4 research outputs found
Sindrom Al'strema u podrostkov (pervoe opisanie v Rossii)
Π‘ΠΈΠ½Π΄ΡΠΎΠΌ ΠΠ»ΡΡΡΡΠ΅ΠΌΠ° Π²ΠΏΠ΅ΡΠ²ΡΠ΅ Π±ΡΠ» ΠΎΠΏΠΈΡΠ°Π½ Π² 1959 Π³. ΠΡΠ½ΠΎΠ²Π½ΡΠΌΠΈ ΡΠΈΠΌΠΏΡΠΎΠΌΠ°ΠΌΠΈ ΡΡΠΎΠ³ΠΎ ΠΏΡΠΎΠ³ΡΠ΅ΡΡΠΈΡΡΡΡΠ΅Π³ΠΎ Π°ΡΡΠΎΡΠΎΠΌΠ½ΠΎ-ΡΠ΅ΡΠ΅ΡΡΠΈΠ²Π½ΠΎΠ³ΠΎ ΡΠ°ΡΡΡΡΠΎΠΉΡΡΠ²Π° ΡΠ²Π»ΡΡΡΡΡ Π²ΡΠΎΠΆΠ΄Π΅Π½Π½Π°Ρ Π΄Π΅Π³Π΅Π½Π΅ΡΠ°ΡΠΈΡ ΡΠ΅ΡΡΠ°ΡΠΊΠΈ, Π²Π΅Π΄ΡΡΠ°Ρ ΠΊ ΡΠ»Π΅ΠΏΠΎΡΠ΅, Π΄Π΅ΡΡΠΊΠΎΠ΅ ΠΎΠΆΠΈΡΠ΅Π½ΠΈΠ΅, ΡΠ°Ρ
Π°ΡΠ½ΡΠΉ Π΄ΠΈΠ°Π±Π΅Ρ 2 ΡΠΈΠΏΠ° (Π‘Π2). ΠΠ°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΠ΅ Π²ΡΡΡΠ΅ΡΠ°Π΅ΡΡΡ ΡΡΠ΅Π΄ΠΈ ΡΠ°Π·Π»ΠΈΡΠ½ΡΡ
ΡΠ°Ρ ΠΈ ΡΡΠ½ΠΈΡΠ΅ΡΠΊΠΈΡ
Π³ΡΡΠΏΠΏ. ΠΠ·Π²Π΅ΡΡΠ½Ρ ΡΠ΄Π΅ΡΠ½ΡΠ΅ ΡΠ΅ΠΌΡΠΈ (2?3 ΠΏΠΎΡΠ°ΠΆΠ΅Π½Π½ΡΡ
ΡΠ΅Π±Π΅Π½ΠΊΠ°). Π§Π°ΡΡΠΎΡΠ° ΡΠΈΠ½Π΄ΡΠΎΠΌΠ° Π² ΠΏΠΎΠΏΡΠ»ΡΡΠΈΠΈ ΠΎΡΡΠ°Π΅ΡΡΡ Π½Π΅ΠΈΠ·Π²Π΅ΡΡΠ½ΠΎΠΉ. ΠΠΎΠ»ΠΈΠΌΠΎΡΡΠΈΠ·ΠΌ ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΎΠΉ ΠΊΠ°ΡΡΠΈΠ½Ρ ΡΠΈΠ½Π΄ΡΠΎΠΌΠ° ΠΠ»ΡΡΡΡΠ΅ΠΌΠ°, ΡΡ
ΠΎΠ΄Π½ΠΎΠΉ Ρ ΠΌΠ½ΠΎΠ³ΠΈΠΌΠΈ Π΄ΡΡΠ³ΠΈΠΌΠΈ Π³Π΅Π½Π΅ΡΠΈΡΠ΅ΡΠΊΠΈΠΌΠΈ ΡΠΈΠ½Π΄ΡΠΎΠΌΠ°ΠΌΠΈ, Π·Π°ΡΡΡΠ΄Π½ΡΠ΅Ρ Π΄ΠΈΠ°Π³Π½ΠΎΡΡΠΈΠΊΡ. ΠΠ΄Π½Π°ΠΊΠΎ ΠΌΠΎΠ»Π΅ΠΊΡΠ»ΡΠ½ΠΎ-Π³Π΅Π½Π΅ΡΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ ΡΠΏΠΎΡΠΎΠ±ΡΡΠ²ΡΡΡ ΡΠ°Π½Π½Π΅ΠΌΡ Π²ΡΡΠ²Π»Π΅Π½ΠΈΡ Π΄Π°Π½Π½ΠΎΠ³ΠΎ ΡΠΈΠ½Π΄ΡΠΎΠΌΠ°
Association of type 1 diabetes mellitus (DM1) with polymorphous alleles of HLA-DR and DQ genes in two Russian populations of Moscow and Vologda regions
Aim.
