10 research outputs found
PHP219 Off-Label Use of Intravenous Immunoglogulins (IVIGS): Funding Mechanisms in France, Germany, Italy, Spain and the United Kingdom (EU5)
Get PDFSyntheses of Combretastatin A‐4 and Related Stilbenes by Using Aqueous Conditions
Get PDFCombretastatin A-4 (CA4) is a potent anti-mitotic and vascular disrupting agent. Organic chemists have been working to optimize the synthesis of CA4 for the past 3 decades, with methods requiring hazardous solvents and harsh reaction conditions. Here, we report the synthesis of CA4 and a variety of stilbenes in an aqueous Wittig system. Potassium carbonate or lithium hydroxide were used as base in this Wittig reaction to give excellent yields of mixtures of E- and Z-stilbenes. The synthesis of CA4 was achieved using tetrahydropyran (THP) or silyl protected phenolic aldehydes. The THP groups were removed using dilute acid whilst the silyl groups fortuitously fell off during work up
An Assessment of the Impact of Biosimilars on Access to Biologics Based on Primary Research, System Dynamics Modelling, and War Gaming
No full textSubstantial genetic diversity in cultivated Moroccan olive despite a single major cultivar: a paradoxical situation evidenced by the use of SSR loci
No full textMolecular markers: an important tool to analyze the genetic diversity of local Tunisian olive varieties
No full textBayesian and Phylogenic Approaches for Studying Relationships among Table Olive Cultivars
No full textSNP Discovery by Illumina-Based Transcriptome Sequencing of the Olive and the Genetic Characterization of Turkish Olive Genotypes Revealed by AFLP, SSR and SNP Markers
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