K.M.
- Azoury M.E.
- Azukizawa H.
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- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2016
- Field of study
Get PDFNo abstract availabl
The genetic architecture of the human cerebral cortex
- Author
- Adams Hieab H H
- Adams Hieab H H
- Agartz Ingrid
- Ahlijanian Michael
- Ahmad Shahzad
- Ainscough Susan
- Aisen Paul
- Albers Colleen S
- Albert Marilyn
- Alhusaini Saud
- Allard Joanne
- Almeida Marcio A A
- Alnæs Dag
- Alvim Marina K M
- Ames David
- Ames David
- Amin Najaf
- Amlien Inge K
- Amouyel Philippe
- Ances Beau
- Anderson Karen
- Anderson Tim J
- Andersson Micael
- Andreassen Ole A
- Andreassen Ole A
- Apostolova Liana
- Ard Tyler
- Arias-Vasquez Alejandro
- Armstrong Nicola J
- Armstrong Nicola J
- Arnedo Vanessa
- Arnold Steven E
- Artiges Eric
- Artiges Eric
- Ashley-Koch Allison
- Assaly Michele
- Assareh Amelia A
- Asthana Sanjay
- Atkins Joshua R
- Aydin Semiha
- Ayesa-Arriola Rosa
- Baca Marne
- Bachman David
- Banaschewski Tobias
- Barbot Alexis
- Barker Gareth
- Barone Paolo
- Bartha Rob
- Bartzokis George
- Bastin Mark E
- Bastin Mark E
- Bates Vernice
- Baune Bernhard T
- Becerra Mauricio
- Becker Andreas
- Becker James T
- Beckett Laurel
- Beckham Jean C
- Beiser Alexa S
- Belden Christine M
- Belger Aysenil
- Bell Karen L
- Berg Daniela
- Bergman Howard
- Bernard Manon
- Bernard Manon
- Bernick Charles
- Bernstein Matthew
- Beyer Frauke
- Bezivin-Frere Pauline
- Biondo Francesca
- Bis Joshua C
- Bis Joshua C
- Bishop Courtney
- Black Sandra
- Blangero John
- Blank Karen
- Bodge Courtney
- Bokde Arun
- Bonakdarpour Borna
- Boomsma Dorret I
- Borges-Neto Salvador
- Borowski Bret
- Borrie Michael
- Bralten Janita
- Brand Connie
- Brandabur Melanie
- Brandt Christine L
- Brewer James
- Brockington John
- Brodaty Henry
- Brodaty Henry
- Bromberg Uli
- Brooks David
- Brooks William M
- Brosch Jared R
- Brouwer Rachel M
- Brown Gregory G
- Bruehl Ruediger
- Brunner Han G
- Buckholtz Neil
- Buckner Randy L
- Budson Andrew E
- Buimer Elizabeth E L
- Buitelaar Jan K
- Burke Anna
- Burns Jeffrey M
- Bustillo Juan R
- Bülow Robin
- Bülow Robin
- Bürger Christian
- Bÿchel Christian
- Cabrera Yuliana
- Cahn Wiepke
- Cairns Murray J
- Cairns Nigel J
- Calhoun Vince
- Cannon Dara M
- Capote Horacio
- Carlsson Cynthia M
- Carmichael Owen
- Carr Vaughan J
- Carrillo Maria
- Carroll Maria
- Carson Richard E
- Carter Raina
- Casaceli Cynthia
- Casalin Paola
- Caseras Xavier
- Caspell Chelsea
- Caspers Svenja
- Catafau Ana
- Cavalleri Gianpiero L
- Cedarbaum Jesse
- Cellar Janet S
- Celmins Dzintra
- Cendes Fernando
- Chahine Lama
- Chakravarty Mallar
- Chalker Alison
- Chao Steven
- Chen Kewei
- Chen Qiang
- Chertkow Howard
- Cheung Joshua W
- Chiang Gloria
- Ching Christopher R K
- Chowdhury Munir
- Chowdhury Sohini
- Chu Congying
- Cichon Sven
- Clark Christopher M
- Clark David
- Coffey Christopher
- Coleman Edward
- Colodro-Conde Lucía
- Comery Thomas
- Conrad Gary
- Conrod Patricia
- Consortium CHARGE
- Consortium Enhancing NeuroImaging Genetics through Meta-Analysis
- Consortium EPIGEN
- Consortium IMAGEN
- Consortium SYS
- Correia Stephen
- Corvin Aiden
- Couvy-Duchesne Baptiste
- Crawford Karen
- Creech Mary L
- Crespo-Facorro Benedicto
- Crivello Fabrice
- Curran Joanne E
- D'Agostino Daniel
- Daedelow Laura
- Daiello Lori A
- Dale Anders M
- Dale Anders M
- Dalley Jeffrey
- Dalrymple-Alford John C
- Dalvie Shareefa
- Dang Mimi
- Dannlowski Udo
- Darin Abigail
- Davies Gareth E
- Davies Peter
- de Araujo Tânia K
- de Geus Eco J C
- de Zubicaray Greig I
- de Zwarte Sonja M C
- Deary Ian J
- Deary Ian J
- Debette Stephanie
- Debette Stephanie
- Decarli Charles
- DeCarli Charles
- Deeley Cheryl
- Degenhardt Franziska
- Delanty Norman
- DeMarco Kathryn
- den Braber Anouk
- Dennis Michelle F
- Depondt Chantal
- Desrivieres Sylvane
- Desrivières Sylvane
- Dietsche Bruno
- Djurovic Srdjan
- Doan Nhat Trung
- Doherty Colin P
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- Dolen Sara
