Prevalence of complex post-traumatic stress disorder in refugees and asylum seekers: systematic review

BACKGROUND: Refugees and asylum seekers often report having experienced numerous complex traumas. It is important to understand the prevalence of complex post-traumatic stress disorder (CPTSD), which can follow complex traumas. AIMS: This systematic review aims to summarise the available literature reporting the prevalence in refugees and asylum seekers of three operationalised definitions of CPTSD: the ICD-11 diagnostic criteria, the ICD-10 criteria (for enduring personality change after catastrophic experience) and the DSM-IV criteria (for disorders of extreme stress not otherwise specified). METHOD: Six electronic databases were searched for studies reporting the prevalence of CPTSD in adult refugee and/or asylum-seeking samples. Owing to heterogeneity between the studies, a narrative synthesis approach was used to summarise studies. Methodological quality was assessed using the Joanna Briggs Critical Appraisal Checklist for Prevalence Studies. This systematic review has been registered with PROSPERO (registration number CRD42020188422, https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=188422). RESULTS: Systematic searches identified 15 eligible studies, with 10 examining treatment-seeking samples and five using population samples. CPTSD prevalence in treatment-seeking samples was between 16 and 38%. Prevalence in population samples ranged from 2.2 to 9.3% in four studies, with the fifth reporting a much higher estimate (50.9%). CONCLUSIONS: This review highlights both the high prevalence of CPTSD in treatment samples and the lack of research aiming to establish prevalence of CPTSD in refugee and asylum-seeking populations. Understanding the prevalence of these disabling disorders has implications for policy and healthcare services for the appropriate promotion, planning and provision of suitable treatment and interventions for this highly traumatised population

Expressed emotion in the South Asian diaspora living in the UK: A qualitative study

BACKGROUND: 'Expressed Emotion (EE)' captures ways in which emotions are expressed within a family environment. Research has found that EE in families has an impact on psychiatric illness, in particular psychosis, such that it increases risk of relapse. EE was conceptualised by research conducted in the UK. Thus, behaviours defined as pathological were largely based on white samples adhering to UK norms. Cross-cultural variations have been found in EE and its relationship with clinical outcomes. A more culturally appropriate understanding of norms surrounding the EE across cultures is required. AIMS: This study aims to use a bottom-up approach to provide a culturally specific understanding of family relationships and EE across 'non-clinical' UK-based South Asian families. METHODS: Semi-structured interviews were conducted with 18 South Asian participants to explore their relationships with a significant other. Interviews were analysed using thematic analysis. RESULTS: Four main themes were generated: expression of love, setting boundaries, inter-generational differences and acceptance. CONCLUSION: The findings indicate considerable cultural variability within EE and highlight the need to interpret EE in the context of socio-cultural norms. Whilst certain domains of EE that are considered pathological in Western contexts are present in the UK-based South Asian diaspora, these are perceived as less problematic, indicative of varying cultural norms

Experiences and views of frontline healthcare workers' family members in the UK during the COVID-19 pandemic: a qualitative study

Background: The COVID-19 pandemic has had a well-documented negative impact on the mental health and wellbeing of frontline healthcare workers (HCWs). Whilst no research has to date been carried out to explore the challenges experienced by the families of HCWs, some previous research has been conducted with military families, demonstrating that family members of deployed military personnel may also be affected seriously and negatively. Objectives: This study aimed to explore the experiences, views, and mental health impact on frontline HCWs' families during the COVID-19 pandemic in the UK and what support the families of frontline HCWs may need. Method: Close family members and friends of HCWs were interviewed. Transcripts were analysed in line with the principles of reflexive thematic analysis. Results: We completed fourteen interviews with three siblings, one mother, one friend, and nine spouses of HCWs. Family members were highly motivated to support healthcare workers and felt an intense sense of pride in their work. However, they also experienced increased domestic responsibilities and emotional burden due to anxiety about their loved ones' work. The fact that sacrifices made by family members were not noticed by society, the anxiety they felt about their family's physical health, the impact of hearing about traumatic experiences, and the failure of healthcare organisations to meet the needs of the HCWs all negatively affected the family members. Conclusions: We have an ethical responsibility to attend to the experiences and needs of the families of healthcare professionals. This study emphasises the experiences and needs of family members of healthcare professionals, which have hitherto been missing from the literature. Further research is needed to hear from more parents, siblings and friends, partners in same sex relationships, as well as children of HCWs, to explore the variety of family members and supporters' experiences more fully. HIGHLIGHTS: • COVID19 has impacted families of HCWs as well as workers themselves. They have experienced more anxiety, increased practical burden, significant physical health risks and been exposed vicariously to workers' traumatic experiences. We must ensure HCW families are better supported