To consider association of type 1 diabetes mellitus (DM1) with polymorphous alleles of HLA-DRB1 HLA-DQB1, and DQA1 genes in two Russian populations of Moscow (MP) and Vologda (VP) regions.
Materials and methods.
Identification of alleles of HLA-DRB1 HLA-DQB1, and DQA1 genes in 138 patients with type 1 diabetes and a random sample of 242 subjects from the local population (residents in at least three successive generations) of the Vologda region, 204 patients and a random sample of 300 subjects from the city of Moscow and Moscow region.
Results.
MP and VP exhibited identical predisposing alleles. The occurrence of DRB1*4 (RR=5.96 and 3.93 in MP and VP respectively), DRB1*17 (RR=4.33 and 4.23), DQA1*0301 (RR=5.70 and 3.66), DQB1*0201, (RR=2.06 and 1.77), DQB1* 0302 (RR=7.10 and 3.95), DQB1* 0304 (RR=8.94 and 19.98) alleles was significantly higher in DM1 patients. The following protective alleles were identified in MP and VP respectively: DRB1*7 (RR=0.37 and 0.18), DRB1*11 (RR=0.12 and 0.21), DRB1*13 (RR=0.09 and 0.26), DRB1*15 (RR=0.23 and 0.04), DQA1*0102 (RR=0.29 and 0.23), DQA1*0103 (RR=0.13 and 0.23), DQA1*0201 (RR=0.37 and 0.17), DQb1*0301 (RR=0.16 and 0.24), and DQB1*0602/8 (RR=0.10 and 0.13).
Conclusion.
?New? associations unknown in other populations (e.g. DQB1*0304) were revealed, besides the majority of classical predisposing and protective alleles characteristic of European populations. DQB1*0304 proved the strongest predisposing allele in MP and especially in VP. These data suggest different contribution of predisposing alleles to the development of DM1 in individual populations
Assotsiatsiya khromosomnoy oblasti 5q31.1-q33.1 (IDDM18) s sakharnym diabetom 1 tipa sredi russkogo naseleniya g. Moskvy