- Donohoe Gary
- Donohue Michael
- Doody Rachelle S
- Dooley Eoin
- Doraiswamy P Murali
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- Duara Ranjan
- Dubow Jordan S
- Dunlop Becky
- Egebjerg Jan
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- El Khouli Riham
- Engelbrecht Hannah-Ruth
- Erk Susanne
- Espay Alberto
- Espay Kristy
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- Faber Kelley
- Factor Stewart
- Fan Chun Chieh
- Fargher Kristin
- Farlow Martin R
- Fatica Parianne
- Fedko Iryna O
- Feldman Howard
- Fernandez Hubert
- Fernández Guillén
- Figurski Michal
- Filippi Irina
- Fillit Howard
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- Finger Elizabeth
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- Flashman Laura A
- Fleisher Adam
- Fletcher Evan
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- Flor Herta
- Foley Sonya F
- Fontaine Deborah
- Fontoura Paulo
- Ford Judith M
- Fornage Myriam
- Fornage Myriam
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- Foroud Tatiana M
- Forstner Andreas J
- Foster Eric
- Foster Norm
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- Francks Clyde
- Frank Richard
- Frank Samuel
- Franke Barbara
- Franklin Erin
- Franz Carol E
- Frasier Mark
- Frouin Vincent
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- Gigliotti Christina
- Gil Yolanda
- Gillespie Nathan A
- Glahn David C
- Gloer Katherine
- Goldman Aaron L
- Goldstein Bonnie S
- Goldstein David B
- Gollub Randy L
- Gowland Penny
- Gowland Penny A
- Grabe Hans J
- Grabe Hans Jörgen
- Grachev Igor D
- Graff-Radford Neill R
- Grasby Katrina L
- Green Davis Robert C
- Green Melissa J
- Green Robert C
- Green Robert C
- Greig-Custo Maria T
- Griffith Randall
- Grimmer Yvonne
- Groenewold Nynke A
- Grossman Hillel
- Grotegerd Dominik
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- Gunter Jeff
- Gurholt Tiril P
- Guthrie Stephanie
- Gutman Boris A
- Hake Ann Marie
- Hansell Narelle K
- Hardy Peter
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- Harlan Sherry
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- Harris Mathew A
- Harrison Marc B
- Hart David
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- Harvey Danielle
- Hashimoto Ryota
- Haswell Courtney C
- Hauser Michael
- Hauser Robert
- Hawkins Keith A
- Hefti Franz
- Heidebrink Judith L
- Heindel Walter
- Heinz Andreas
- Heinz Andreas
- Heinzen Erin L
- Henskens Frans A
- Hergesheimer Lindsey
- Herms Stefan
- Hernando Raymundo
- Herring Scott
- Heslenfeld Dirk J
- Hetelle Joel
- Hewitt David L
- Heyn Chris Chinthaka
- Hibar Derrek P
- Hillegers Manon H J
- Himali Jayandra J
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- Hofman Albert
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- Holtzman David
- Homuth Georg
- Hong L Elliot
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- Hu Shu-Ching
- Hulshoff Pol Hilleke E
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- Häusler Alexander N
- Håberg Asta K
- Ihlenfeld Albrecht
- Ikeda Masashi
- Ikram M Arfan
- Ikram M Arfan
- Ing Alex
- Initiative Alzheimer’s Disease Neuroimaging
- Initiative Parkinson’s Progression Markers
- Iranzo Alex
- Isaacson Stuart
- Isensee Corinna
- Ismail M Saleem
- Ittermann Bernd
- Jack Clifford R
- Jack Clifford R
- Jagust William
- Jahanshad Neda
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- Janowitz Deborah
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- Johnson Sterling
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- Karama Sherif
- Karlawish Jason H
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- Klein Marieke
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- Knodt Annchen R
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- Knopman David
- Kochunov Peter
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- Krämer Bernd
- Kuller Lew
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- Kwok John B J
- Lah James J
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- Logue Mark
