New liquid crystal materials enabling revolutionary display devices

The Display and Beam Steering Thrust of the AFOSR Liquid Crystal MURI addressed key materials and device technology issues affecting performance of liquid crystal (LC) electro-optic (EO) devices, particularly device structures useful in information Displays and for Laser Beam Steering and Switching. Two basic themes were development of bulk LCs having high performance characteristics (nematic LCs, and chiral smectic LC devices having analog response), and development of novel LC electro-optic structures. Research on novel device structures led to advances in LC alignment and on photonic band-gap materials

The MAGellanic Inter-Cloud (MAGIC) project - II. Slicing up the Bridge

The origin of the gas in between the Magellanic Clouds (MCs), known as the Magellanic Bridge, has always been the subject of controversy. To shed light into this, we present the results from the MAGellanic Inter-Cloud II (MAGIC II) project aimed at probing the stellar populations in 10 large fields located perpendicular to the main ridge-line of H i in the Inter-Cloud region. We secured these observations of the stellar populations in between the MCs using the WFI (Wide Field Imager) camera on the 2.2 m telescope in La Silla. Using colour–magnitude diagrams, we trace stellar populations across the Inter-Cloud region. In good agreement with MAGIC I, we find significant intermediate-age stars in the Inter-Cloud region as well as young stars of a similar age to the last pericentre passage in between the MCs (∼200 Myr ago). We show here that the young, intermediate-age and old stars have distinct spatial distributions. The young stars correlate well with the H i gas suggesting that they were either recently stripped from the Small Magellanic Cloud (SMC) or formed in situ. The bulk of intermediate-age stars are located mainly in the Bridge region where the H i column density is higher, but they are more spread out than the young stars. They have very similar properties to stars located ∼2 kpc from the SMC centre, suggesting that they were tidally stripped from this region. Finally, the old stars extend to some 8 kpc from the SMC supporting the idea that all galaxies have a large extended metal-poor stellar halo

The MAGellanic Inter-Cloud (MAGIC) project - II. Slicing up the Bridge

The origin of the gas in between the Magellanic Clouds (MCs), known as the Magellanic Bridge, has always been the subject of controversy. To shed light into this, we present the results from the MAGellanic Inter-Cloud II (MAGIC II) project aimed at probing the stellar populations in 10 large fields located perpendicular to the main ridge-line of H i in the Inter-Cloud region. We secured these observations of the stellar populations in between the MCs using the WFI (Wide Field Imager) camera on the 2.2 m telescope in La Silla. Using colour–magnitude diagrams, we trace stellar populations across the Inter-Cloud region. In good agreement with MAGIC I, we find significant intermediate-age stars in the Inter-Cloud region as well as young stars of a similar age to the last pericentre passage in between the MCs (∼200 Myr ago). We show here that the young, intermediate-age and old stars have distinct spatial distributions. The young stars correlate well with the H i gas suggesting that they were either recently stripped from the Small Magellanic Cloud (SMC) or formed in situ. The bulk of intermediate-age stars are located mainly in the Bridge region where the H i column density is higher, but they are more spread out than the young stars. They have very similar properties to stars located ∼2 kpc from the SMC centre, suggesting that they were tidally stripped from this region. Finally, the old stars extend to some 8 kpc from the SMC supporting the idea that all galaxies have a large extended metal-poor stellar halo

Human papillomavirus infection is rare in nonmalignant tonsil tissue in the UK: implications for tonsil cancer precursor lesions

The incidence of human papillomavirus (HPV)-associated tonsil cancer is increasing but the prevalence of HPV, and of premalignant precursors, in tonsil tissue is unknown. We aimed to assess prevalence of HPV infection in nonmalignant tonsillar crypt epithelia and to histopathologically characterise positive samples. Formalin-fixed paraffin-embedded (FFPE) tonsil tissue specimens were obtained from an age- and sex-stratified random sample of patients aged 0–69 years whose paired tonsils were archived following elective tonsillectomy at hospitals throughout England and Southern Scotland from 2004 to 2008. Homogenised fresh-frozen tonsil tissue was also obtained from archive for two random subsets of males aged 25–34 and over 44. HPV status was assessed in all samples for 20 mucosal HPV types by GP5+/6+ polymerase chain reaction (PCR) enzyme immunoassay and by HPV16 type-specific PCR targeting the E6 gene. In the homogenised material, HPV status was also assessed for 44 HPV types by SPF10-PCR enzyme immunoassay. Of 4,095 randomly sampled FFPE specimens, amplifiable DNA was extracted from 3,377 (82.5%) and from 511 of 524 (97.5%) homogenised tonsils. HPV DNA was identified in 0 of 3,377 (0%, 95% CI 0–0.089%) fixed samples and 0 of 511 (0%, 95% CI 0–0.58%) homogenised samples. This suggests HPV infection may be rare in tonsil reticulated crypt epithelia. Furthermore, we found no evidence of HPV-associated premalignant neoplasia. These data suggest that if HPV-associated premalignant lesions do occur, they are likely to be rare and may have a high risk of progression to carcinoma

Clinical outcomes associated with the initial use of the Canine Unicompartmental Elbow (CUE) Arthroplasty System®

We evaluated mid- to long-term outcomes with respect to function and complications in dogs undergoing canine unicompartmental elbow (CUE) arthroplasty for treatment of medial compartment disease of the elbow. This prospective multicenter case series is the first group of clinical cases to receive CUE arthroplasty. Cases (each elbow that underwent CUE performed by a participating surgeon) were enrolled into an electronic database and prospectively followed to determine and record all associated complications, as well as functional outcomes. There were 103 cases from 18 surgeons. Final follow-up time ranged from 6 to 47 mo with a mean and median of 10 mo. Canine unicompartmental elbow was associated with 1 catastrophic (1%), 11 major (10.7%), and 28 minor (27.2%) complications. Outcomes following CUE were reported as full function in 49 cases (47.6%), acceptable function in 45 cases (43.7%), and unacceptable function in 9 cases (8.7%). We conclude that CUE arthroplasty is an appropriate consideration for treatment of medial compartment disease of the elbow in dogs

“What, in a Town of War … to Manage Private and Domestic Quarrel?”: Othello and the Tragedy of Cyprus

This essay reconsiders the significance of Cyprus as the location of Othello, arguing that awareness of the island’s capture by Ottoman forces in 1571 will have been central to the play’s early reception. This context broadens the significance of the tragedy beyond the original domestic focus of a plot borrowed by Shakespeare from an Italian novella by Cinthio–one that, significantly, plays out during a period of peace rather than war. Beginning with an analysis of the affective power of the alarm bells that ring out in the riot scene (2.3), it argues that through a combination of internal and external contextual signs, Shakespeare’s original Jacobean audiences will have become united in perspective with the people of Cyprus. The significance of the loss of Othello as the island’s most capable defender, combined with the inadequacy of Cassio as his replacement, is highlighted throughout the play. This enables the specific tragic potential of Cyprus as a location to be exploited by Shakespeare in a way that was simply unavailable to Cinthio, and that may not be automatically understood by later audiences