Π¦Π΅Π»Ρ. ΠΡΡΠ»Π΅Π΄ΠΎΠ²Π°ΡΡ Π²ΠΎΠ·ΠΌΠΎΠΆΠ½ΠΎΠ΅ Π²Π»ΠΈΡΠ½ΠΈΠ΅ Π»ΠΎΠΊΡΡΠ° IDDM18 Π½Π° ΠΏΡΠ΅Π΄ΡΠ°ΡΠΏΠΎΠ»ΠΎΠΆΠ΅Π½Π½ΠΎΡΡΡ ΠΊ Π‘Π1 Π² ΡΠ΅ΠΌΡΡΡ
ΠΈΠ· ΡΡΡΡΠΊΠΎΠΉ ΠΏΠΎΠΏΡΠ»ΡΡΠΈΠΈ. ΠΠ°ΡΠ΅ΡΠΈΠ°Π»Ρ ΠΈ ΠΌΠ΅ΡΠΎΠ΄Ρ. ΠΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½Ρ ΠΠΠ Π΄Π²ΡΡ
Π³ΡΡΠΏΠΏ ΡΠ΅ΠΌΠ΅ΠΉ ΠΈΠ· Π³ΠΎΡΠΎΠ΄ΡΠΊΠΈΡ
ΠΏΠΎΠΏΡΠ»ΡΡΠΈΠΉ ΠΠΎΡΠΊΠ²Ρ ΠΈ Π‘Π°ΠΌΠ°ΡΡ, Ρ ΠΊΠΎΠ½ΠΊΠΎΡΠ΄Π°Π½ΡΠ½ΡΠΌΠΈ (27 ΡΠ΅ΠΌΠ΅ΠΉ) ΠΈ Π΄ΠΈΡΠΊΠΎΡΠ΄Π°Π½ΡΠ½ΡΠΌΠΈ (62 ΡΠ΅ΠΌΡΠΈ) ΠΏΠ°ΡΠ°ΠΌΠΈ ΡΠΈΠ±ΡΠΎΠ². ΠΡΠ΄Π΅Π»ΡΠ»ΠΈ Π³Π΅Π½ΠΎΠΌΠ½ΡΡ ΠΠΠ ΠΈΠ· ΠΊΡΠΎΠ²ΠΈ Π±ΠΎΠ»ΡΠ½ΡΡ
, ΠΎΠΏΡΠ΅Π΄Π΅Π»ΡΠ»ΠΈ Π³Π΅Π½ΠΎΡΠΈΠΏΡ ΠΏΠΎΠ»ΠΈΠΌΠΎΡΡΠ½ΡΡ
ΠΌΠ°ΡΠΊΠ΅ΡΠΎΠ². ΠΠΌΠΏΠ»ΠΈΡΠΈΡΠΈΡΠΎΠ²Π°Π½Π½ΡΠ΅ ΡΡΠ°Π³ΠΌΠ΅Π½ΡΡ ΠΠΠ, ΡΠΎΠ΄Π΅ΡΠΆΠ°ΡΠΈΠ΅ ΠΏΠΎΠ»ΠΈΠΌΠΎΡΡΠ½ΡΠ΅ ΠΌΠ°ΡΠΊΠ΅ΡΡ, ΡΠ°Π·Π΄Π΅Π»ΡΠ»ΠΈ Π² 10% ΠΏΠΎΠ»ΠΈΠ°ΠΊΡΠΈΠ»Π°ΠΌΠΈΠ΄Π½ΠΎΠΌ Π³Π΅Π»Π΅ Ρ ΠΏΠΎΡΠ»Π΅Π΄ΡΡΡΠ΅ΠΉ ΠΎΠΊΡΠ°ΡΠΊΠΎΠΉ Π°Π·ΠΎΡΠ½ΠΎΠΊΠΈΡΠ»ΡΠΌ ΡΠ΅ΡΠ΅Π±ΡΠΎΠΌ. Π€ΡΠ°Π³ΠΌΠ΅Π½ΡΡ ΠΠΠ, ΡΠΎΠ΄Π΅ΡΠΆΠ°ΡΠΈΠ΅ ΠΏΠΎΠ»ΠΈΠΌΠΎΡΡΠ½ΡΠ΅ ΠΌΠ°ΡΠΊΠ΅ΡΡ, Π°ΠΌΠΏΠ»ΠΈΡΠΈΡΠΈΡΠΎΠ²Π°Π»ΠΈ Ρ ΠΏΠΎΠΌΠΎΡΡΡ ΠΠ¦Π ΠΈ Π·Π°ΡΠ΅ΠΌ ΠΈΠ½ΠΊΡΠ±ΠΈΡΠΎΠ²Π°Π»ΠΈ Π² ΡΠ΅ΡΠ΅Π½ΠΈΠ΅ 2?4 Ρ Ρ ΡΠ΅ΡΡΡΠΈΠΊΡΠ°Π·ΠΎΠΉ, ΡΠ°ΡΡΠ΅ΠΏΠ»ΡΡΡΠ΅ΠΉ Π΄Π°Π½Π½ΡΠΉ ΡΡΠ°Π³ΠΌΠ΅Π½Ρ Π² ΡΠ»ΡΡΠ°Π΅ Π½Π°Π»ΠΈΡΠΈΡ Π² Π½Π΅ΠΌ Π°Π»Π»Π΅Π»Ρ A. ΠΠ½Π°Π»ΠΈΠ· Π°ΡΡΠΎΡΠΈΠ°ΡΠΈΠΈ ΠΊΠΎΠ½ΠΊΠΎΡΠ΄Π°Π½ΡΠ½ΡΡ
ΠΈ Π΄ΠΈΡΠΊΠΎΡΠ΄Π°Π½ΡΠ½ΡΡ
ΡΠ΅ΠΌΠ΅ΠΉ ΠΏΡΠΎΠ²ΠΎΠ΄ΠΈΠ»ΠΈ Ρ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ΠΈΠ΅ΠΌ ΠΎΠ±ΡΠ΅Π΄ΠΈΠ½Π΅Π½Π½ΠΎΠ³ΠΎ ΡΠ΅ΡΡΠ° TDT (Transmission Disequlibrium Test) ΠΈ S-TDT (Sib Transmission Disequlibrium Test). Π Π΅Π·ΡΠ»ΡΡΠ°ΡΡ. ΠΠΈ Π΄Π»Ρ ΠΎΠ΄Π½ΠΎΠ³ΠΎ ΠΈΠ· ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½Π½ΡΡ
ΠΏΠΎΠ»ΠΈΠΌΠΎΡΡΠ½ΡΡ
ΠΌΠ°ΡΠΊΠ΅ΡΠΎΠ² Π½Π΅ Π±ΡΠ»ΠΎ ΠΏΠΎΠΊΠ°Π·Π°Π½ΠΎ ΠΏΡΠ΅Π΄ΠΏΠΎΠ»ΠΎΠΆΠΈΡΠ΅Π»ΡΠ½ΠΎΠ³ΠΎ ΡΡΠ΅ΠΏΠ»Π΅Π½ΠΈΡ (MLS>2,20) Ρ Π‘Π1 Π² ΠΏΠΎΠΏΡΠ»ΡΡΠΈΠΈ Π±ΠΎΠ»ΡΠ½ΡΡ
ΡΡΡΡΠΊΠΎΠ³ΠΎ ΠΏΡΠΎΠΈΡΡ