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- Longstreth William T
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- Loughland Carmel M
- Love Marissa Natelson
- Lu Po H
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- Maingault Sophie
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- Marshall Gad A
- Marson Daniel
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- Martinot Jean-Luc
- Martinot Jean-Luc
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- Mathalon Daniel H
- Mather Karen A
- Mather Karen A
- Mathews Dana
- Mathias Samuel R
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- Matthews Brandy R
- Matthews Sarah
- Mayoral Van Son Jaqueline
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- McMahon Katie L
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- Medland Sarah E
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- Mendick Susan
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- Meyer-Lindenberg Andreas
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- Paillere Marie-Laure
- Painter Jodie N
- Panizzon Matthew S
- Pantelis Christos
- Papadopoulos Dimitri
- Parfitt Francine
- Pasternak Stephen
- Paul Steven
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- Paus Tomáš
- Pausova Zdenka
- Pausova Zdenka
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- Pavlosky William
- Pawluczyk Sonia
- Pearlson Godfrey D
- Pearson John F
- Penninx Brenda W J H
- Pentilla Jani
- Perron Michel
- Perry David
- Petersen Ronald
- Petrella Jeffrey R
- Pierce Aimee
- Pike G Bruce
- Pike G Bruce
- Pirpamer Lukas
- Pitcher Toni L
- Pizzagalli Fabrizio
- Poewe Werner
- Poki-Walker Kim
- Polderman Tinca J C
- Poline Jean-Baptiste
- Pomara Nunzio
- Porsteinsson Anton P
- Portillo Alicia
- Posthuma Danielle
- Potkin Steven
- Potter William
- Poustka Luise
- Preda Adrian
- Psaty Bruce M
- Pütz Benno
- Quiceno Mary
- Quidé Yann
- Quinlan Erin B
- Quinlan Erin Burke
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- Ragothaman Anjanibhargavi
- Raichle Marc
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- Rashid Faisal M
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- Reinbold Céline S
- Reith Alastair D
- Relkin Norman
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- Rietschel Marcella
- Riordan Cheryl
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- Robbins Trevor
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- Rocha Cristiane S
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- Shibley Victoria
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- Shim Hyungsub
- Shin Jean
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- Singleton-Garvin Jamika
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- Thompson Paul
- Thompson Paul M
- Tingus Kathleen
- Tinklenberg Jared
- Todd Gretchen
- Toga Arthur
- Toga Arthur W
- Toga Arthur W
- Tolosa Eduardo
- Tooney Paul A
- Tordesillas-Gutiérrez Diana
- Torres Fábio R
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- Tremont Geoffrey
- Trncic Nadira
- Trojanowki John Q
- Trollor Julian
- Trollor Julian N
- Turner Jessica A
- Turner Raymond Scott
- Tzourio Christophe
- Uhlmann Anne
- Uitterlinden André G
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- Umek Robert
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- van der Brug Marcel
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- Van der Wee Nic J A
- van Donkelaar Marjolein M J
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- van Dyck Christopher H
- van Eijk Liza
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- van Noort Betteke
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- Vernooij Meike W
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- Völker Uwe
- Völzke Henry
- Walter Henrik
- Walter Henrik
- Walter Sarah
- Walton Esther
- Wang Mingyuan
- Wang Yunpeng
- Ward Chad
- Wardlaw Joanna M
- Wardlaw Joanna M
- Weber Bernd
- Weinberger Daniel R
- Weiner Michael
- Weiner Michael W
- Weintraub Sandra
- Wen Wei
- Wen Wei
