73 research outputs found
Single-Walled Carbon Nanotubes as a Molecular Heater for Thermoresponsive Polymer Gel Composite
Determination of Redox Potentials of Single-walled Carbon Nanotube by Using Spectroelectrochemistry
ナノダイナミクス国際シンポジウム 平成22年1月21日(木) 於長崎大学Nagasaki Symposium on Nano-Dynamics 2010 (NSND2010), January 21, 2010, Nagasaki University, Nagasaki, Japan, Invited Lectur
Pattern of disease progression during third-line or later chemotherapy with nivolumab associated with poor prognosis in advanced gastric cancer: a multicenter retrospective study in Japan
[Background] Accelerated tumor growth during immunotherapy in pre-existing measurable lesions, hyperprogressive disease (HPD), has been reported. However, progression of non-measurable lesions and new lesions are frequently observed in patients with advanced gastric cancer (AGC). [Methods] This retrospective study involved AGC patients at 24 Japanese institutions who had measurable lesions and received nivolumab after ≥ 2 lines of chemotherapy. HPD was defined as a ≥ two-fold increase in the tumor growth rate of measurable lesions. The pattern of disease progression was classified according to new lesions in different organs and ascites appeared/increase of ascites. [Results] Of 245 patients, 147 (60.0%) showed progressive disease (PD) as the best response and 41 (16.7%) showed HPD during nivolumab monotherapy. There was no significant difference in overall survival (OS) between patients with HPD and those with PD other than HPD (median OS 5.0 vs 4.8 months; hazard ratio [HR] 1.0, 95% confidence interval [CI] 0.6–1.5; p = 1.0). Fifty-three patients developed new lesions in different organs and 58 had appearance/increase of ascites; these patients showed shorter OS than those without each of these features (median OS 3.3 vs 7.1 months, HR 1.8, 95% CI 1.2–2.7, p = 0.0031 for new lesions, and 3.0 vs 7.8 months, HR 2.6, 95% CI 1.8–3.8, p < 0.0001 for ascites). Thirty-one patients who had both features showed the worst prognosis (median OS 2.6 months). [Conclusions] New lesions in different organs and appearance/increase of ascites, rather than the original definition of HPD, are the patterns of disease progression associated with poor prognosis in AGC patients receiving nivolumab whose best response was PD
<i>In Situ </i>Photoluminescence Spectroelectrochemistry for Determination of Electronic States of Single-Walled Carbon Nanotubes
Manipulation of cell membrane using carbon nanotube scaffold as a photoresponsive stimuli generator
Specific Molecular Interaction and Recognition at Single-Walled Carbon Nanotube Surfaces
Direct Demonstration of Attraction for a Complementary Pair of Apposed Nucleic Acid Base Monolayers
Surface Anisotropic Electroreflectance Response at an Edge-Plane Pyrolytic Graphite Electrode
Electroreflectance Study of Hemin Adsorbed on a HOPG Electrode: Estimation of Molecular Orientation and Analysis of Nonfaradaic Electroreflectance Signal Due to the Stark Effect
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