Development of Semi-Real-Time Tsunami Monitoring and Calculation System on Ocean-Bottom Stations off the Kii Peninsula, Southwest Japan

We developed a semi-real-time calculation and data monitoring system that measures pressure perturbations at ocean-bottom pressure-gauge stations deployed off the Kii peninsula in southwest Japan in order to identify tsunami signals associated with earthquakes. The system automatically calculates geodetic deformations and tsunami propagation immediately after getting seismic source information on hypocenter, magnitude, and mechanism. The calculation results for transoceanic tsunamis can be available in approximately 20 s after getting source information to output waveform data by executing the optimized parallel calculation code on our computer server SGI UV2000 with a 32-core processor unit. The system also provides tide-removed and filtered waveform data at ocean-bottom stations, enabling the calculation results to be compared with actual tsunami arrivals. System operations began in July 2015 and have been applied to tsunamigenic earthquakes in the Pacific Ocean. The system is effective in identifying tsunami signals and automatically predicting tsunami propagation in offshore areas, which may be useful for further data analyses on tsunami propagation

Efficacy, tolerability and safety of once-monthly administration of 75mg risedronate in Japanese patients with involutional osteoporosis: A comparison with a 2.5mg once-daily dosage regimen

AbstractOral risedronate has been shown to be effective in the treatment of osteoporosis when administered once-daily or once-weekly in Japan. This randomized, double-blind, multicenter 12-month study was conducted to compare the efficacy and tolerability of oral risedronate 75mg once-monthly with 2.5mg once-daily in Japanese patients with involutional osteoporosis. Bone mineral density (BMD), biochemical markers of bone metabolism, fractures, and adverse events (AEs) were evaluated. At the end of the study (Month 12, last observation carried forward [M12, LOCF]), mean percent change (SD) from baseline in lumbar spine (L2–L4) BMD, measured by dual energy X-ray absorptiometry (primary endpoint), was increased by 5.69 (4.00)% in the 2.5mg once-daily group (n=428), and 5.98 (4.54)% in the 75mg once-monthly group (n=422). In the non-inferiority t-test (non-inferiority margin Δ=1.5%), the 75mg once-monthly group was non-inferior to the 2.5mg once-daily group (p<0.0001). The difference between treatment groups was 0.28% (95% CI, −0.31% to 0.88%). Changes in biochemical markers of bone metabolism were generally comparable in the two groups, although decreases in the percent change from baseline in urinary NTX/CRN and CTX/CRN were statistically greater in the 2.5mg once-daily group than the 75mg once-monthly group. The frequency of new vertebral fractures (including aggravation of prevalent fractures) at the end of the study (M12, LOCF) was also similar in the two groups: 1.2% in the 2.5mg once-daily group and 1.3% in the 75mg once-monthly group.The incidence of mild/moderate/severe AEs was 75.5%/6.3%/0.5% in the 2.5mg once-daily group and 77.7%/8.1%/0.7% in the 75mg once-monthly group. AEs associated with gastrointestinal symptoms occurred in approximately 30% of subjects in each group but with no severe cases. AEs potentially associated with acute phase reaction (including symptoms of influenza-like illness or pyrexia starting within 3days of the first dose of the study drug and with a duration of 7days or less) only occurred in the 75mg once-monthly group (2.1%, 9/422 subjects; influenza-like symptoms in 1 subject and pyrexia in 8 subjects), although the incidence was low without any severe cases.In conclusion, risedronate 75mg once-monthly (a dosage which is 30 times higher than risedronate 2.5mg once-daily) had non-inferior efficacy in terms of BMD and was similarly well tolerated compared to the once-daily regimen in Japanese patients with involutional osteoporosis. Consistent with the once-daily and once-weekly dosage, the once-monthly dosage of risedronate 75mg was half that used outside Japan (150mg)

Longitudinal change in hip fracture incidence after starting risedronate or raloxifene: an observational study

This study examined patients' risk profiles and adherence to treatment in relation to the effect of risedronate and raloxifene on hip fracture incidence. Administrative billing data were used to follow two cohorts of women aged 65 and older after starting therapy with either risedronate (n=86,735) or raloxifene (n=37,726). The fracture risk profile was described using a 6-month history period before starting therapy. Effectiveness of each therapy was evaluated by comparing the incidence of hip fractures during the first 3months with the subsequent 12months among women adherent (medication possession ratio >80%) compared with those non-adherent to treatment. At the start of therapy, the raloxifene cohort was younger than the risedronate cohort (median age 73 vs. 76years) and had fewer prior fractures (p<0.01 for both). In the first 3months of therapy, hip fracture incidence was lower in the raloxifene group (0.51 per 100 person-years) compared with the risedronate group (0.94 per 100 person-years). In the subsequent 12months, the incidence of hip fractures decreased among patients adherent to the risedronate regimen [relative risk (RR) 0.70, 95% CI 0.59-0.84, p<0.01] and did not change significantly among patients adherent to the raloxifene regimen (RR 1.02, 95% CI 0.73-1.44). In poorly adherent patients, neither drug decreased hip fracture risk. Risedronate treatment in adherent patients rapidly decreased the risk of hip fractures, whereas raloxifene treatment did no