- Westlye Lars T
- Whelan Christopher D
- Whelan Robert
- Whelan Robert
- White Tonya
- Willeke Diana
- Williams Karen
- Williams Steve
- Wilson Renee
- Winkfield David
- Witbracht Megan
- Witt Stephanie H
- Witte A Veronica
- Wittfeld Katharina
- Wittfeld Katharina
- Wolf Christiane
- Wolfers Thomas
- Wolk David A
- Womack Kyle
- Wong Terence Z
- Woo Ellen
- Wright Margaret J
- Wright Margaret J
- Wu Chuang-Kuo
- Wu Jing Qin
- Wurster Isabel
- Xia Rui
- Yamamori Hidenaga
- Yanez Beatriz
- Yang Mia
- Yang Qiong
- Yang Qiong
- Yankey Jon
- Yasuda Clarissa L
- Yeh Randy
- Yesavage Jerome
- Zamrini Edward
- Zare Habil
- Zaremba Dario
- Zhang Zuo
- Zhou Juan
- Zhu Alyssa H
- Zimmerman Earl A
- Ziolkowski Jaimie
- Zsembik Leo C P
- Zwiers Marcel P
- Publication venue
- 'American Association for the Advancement of Science (AAAS)'
- Publication date
- 01/01/2020
- Field of study
Get PDFThe cerebral cortex underlies our complex cognitive capabilities, yet little is known about the specific genetic loci that influence human cortical structure. To identify genetic variants that affect cortical structure, we conducted a genome-wide association meta-analysis of brain magnetic resonance imaging data from 51,665 individuals. We analyzed the surface area and average thickness of the whole cortex and 34 regions with known functional specializations. We identified 199 significant loci and found significant enrichment for loci influencing total surface area within regulatory elements that are active during prenatal cortical development, supporting the radial unit hypothesis. Loci that affect regional surface area cluster near genes in Wnt signaling pathways, which influence progenitor expansion and areal identity. Variation in cortical structure is genetically correlated with cognitive function, Parkinson's disease, insomnia, depression, neuroticism, and attention deficit hyperactivity disorder
Effect of angiotensin-converting enzyme inhibitor and angiotensin receptor blocker initiation on organ support-free days in patients hospitalized with COVID-19
- Author
- ?ivko Iris
- Abbass Hakam
- Abdeladim Lilia
- Abdelhady Hesham
- Abdelkharim Hussam
- Abdelrazik Marwa
- Abdi Zakee
- Abdukahil Sheryl Ann
- Abel Lynn
- Abraham Jacinta
- Abrahamson Gail
- Abusamra Yousuf
- Aceto Romina
- Adams Nick
- Adams Peter
- Adebambo Olumide
- Adhikari Neill
- Adhikari Sheetal
- Affleck Julia
- Agha Gloria
- Aghemo Alessio
- Agno Ronan
- Ahmad Norfaizan
- Ain Quratul
- Ainscough Kate
- Ainsworth James
- Aitken Lindianne
- Akamp Ceren
- Al Enezi Farhan
- Al-Bassam Wisam
- Al-Beidh Farah
- Albert Martin
- Albrett Jonathan
- Alderman Meera
- Aldo Bonizzoni Matteo
- Alegria Ana
- Alessandro Carà Gianmarco
- Alexander Brian
- Alexander Peter
- Alfonso Jordan
- Ali Maryam
- Ali Murtaza
- Allam Hayat
- Allen Barbara
- Allen Louise
- Allibone Suzanne
- Almeshhedani Hasham
- AlQahtani Samah
- Alswaidan Lolowa
- Altomy Mohammed
- Al Amri Ali
- Al Qasim Eman
- Amatya Sameena
- Ambrosino Richard
- Anderson Thomas
- Andreae Mark
- Aneman Anders
- Angus Derek C.
- Anjum Aisha
- Ankert Juliane
- Annane Djillali
- Anne-Laure Fedou
- Anstey Matthew
- Antcliffe David
- Anthony Alpha
- Antoine Marchalot
- Antoine Pierre
- Antoine Studer
- Anumakonda Vikram
- Aparicio Christelle
- Aquino Maia
- Arabi Yaseen M.
- Arachchige Malka
- Aravindan Latha
- Arbane Gill
- Archambault Patrick
- Archer Simon
- Aref Noah
- Arias Ana-Marie
- Arias Sonia
- Arishi Hatim
- Arnold Donald
- Arnold John
- Arnott Andrew
- Arora Anand
- Aryal Diptesh
- Asghar Adeeba
- Asif Namra
- Aspinwall Angelique
- Attokaran Antony
- Attwood Ben
- Au Carly
- Audry Mathilde
- Austin Karen
- Austin Pauline
- Auvet Adrien
- Avard Bronwyn
- Awan Sidra
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- Barbash Ian
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- Barreau Amelie
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- Paramasivam Elankumaran
- Parekh Dhruv
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- Parke Rachael L.