Antimicrobial resistance and COVID-19: Intersections and implications

Before the coronavirus 2019 (COVID-19) pandemic began, antimicrobial resistance (AMR) was among the top priorities for global public health. Already a complex challenge, AMR now needs to be addressed in a changing healthcare landscape. Here, we analyse how changes due to COVID-19 in terms of antimicrobial usage, infection prevention, and health systems affect the emergence, transmission, and burden of AMR. Increased hand hygiene, decreased international travel, and decreased elective hospital procedures may reduce AMR pathogen selection and spread in the short term. However, the opposite effects may be seen if antibiotics are more widely used as standard healthcare pathways break down. Over 6 months into the COVID-19 pandemic, the dynamics of AMR remain uncertain. We call for the AMR community to keep a global perspective while designing finely tuned surveillance and research to continue to improve our preparedness and response to these intersecting public health challenges

The Galactic dynamics revealed by the filamentary structure in atomic hydrogen emission

Funding: J.D.S., R.K.S., and S.C.O.G. are funded by the European Research Council via the ERC Synergy Grant “ECOGAL – Understanding our Galactic ecosystem: From the disk of the Milky Way to the formation sites of stars and planets” (project ID 855130). R.J.S. acknowledges funding from an STFC ERF (grant ST/N00485X/1) and HPC from the DiRAC facility (ST/P002293/1).We present a study of the filamentary structure in the atomic hydrogen (HI) emission at the 21 cm wavelength toward the Galactic plane using the observations in the HI4PI survey. Using the Hessian matrix method across radial velocity channels, we identified the filamentary structures and quantified their orientations using circular statistics. We found that the regions of the Milky Way's disk beyond 10 kpc and up to roughly 18 kpc from the Galactic center display HI filamentary structures predominantly parallel to the Galactic plane. For regions at lower Galactocentric radii, we found that the HI filaments are mostly perpendicular or do not have a preferred orientation with respect to the Galactic plane. We interpret these results as the imprint of supernova feedback in the inner Galaxy and Galactic rotation in the outer Milky Way. We found that the HI filamentary structures follow the Galactic warp and that they highlight some of the variations interpreted as the effect of the gravitational interaction with satellite galaxies. In addition, the mean scale height of the filamentary structures is lower than that sampled by the bulk of the HI emission, thus indicating that the cold and warm atomic hydrogen phases have different scale heights in the outer galaxy. Finally, we found that the fraction of the column density in HI filaments is almost constant up to approximately 18 kpc from the Galactic center. This is possibly a result of the roughly constant ratio between the cold and warm atomic hydrogen phases inferred from the HI absorption studies. Our results indicate that the HI filamentary structures provide insight into the dynamical processes shaping the Galactic disk. Their orientations record how and where the stellar energy input, the Galactic fountain process, the cosmic ray diffusion, and the gas accretion have molded the diffuse interstellar medium in the Galactic plane.Peer reviewe

The history of dynamics and stellar feedback revealed by the H i filamentary structure in the disk of the Milky Way

We present a study of the filamentary structure in the emission from the neutral atomic hydrogen (HI) at 21 cm across velocity channels in the 40′′ and 1.5-km s−1 resolution position-position-velocity cube, resulting from the combination of the single-dish and interferometric observations in The HI/OH/recombination-line survey of the inner Milky Way. Using the Hessian matrix method in combination with tools from circular statistics, we find that the majority of the filamentary structures in the HI emission are aligned with the Galactic plane. Part of this trend can be assigned to long filamentary structures that are coherent across several velocity channels. However, we also find ranges of Galactic longitude and radial velocity where the HI filamentary structures are preferentially oriented perpendicular to the Galactic plane. These are located (i) around the tangent point of the Scutum spiral arm and the terminal velocities of the Molecular Ring, around l ≈ 28◦ and vLSR ≈ 100 km s−1, (ii) toward l ≈ 45◦ and vLSR ≈ 50 km s−1, (iii) around the Riegel-Crutcher cloud, and (iv) toward the positive and negative terminal velocities. A comparison with numerical simulations indicates that the prevalence of horizontal filamentary structures is most likely the result of large-scale Galactic dynamics and that vertical structures identified in (i) and (ii) may arise from the combined effect of supernova (SN) feedback and strong magnetic fields. The vertical filamentary structures in (iv) can be related to the presence of clouds from extra-planar HI gas falling back into the Galactic plane after being expelled by SNe. Our results indicate that a systematic characterization of the emission morphology toward the Galactic plane provides an unexplored link between the observations and the dynamical behavior of the interstellar medium, from the effect of large-scale Galactic dynamics to the Galactic fountains driven by SNe.J.D.S., H.B., and Y.W. acknowledge funding from the European Research Council under the Horizon 2020 Framework Program via the ERC Consolidator Grant CSF-648505. H.B., J.S., S.C.O.G., and R.K. acknowledge support from the Deutsche Forschungsgemeinschaft via SFB 881, “The Milky Way System” (subprojects A1, B1, B2, and B8). S.C.O.G. and R.K. also acknowledge support from the Deutsche Forschungsgemeinschaft via Germany’s Excellence Strategy EXC-2181/1-390900948 (the Heidelberg STRUCTURES Cluster of Excellence). R.K. also acknowledges funding from the European Research Council via the ERC Synergy Grant ECOGAL (grant 855130) and the access to the data storage service SDS@hd and computing services bwHPC supported by the Ministry of Science, Research and the Arts Baden-Württemberg (MWK) and the German Research Foundation (DFG) through grants INST 35/1314-1 FUGG as well as INST 35/1134-1 FUGG. N.S. acknowledges support by the Agence Nationale de la Recherche (ANR) and the DFG through the project “GENESIS” (ANR-16-CE92-0035-01/DFG1591/2-1