ΠΎΠΆΠ΄Π΅Π½ΠΈΡ. Π‘ΡΠ°ΡΠΈΡΡΠΈΡΠ΅ΡΠΊΠΈ Π·Π½Π°ΡΠΈΠΌΠ°Ρ Π°ΡΡΠΎΡΠΈΠ°ΡΠΈΡ Π½Π΅ Π±ΡΠ»Π° ΠΏΠΎΠΊΠ°Π·Π°Π½Π° Π½ΠΈ Π΄Π»Ρ ΠΎΠ΄Π½ΠΎΠ³ΠΎ ΠΈΠ· ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½Π½ΡΡ
ΠΌΠ°ΡΠΊΠ΅ΡΠΎΠ². Π’Π°ΠΊΠΈΠΌ ΠΎΠ±ΡΠ°Π·ΠΎΠΌ, ΡΠ΅ΡΡ TDT ΠΏΠΎΠ΄ΡΠ²Π΅ΡΠ΄ΠΈΠ» ΠΎΡΡΡΡΡΡΠ²ΠΈΠ΅ ΡΠ²ΡΠ·ΠΈ Π»ΠΎΠΊΡΡΠ° IDDM18 Ρ Π‘Π1 Π² ΡΡΡΡΠΊΠΎΠΉ ΠΏΠΎΠΏΡΠ»ΡΡΠΈΠΈ Π±ΠΎΠ»ΡΠ½ΡΡ
. ΠΡΠ²ΠΎΠ΄Ρ. Π£ Π±ΠΎΠ»ΡΠ½ΡΡ
Π‘Π1 ΡΡΡΡΠΊΠΎΠ³ΠΎ ΠΏΡΠΎΠΈΡΡ
ΠΎΠΆΠ΄Π΅Π½ΠΈΡ Π½Π΅ ΠΎΠ±Π½Π°ΡΡΠΆΠ΅Π½ΠΎ ΡΡΠ΅ΠΏΠ»Π΅Π½ΠΈΡ ΠΈ Π°ΡΡΠΎΡΠΈΠ°ΡΠΈΠΈ Π»ΠΎΠΊΡΡΠ° IDDM18 Ρ Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΠ΅ΠΌ
Association of type 1 diabetes mellitus (DM1) with polymorphous alleles of class II HLA genes in Yakutian and Russian populations
Materials and methods. HLA genotyping was accomplished in 51 DM1 patients and 51 volunteers randomly selected from the indigenous populationof Yakutia (Yakuts in three successive generations). Another 205 DM1 patients and 300 healthy subjects comprised random samples of patients andcontrols respectively from residents of Moscow and Moscow region.
Results.
HLA DRB1*17(03) allele proved to be the strongest one predisposing to DM1 in the Yakutian population (relative risk, RR=8,47) andDQB1*0304 in the Moscow population (RR=8,94). The presence of DRB1*04, DRB1*17(03), DQA1*0301, DQB1*0201, and DQB1*0302 accountedfor RR >2 in both populations. Only two alleles, DRB1*04 and DRB17(03), in the Yakutian population and five of the six (DRB1*04,DRB1*17(03), DQA1*(0301), DQB1*0302, and DQB1*0304) in the Moscow one were closely associated with DM1 (RR >4). DRB1*09, DRB1*11,DQB1*13, DQB1*0602/8 in Yakutian and DRB1*11, DRB1*13, DQA1*0103, DQB1*0301, DQB1*0602/8 in Moscow populations had the highestprotective potential (R