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- Ralston Maximillian
- Ramakrishnan N
- Ramali Mohamed
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- Stratton Emma
- Stronach Lucy
- Suber Tomeka
- Sukuraman Anila
- Summerfield Anna
- Summers Charlotte
- Sundaram Radha
- Sundaran Dhinesh
- Sunkara Krishna
- Surti Zuhra
- Sutherland Helen
- Sutherland Sara-Beth
- Sutterlin Laetitia
- Sutton Joanne
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- Sven?ek Franc
- Svit?kar Nikolai
- Swabe Jacqueline
- Sweet Katie
- Sy Eric
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- Szawarski Piotr
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- Tait Jennifer
- Talia Nadine
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- Tamme Kadri
- Taqdees Huda
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- Tate Margaret
- Tatham Kate
- Tavares Silvia
- Taylor Holly
- Taylor Melanie
- Taylor Sian
- Tee Ameila
- Templeton Maie
- Teo Hoon
- Terrill Lenae
- The Stephanie
- Thedinga Karen
- Thomas Amy
- Thomas Ashly
- Thomas Emma
- Thomas Helen
- Thomas Matt
- Thomas Vicky
- Thompson Patricia
- Thompson Taylor
- Thomson Nicola
- Thrush Jessica
- Thurairatnam Saranya
- Tierney Carey
- Tinmouth Alan
- Tirot Patrice
- Tlayjeh Haytham
- Toffalo Sue
- Tolppa Timo
- Tomasi Enrico
- Tomlinson Helen
- Tong Steve
- Tong Steven
- Tony Kiran
- Totzke Juliane
- Touma Omar
- Towns Miriam
- Trapani Tony
- Trask Kara
- Traverse Eleanor
- Trickey Jemma
- Trim Fiona
- Trimmer Ken
- Triulzi Darrell
- Troeman Darren
- Trues Estefania
- Truman Nicholas
- Tsakiridou Kyriaki
- Tsang Jennifer
- Tsinaslanidis Georgios
- Tuckwell Caroline
- Tully Redmond
- Tully Riona
- Tung Raymond
- Tupper-Carey Daryl
- Turgeon Alexis F.
- Turki Salah
- Turner Anne M.
- Turner Elizabeth
- Turner Keri
- Turner-Bone Ian
- Turns Margaret
- TV Bharath
- Udayanga Ishara
- Uddin Ruzena
- Udy Andrew
- Ullmann Hannah
- Umrani Zulfiqar
- Unsworth Adam
- Uriel Alison
- Ustianowski Andrew
- Uyeki Tim
- Vaara Suvi
- Vaduganathan Muthiah
- Vahtera Annukka
- Vale Cassandra
- Valentine Eliza
- Vamplew Luke
- van Amerongen Roosmarijn
- van Bentum-Puijk Wilma
- van Bree Sjoerd
- van de Veerdonk Frank L.
- van den Berg Lettie
- van den Oever Huub
- van der Eng Hetty
- Van Der Heyden Kymbalee
- van der Kraan-Donker Annemarie
- van Gulik Laura
- van Haren Frank
- Van Hecke Jolien
- van Kimmenade Roland
- van Nieuwkoop Kees
- van Zanten Arthur
- van Zuylen Tamara
- Van?t Hoff William
- Vandewoestyne Sophie
- Vanjak Christian
- Vanmali Piyush
- van Opdorp Marjolein
- van Vonderen Marit
- Vargas Jr. Jesus
- Varghese Siby
- Vautier Sarah
- Vazquez-Grande Gloria
- Veenith Tonny
- Veillard Marion
- Venkatesh Bala
- Verlander Mark
- Vermassen Joris
- Vermeiren Daisy
- Vermont - van der Staaij Janine
- Verrier Nathalie
- Vertue Mark
- Verula Jerik
- Victor Saji
- Viehman Alex
- Vieillard-Baron Antoine
- Vignesh C
- Villot Solenne
- Vilá Clara
- Vincent Rachel
- Virdee Satwinder
- Visentin Elisa
- Visser Yorik
- Vita Tina
- Vivier Dominique
- Vodovar Dominique
- Voicu Sebastian
- Voigt Ingo
- Voiriot Guillaume
- Volkov Lev
- Voza Gennaro
- Vuylsteke Alain
- Wada Asako
- Waddington Natalia
- Wahl Nadine
- Waite Alicia
- Walden Andrew
- Walker Gena
- Walker Rachel
- Walker Susan
- Walsh Joanne
- Walsh Tim
- Walsham James
- Walton Catherine
- Wang Shu
- Ward Geraldine
- Ward Kathryn
- Ward Luke
- Warnapura Loku
- Warnock Majella
- Watchorn Olivia
- Waters Abby
- Waterson Sharon
- Watkins Claire
- Watpool Irene
- Watters Malcolm
- Watts Angela
- Waugh Victoria
- Webb Steve A.