Pandemic gardening:A narrative review, vignettes and implications for future research

There is a significant amount of evidence highlighting the health, wellbeing and social benefits of gardening during previous periods of crises. These benefits were also evident during the COVID-19 pandemic. This paper presents a narrative review exploring gardening during the early stages of the COVID-19 pandemic to understand the different forms of gardening that took place during this crisis and key elements of this activity. Research about gardening during the pandemic focused on food (in)security and disrupted food systems, the health and wellbeing benefits of gardening, and the social dimensions of gardening. We offer three vignettes of our own research to highlight key insights from local, national and international perspectives of gardening during the pandemic. The paper's conclusion outlines how researchers, policy makers and public health practitioners can harness what has been learned from gardening during the pandemic to ensure these benefits are more widely available and do not exacerbate already entrenched health inequalities in society.</p

Histogram of oriented gradients: A technique for the study of molecular cloud formation

We introduce the histogram of oriented gradients (HOG), a tool developed for machine vision that we propose as a new metric for the systematic characterization of spectral line observations of atomic and molecular gas and the study of molecular cloud formation models. In essence, the HOG technique takes as input extended spectral-line observations from two tracers and provides an estimate of their spatial correlation across velocity channels. We characterized HOG using synthetic observations of HI and 13CO (J = 1 → 0) emission from numerical simulations of magnetohydrodynamic (MHD) turbulence leading to the formation of molecular gas after the collision of two atomic clouds. We found a significant spatial correlation between the two tracers in velocity channels where vHI ≈ v13CO, almost independent of the orientation of the collision with respect to the line of sight. Subsequently, we used HOG to investigate the spatial correlation of the HI, from The HI/OH/recombination line survey of the inner Milky Way (THOR), and the 13CO (J = 1 → 0) emission from the Galactic Ring Survey (GRS), toward the portion of the Galactic plane 33°.75 ≤l ≤ 35°.25 and |b| ≤ 1°.25. We found a significant spatial correlation between the two tracers in extended portions of the studied region. Although some of the regions with high spatial correlation are associated with HI self-absorption (HISA) features, suggesting that it is produced by the cold atomic gas, the correlation is not exclusive to this kind of region. The HOG results derived for the observational data indicate significant differences between individual regions: some show spatial correlation in channels around vHI ≈ v13CO while others present spatial correlations in velocity channels separated by a few kilometers per second. We associate these velocity offsets to the effect of feedback and to the presence of physical conditions that are not included in the atomic-cloud-collision simulations, such as more general magnetic field configurations, shear, and global gas infall.s. J.D.S., H.B., M.R., Y.W., and J.C.M. acknowledge funding from the European Research Council under the Horizon 2020 Framework Program via the ERC Consolidator Grant CSF-648505. S.C.O.G. and R.K. acknowledge support from the Deutsche Forschungsgemeinschaft via SFB 881, “The Milky Way System” (subprojects B1, B2 and B8), and from the European Research Council under the European Community’s Seventh Framework Programme (FP7/2007-2013) via the ERC Advanced Grant STARLIGHT (project number 339177). F.B. acknowledges funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No. 726384. J.K. has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No. 639459 (PROMISE). S.E.R. acknowledges support from the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement No. 706390. N.R. acknowledges support from the Infosys Foundation through the Infosys Young Investigator grant. R.J.S. acknowledges support from an STFC ERF. The National Radio Astronomy Observatory is a facility of the National Science Foundation operated under cooperative agreement by Associated Universities, Inc. The Galactic Ring Survey is a joint project of Boston University and Five College Radio Astronomy Observatory, funded by the National Science Foundation. This research was carried out in part at the Jet Propulsion Laboratory, operated for NASA by the California Institute of Technology. Part of the crucial discussions that lead to this work took part under the program Milky-Way-Gaia of the PSI2 project funded by the IDEX Paris-Saclay, ANR-11-IDEX-0003-02. We thank the anonymous referee for the thorough review. We highly appreciate the comments, which significantly contributed to improving the quality of this paper. J.D.S. thanks the following people who helped with their encouragement and conversation: Peter G. Martin, MarcAntoine Miville-Deschênes, Norm Murray, Edith Falgarone, Hans-Walter Rix, Jonathan Henshaw, Shu-ichiro Inutsuka, and Eric Pellegrini

The Next 50 Years of Neuroscience

On the 50th anniversary of the Society for Neuroscience, we reflect on the remarkable progress that the field has made in understanding the nervous system, and look forward to the contributions of the next 50 years. We predict a substantial acceleration of our understanding of the nervous system that will drive the development of new therapeutic strategies to treat diseases over the course of the next five decades. We also see neuroscience at the nexus of many societal topics beyond medicine, including education, consumerism, and the justice system. In combination, advances made by basic, translational, and clinical neuroscience research in the next 50 years have great potential for lasting improvements in human health, the economy, and society.Peer reviewe