Deep Investigations of Outer-Rise Tsunami Characteristics Using Well-Mapped Normal Faults Along the Japan Trench

To assess the risk of tsunamis from outer-rise earthquakes, we carried out tsunami simulations using 33 simple rectangular fault models with 60° dip angles based on marine seismic observations and surveys of the Japan Trench. The largest tsunami resulting from these models, produced by a Mw 8.7 normal-faulting event on a fault 332 km long, had a maximum height of 27.0 m. We tested variations of the predictions due to the uncertainties in the assumed parameters. Because the actual dip angles of the Japan Trench outer-rise faults range from 45° to 75°, we calculated tsunamis from earthquakes on fault models with 45°, 60°, and 75° dip angles. We also tested a compound fault model with 75° dip in the upper half and 45° dip in the lower half. Rake angles were varied by ±15°. We also tested models consisting of small subfaults with dimensions of about 60 km, models using other earthquake scaling laws, models with heterogeneous slips, and models incorporating dispersive tsunami effects. Predicted tsunami heights changed by 10–15% for heterogeneous slips, up to 10% for varying dip angles, about 5–10% from considering tsunami dispersion, about 2% from varying rake angles, and about 1% from using the model with small subfaults. The use of different earthquake scaling laws changed predicted tsunami heights by about 50% on average for the 33 fault models. We emphasize that the earthquake scaling law used in tsunami predictions for outer-rise earthquakes should be chosen with great care

Neutrino induced reactions related to the ν\nu-process nucleosynthesis of 92{}^{92}Nb and 98{}^{98}Tc

It has recently been proposed that ${}^{92}_{41}$Nb and ${}^{98}_{43}$Tc may have been formed in the $\nu$-process. We investigate the neutrino induced reactions related to the $\nu$-process origin of the two odd-odd nuclei. The main neutrino reactions for ${}^{92}_{41}$Nb are the charged-current (CC) $^{92}$Zr($\nu_e,e^{-}$)$^{92}$Nb and the neutral-current (NC) $^{93}$Nb(${\nu} ({\bar \nu}), {\nu}^{'} ({\bar \nu})^{'}$ n)$^{92}$Nb reactions. The main reactions for ${}^{98}_{43}$Tc, are the CC reaction $^{98}$Mo($\nu_e,e^-$)$^{98}$Tc and the NC reaction $^{99}$Ru(${\nu} ({\bar \nu}), {\nu}^{'} ({\bar \nu})^{'}$ p)$^{98}$Tc. Our calculations are carried out using the quasi-particle random phase approximation. Numerical results are presented for the energy and temperature dependent cross sections. Since charge exchange reactions by neutrons may also lead to the formation of ${}^{92}_{41}$Nb and ${}^{98}_{43}$Tc, we discuss the feasibility of the $^{92}$Mo(n,p)$^{92}$Nb and $^{98}$Ru(n,p)$^{98}$Tc reactions to produce these nuclei.Comment: 21 pages, 8 figure

A Comparative Study on Histopathological Aspects of Benign and Malignant Smooth Muscle Tumors appeared in Oral Regions

Histopathological aspects of two cases of smooth muscle tumors appeared in oral regions (case 1: angiomyoma; case 2: leiomyosarcoma) have been described. Histopathological features of both cases showed a similarity in terms of relationship with blood vessels. In spite of the changes of cell structure and the destructive pattern of cell proliferation, the results as determined by special staining techniques were the same in the benign and malignant tumors. The histopathological features, origin, and differential diagnosis of the two types of tumors were also discussed

Neutrino self-interaction and MSW effects on the supernova neutrino-process

We calculate the abundances of $^{7}$Li, $^{11}$B, $^{92}$Nb, $^{98}$Tc, $^{138}$La, and $^{180}$Ta produced by neutrino $(\nu)$ induced reactions in a core-collapse supernova explosion. We consider the modification by $\nu$ self-interaction ($\nu$-SI) near the neutrinosphere and the Mikheyev-Smirnov-Wolfenstein effect in outer layers for time-dependent neutrino energy spectra. Abundances of $^{7}$Li and heavy isotopes $^{92}$Nb, $^{98}$Tc and $^{138}$La are reduced by a factor of 1.5-2.0 by the $\nu$-SI. In contrast, $^{11}$B is relatively insensitive to the $\nu$-SI. We find that the abundance ratio of heavy to light nucleus, $^{138}$La/$^{11}$B, is sensitive to the neutrino mass hierarchy, and the normal mass hierarchy is more likely to be consistent with the solar abundances