- Weber Lisa
- Webster Denise
- Weerasinghe Thanuja
- Weismann Dirk
- Weiss Daniel
- Weissman Alexandra
- Wells Alan
- Wells Colin
- Wells Karen
- Welters Ingeborg
- West Lauren
- Westlake Samantha
- Wetherill Bill
- Wetzold Richard
- Whileman Amanda
- Whitbread Jennifer
- White Alison
- White Hayden
- White Ian
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- Whitehead Christina
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- Wibrow Bradley
- Wigbers Jeanette
- Wijewardena Gayathri
- Wilby Elizabeth
- Wilcox Elizabeth
- Wilcox Louise
- Wild Helen
- Wild Laura
- Wilding Laura
- Wiles Matt
- Wiley Daisy
- Wilhelmsen Elva
- Wilkinson Dean
- Willams Felicity
- Williams Alexandra
- Williams Angharad
- Williams Anna
- Williams Erin
- Williams Gemma
- Williams Hannah
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- Williams Marie
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- Williams Penny
- Williams Tony
- Williams Virginie
- Williamson Dawn
- Williamson James D
- Willis Joanna
- Willson Jayne
- Wilson Anna
- Wilson Craig
- Wilson Jean
- Wilson Maggie
- Winters James
- Winters Lauren
- Wise Matt
- Wisniewski Mary
- Wittekamp Bastiaan
- Wittenberg Wendy
- Wnuk Chris
- Woelke Amy
- Wong Jenny
- Wong Onyee
- Wood Erica
- Wood Hannah
- Wood Tracy
- Woods Jane
- Woods Lindsey
- Woodward Robert
- Woolett Melissa
- Worner Ruth
- Wren Jess
- Wren Lynn
- Wrey Brown Caroline
- Wright Chris
- Wright Kim
- Wunderley Renee
- Wyatt Rachel
- Wylie Katharine
- Xavier Kugan
- Yamagishi Yoshiaki
- Yamashita Chizuru
- Yang Yang
- Yarad Elizabeth
- Yates Bryan
- Yates David
- Yealy Donald
- Young Ian
- Young Meredith
- Young Paul
- Youngstein Taryn
- Yu Haili
- Yusuff Hakeem
- Zaharia Mihaela
- Zaidi Abbas
- Zaki Ahmed
- Zaman Mohsin
- Zarychanski Ryan
- Zdanavidiene Ausra
- Zhao Xiao
- Zinzoni Vanessa
- Zitter Letizia
- Zouita Louisa
- Publication venue
- 'American Medical Association (AMA)'
- Publication date
- 11/04/2023
- Field of study
Get PDFIMPORTANCE Overactivation of the renin-angiotensin system (RAS) may contribute to poor clinical outcomes in patients with COVID-19.
Objective To determine whether angiotensin-converting enzyme (ACE) inhibitor or angiotensin receptor blocker (ARB) initiation improves outcomes in patients hospitalized for COVID-19.
DESIGN, SETTING, AND PARTICIPANTS In an ongoing, adaptive platform randomized clinical trial, 721 critically ill and 58 non–critically ill hospitalized adults were randomized to receive an RAS inhibitor or control between March 16, 2021, and February 25, 2022, at 69 sites in 7 countries (final follow-up on June 1, 2022).
INTERVENTIONS Patients were randomized to receive open-label initiation of an ACE inhibitor (n = 257), ARB (n = 248), ARB in combination with DMX-200 (a chemokine receptor-2 inhibitor; n = 10), or no RAS inhibitor (control; n = 264) for up to 10 days.
MAIN OUTCOMES AND MEASURES The primary outcome was organ support–free days, a composite of hospital survival and days alive without cardiovascular or respiratory organ support through 21 days. The primary analysis was a bayesian cumulative logistic model. Odds ratios (ORs) greater than 1 represent improved outcomes.
RESULTS On February 25, 2022, enrollment was discontinued due to safety concerns. Among 679 critically ill patients with available primary outcome data, the median age was 56 years and 239 participants (35.2%) were women. Median (IQR) organ support–free days among critically ill patients was 10 (–1 to 16) in the ACE inhibitor group (n = 231), 8 (–1 to 17) in the ARB group (n = 217), and 12 (0 to 17) in the control group (n = 231) (median adjusted odds ratios of 0.77 [95% bayesian credible interval, 0.58-1.06] for improvement for ACE inhibitor and 0.76 [95% credible interval, 0.56-1.05] for ARB compared with control). The posterior probabilities that ACE inhibitors and ARBs worsened organ support–free days compared with control were 94.9% and 95.4%, respectively. Hospital survival occurred in 166 of 231 critically ill participants (71.9%) in the ACE inhibitor group, 152 of 217 (70.0%) in the ARB group, and 182 of 231 (78.8%) in the control group (posterior probabilities that ACE inhibitor and ARB worsened hospital survival compared with control were 95.3% and 98.1%, respectively).
CONCLUSIONS AND RELEVANCE In this trial, among critically ill adults with COVID-19, initiation of an ACE inhibitor or ARB did not improve, and likely worsened, clinical outcomes.
