One-dimensional plasmons in ultrathin metallic silicide wires of finite width

The acoustic dispersion of plasmons (PLs) in narrow (4 nm) and ultrathin (one unit cell) metallic DySi2 wires, grown by self-assembly on vicinal Si(100)-[011] 4° turns out to be unidirectional. We observed the lowest intersubband PL as well as the acoustic PL. These PLs are specific for narrow metallic strips of finite width. Our experimental and theoretical analysis suggests that only one of two electron pockets in the surface Brillouin zone makes a substantial contribution to the PLs because the other pocket has a much smaller conductive character due to a strong admixture of electronic states with d character. © 2010 The American Physical Society

Effect of Ni addition on CPP-GMR response in electrodeposited Co-Ni/Cu multilayered nanocylinders with an ultra-large aspect ratio

Effect of Co–Ni alloy composition on the current perpendicular-to-plane giant magnetoresistance (CPP-GMR) response of electrochemically synthesized Co–Ni/Cu multilayered nanocylinders was studied using anodized aluminum oxide membranes (AAOM) with nanochannel diameterD∼67 nm and length L∼70 μm. Co–Ni/Cu multilayered nanocylinders, which have an aspect ratio L/Dof ∼1,045, were fabricated in theAAOMnanochannel templates by utilizing a pulse-current electrochemical growth process in an electrolytic bath with Co2+,Ni2+ and Cu2+ ions. Co–Ni/Cu alternating structure with Co84Ni16 alloy layer-thickness of 9.6 nmand Cu layer-thickness of 3.8 nm was clearly observed in a nanocylinder with a diameter of 63 nm. The alternating structure was composed from crystalline layers with preferential orientations in hcp-CoNi (002) and fcc-Cu (111). The Co–Ni/Cu multilayered nanocylinders were easily magnetized in the long axis direction because of the extremely large aspect ratio L/D. InCo84Ni16/Cu multilayered nanocylinders, the coercivity and squareness were∼0.46 kOe and∼0.5, respectively. The CPP-GMR value was achieved up to 22.5% (at room temperature) in Co84Ni16/Cu multilayered nanocylinders

STUDY OF THE MECHANISM OF EXPLOSIVE FORCE PRODUCTION ON QUICK LIFT MOTION BY ANALYSIS OF EMG AND MOTION

The aim of this study is to investigate how explosive force exerts during power clean (PC) motion. The subjects are ten skilleds and ten unskilleds. The joint trajectory and EMG during PC are recorded. The joint torque and its rate of torque development (RTD) are calculated from the obtained data. The joint stiffness is estimated from joint stiffness index (JSI) calculated from EMG of agonist and antagonist muscle pair. Experimental results indicated that the skilleds showed the double knee bent that is typically seen in a stretch-shortening cycle (SSC). Skilleds exerted large values of RTD and JSI just after a period of exerting their small values during SSC. It indicates that a much amount of elastic energy stored in a low stiffness state is instantly transferred to the upper segments in the successive high stiffness state by “tenodesis action” of muscles. This is why large RTD generates in the skilled

Irinotecan Hydrochloride (CPT-11) in Dialysis Patients with Gastrointestinal Cancer

We investigated changes in drug disposition and toxicities with CPT-11 in 15 dialysis patients with gastrointestinal cancers to clarify whether CPT-11 could be administered safely in such patients. For comparison, the same parameters were also investigated in 10 cancer patients not undergoing dialysis. Items investigated included (1) plasma concentrations of SN-38, SN-38G and CPT-11 at 0, 1, 12, 24, 36, 48 and 72h after administration, together with a comparison of mean AUC values for 3 dose levels of CPT-11 (50, 60 and 70mg/m2) in dialysis patients and controls;and (2) occurrence of adverse events. Several findings emerged from this study:(1) No significant difference was observed in the AUC for SN-38 or CPT-11 between the dialysis and control groups;(2) The AUC for SN-38G at each dose was significantly higher in dialysis patients;and (3) Grade 1-4 leucopenia was observed in 11 of the dialysis patients. One patient developed grade 4 leucopenia and died due to sepsis. Anorexia, diarrhea, nausea, alopecia and interstitial pneumonia occurred in 6 dialysis patients. We found changes in drug dispositions of CPT-11, SN-38 and SN-38G in dialysis patients, suggesting that hepatic excretion, especially that of SN-38G, was increased. No significant difference in occurrence of adverse events was observed between the 2 groups. This indicates that CPT-11 can be administered safely in patients on dialysis.</p

Micro-patterned culture of iPSC-derived alveolar and airway cells distinguishes SARS-CoV-2 variants.

iPS細胞から作った肺胞や気道の細胞によりSARS-CoV-2変異株の病原性を比較評価する. 京都大学プレスリリース. 2024-03-29.Micro-patterning a new system to induce alveolar and airway epithelial cells. 京都大学プレスリリース. 2024-03-29.The emergence of severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) variants necessitated a rapid evaluation system for their pathogenesis. Lung epithelial cells are their entry points; however, in addition to their limited source, the culture of human alveolar epithelial cells is especially complicated. Induced pluripotent stem cells (iPSCs) are an alternative source of human primary stem cells. Here, we report a model for distinguishing SARS-CoV-2 variants at high resolution, using separately induced iPSC-derived alveolar and airway cells in micro-patterned culture plates. The position-specific signals induced the apical-out alveolar type 2 and multiciliated airway cells at the periphery and center of the colonies, respectively. The infection studies in each lineage enabled profiling of the pathogenesis of SARS-CoV-2 variants: infection efficiency, tropism to alveolar and airway lineages, and their responses. These results indicate that this culture system is suitable for predicting the pathogenesis of emergent SARS-CoV-2 variants