TRIAL REGISTRATION ClinicalTrials.gov Identifier: NCT0273570
Influence of row spacing on water use and yield of rain-fed wheat (Triticum aestivum L.) in a no-till system with stubble retention
- Author
- Publication venue
- 'CSIRO Publishing'
- Publication date
- 01/01/2010
- Field of study
Full text link4. Issues in Indian Philosophy and Its History. Denkschriften der philosophisch-historischen Klasse|Expanding and Merging Horizons Denkschriften der philosophisch-historischen Klasse 351. Band|
- Author
- Bhattacharya Ramkrishna
- Biernacki Loriliai
- Bronkhorst Johannes
- Elkman (Swami Atmajnanananda) Stuart
- Fort Andrew O.
- Gerschheimer Gerdi
- Harikai Kunio
- Heesterman Jan C.
- Mejor Marek
- Mesquita Roque
- Motegi Shujun
- Nozawa Masanobu
- Oetke Claus
- O´Leary Joseph S.
- Schmithausen Lambert
- Stern Elliot M.
- Tillemans Tom
- Torella Raffaele
- Verpoorten Jean-Marie
- Wada Toshihiro
- Woo Jeson
- Yoshimizu Kiyotaka
- Publication venue
- oeaw
- Publication date
- 04/01/2008
- Field of study
Full text linkEffects of Specific Multi-Nutrient Enriched Diets on Cerebral Metabolism, Cognition and Neuropathology in AbetaPPswe-PS1dE9 Mice
- Author
- A Basu
- A Dedeoglu
- A Depino
- A Fujii
- A Garthe
- A Hamilton
- A Leaf
- A Pfefferbaum
- A Solomon
- AD Dangour
- AL Guerrero
- AM Enciu
- Amanda J. Kiliaan
- Anne Rijpma
- Arend Heerschap
- BD Frederick
- BM van Gelder
- C Eriksson
- C Iadecola
- C Janus
- C Song
- C Song
- CA von Arnim
- CC Chiu
- CJ Lavie
- CP Figueiredo
- CR Hooijmans
- CV Vorhees
- D Jansen
- D Lutjohann
- D Lutjohann
- D Van Dam
- Diane Jansen
- Dieter Lütjohann
- DJ Meyerhoff
- DL Brody
- DM Juric
- E Bonnet
- E Braak
- E Kawakita
- EP Kennedy
- F Francis
- F Streijger
- FM Sacks
- G Barcelo-Coblijn
- G Chen
- G Fontani
- GA Higgins
- GT Grossberg
- GW Arendash
- HR Griffith
- HS Bhatia
- I Bjorkhem
- I Carrie
- I Fedorova
- I Skoog
- Ilse A. C. Arnoldussen
- IY Choi
- J Goodfellow
- J Oberg
- J Puolivali
- JA Joseph
- JC de la Torre
- JG Gleeson
- JH Lee
- JJ Locascio
- JL Jankowsky
- JL Jankowsky
- JL Mason
- JM Bourre
- JM Geleijnse
- JM Vela
- JP de Bruin
- JR Moffett
- K Boekhoorn
- K Kantarci
- K Kantarci
- K Kitajka
- K Naliwaiko
- K Welsh
- K Yaffe
- K Yamada
- Ken Arai
- KM Thelen
- KN Green
- L Ferretti
- L Ginsberg
- L Lauritzen
- L Lovasic
- L Teri
- L Wu
- LA Horrocks
- LA Teather
- Laus M. Broersen
- Leo A. B. Joosten
- LM Broersen
- M Demars
- M Heverin
- M Heverin
- M Marjanska
- M Oksman
- M Rusanen
- M von Kienlin
- Malgorzata Miller
- Martina P. C. Mutsaers
- Maximilian Wiesmann
- MC Morris
- MG Proescholdt
- MP Mattson
- N Ackl
- N Farina
- N Okuda
- N Schuff
- N Taniuchi
- NM De Bruin
- O Lazarov
- O Lazarov
- O van de Rest
- P Barberger-Gateau
- P Scheltens
- P Schipper
- P Simon
- PC Calder
- PG Reeves
- Pieter J. Dederen
- PJ Kamphuis
- PJ Rogers
- PJ Savelkoul
- PJ Strijbos
- PL Pugh
- R Cuppini
- R Lalonde
- R Lalonde
- R Lalonde
- R Morris
- R Shrivastava
- RA Whitmer
- RE Mrak
- RE Tanzi
- RJ Wurtman
- RJ Wurtman
- RJ Wurtman
- RS Doody
- S Cavassila
- S Holguin
- S Holguin
- S Kalmijn
- S Kotani
- S MacKay
- SB Matousek
- SC Dyall
- SE Rose
- SQ Chen
- SQ Chen
- SS Shaftel
- SS Shaftel
- SS Shaftel
- T Farkas
- T Kavanagh
- T Niidome
- T Takeuchi
- T Watanabe
- TD Schmittgen
- TP O′Leary
- UN Das
- V Conte
- V Govindaraju
- V Mlynarik
- Valerio Zerbi
- W Block
- W Huang
- W Xu
- WS Harris
- WS Harris
- X Zhang
- Xiaotian T. Fang
- Y Freund-Levi
- Y Freund-Levi
- Y Tanabe
- Publication venue
- 'Public Library of Science (PLoS)'
- Publication date
- 01/01/2013
- Field of study
Get PDFContains fulltext :
119269.pdf (publisher's version ) (Open Access)Recent studies have focused on the use of multi-nutrient dietary interventions in search of alternatives for the treatment and prevention of Alzheimer's disease (AD). In this study we investigated to which extent long-term consumption of two specific multi-nutrient diets can modulate AD-related etiopathogenic mechanisms and behavior in 11-12-month-old AbetaPPswe-PS1dE9 mice. Starting from 2 months of age, male AbetaPP-PS1 mice and wild-type littermates were fed either a control diet, the DHA+EPA+UMP (DEU) diet enriched with uridine monophosphate (UMP) and the omega-3 fatty acids docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA), or the Fortasyn(R) Connect (FC) diet enriched with the DEU diet plus phospholipids, choline, folic acid, vitamins and antioxidants. We performed behavioral testing, proton magnetic resonance spectroscopy, immunohistochemistry, biochemical analyses and quantitative real-time PCR to gain a better understanding of the potential mechanisms by which these multi-nutrient diets exert protective properties against AD. Our results show that both diets were equally effective in changing brain fatty acid and cholesterol profiles. However, the diets differentially affected AD-related pathologies and behavioral measures, suggesting that the effectiveness of specific nutrients may depend on the dietary context in which they are provided. The FC diet was more effective than the DEU diet in counteracting neurodegenerative aspects of AD and enhancing processes involved in neuronal maintenance and repair. Both diets elevated interleukin-1beta mRNA levels in AbetaPP-PS1 and wild-type mice. The FC diet additionally restored neurogenesis in AbetaPP-PS1 mice, decreased hippocampal levels of unbound choline-containing compounds in wild-type and AbetaPP-PS1 animals, suggesting diminished membrane turnover, and decreased anxiety-related behavior in the open field behavior. In conclusion, the current data indicate that specific multi-nutrient diets can influence AD-related etiopathogenic processes. Intervention with the FC diet might be of interest for several other neurodegenerative and neurological disorders
Constant Mental Change and Unknowability in Psychoanalysis
- Author
- Arlow J. A.
- Arlow J. A.
- Arlow J. A.
- Balter L.
- Balter L.
- Blum H. P.
- Brenner C.
- Brenner C.
- Brenner C.
- Brenner C.
- Fenichel O.
- Freud A.
- Freud S.
- Galatzer-Levy R.
- Gill M. M.
- Gray P.
- Hartmann H.
- Hartmann H.
- Hoffer A.
- Joseph B.
- Kohut H.
- Kohut H.
- Kohut H.
- Kohut H.
- Kris E.
- Leary K.
- Michels R.
- Mitchell S.
- Mitchell S.
- Moran M. G.
- Poland W.
- Rapaport D.
- Renik O.
- Schafer R.
- Shapiro T.
- Spencer J. H.
- Stein M. H.
- Strachey J.
- Waelder R.
- Publication venue
- 'Informa UK Limited'
- Publication date
- Field of study
Full text linkInterpersonal Behavior of Children at Risk for Schizophrenia
- Author
- Allan F. Mirsky
- American Psychiatric Association
- Baumrind D.
- Becker W. C.
- Bender L.
- Bleuler E.
- Chance E.
- Cornblatt B.
- Erlenmeyer-Kimling L.
- Fiske D. W.
- Guttman L.
- Joseph Marcus
- Judith G. Auerbach
- Kellam S. G.
- Kolb B.
- Koppitz E. M.
- Leary T.
- Lewine R. R. J.
- Lewis D. O.
- Linda Henson
- Mednick S. A.
- Porteus S. D.
- Raven J. C.
- Ricks D. F.
- Ricks D. F.
- Robins L. N.
- Rodnick E. H.
- Schaefer E. S.
- Spitzer R. L.
- Spitzer R. L.
- Sullivan H. S.
- Sydney L. Hans
- Wechsler D.
- Wiggins J. S.
- Wilkinson L.
- Publication venue
- 'Informa UK Limited'
- Publication date
- Field of study
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