122 research outputs found

    Effect of tool surface topography on friction with carbon fibre tows for composite fabric forming

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    The effect of tool surface roughness topography on tow-on-tool friction relevant to the dry forming of composite fabrics is investigated. A comprehensive range of tool average surface roughness Ra_a values from 0.005 to 3.2 ÎŒ\mum was used in friction testing with carbon fibre tows. The measured slope of these surfaces, which is the critical surface topographical characteristic, increased significantly with increasing roughness amplitude. Friction was found to be sensitive to roughness topography for very smooth surfaces (Ra_a 0.1 ÎŒ\mum), friction was relatively insensitive to roughness slope and amplitude. A finite element idealisation of the tow-on-tool contact was used to explain these results in terms of the level of tow-tool conformance. Smooth surfaces have low slopes which allow good conformance, and hence high real contact area and friction. Rougher surfaces have high slopes, particularly at shorter wavelengths, which prevents good conformance. In this case, point contact between fibres and surface dominates, leaving the resulting friction less sensitive to roughness.The authors would like to acknowledge the assistance of the Engineering and Physical Sciences Research Council (EPSRC) for supporting the present work under grant Ref. EP/K032798/1 (Friction in Composites Forming). We would also like to acknowledge the contribution of our industrial collaborators at Jaguar Land Rover and Granta Design Ltd, as well as our academic partners from the Composites Research Group at the University of Nottingham (Prof. Andy Long, Prof. Nick Warrior and Prof. Davide De Focatiis). Dr Olga Smerdova of ‘‘Institut PPrime”, ISAE-ENSMA, Poitiers is thanked for useful discussions throughout the work. Hexcel are thanked for supplying the tow material

    Friction of carbon fibre tows

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    The fundamental frictional behaviour of carbon fibre tows relevant to composite fabric forming is explored. Tow-on-tool and tow-on-tow contact are considered. For tow-on-tool contact, an experiment is devised to simultaneously observe the true filament contact length and measure the friction force over a range of normal loads. Filament contact length is not constant, as would be given from an idealised assumption of parallel touching filaments, but increases in a characteristic manner with normal load. Friction force follows a power law variation with normal load with exponent in the range 0.7–1. Accounting for the evolving contact length in a Hertzian calculation of the real contact area produces a contact area versus load variation which differs only by a constant factor from the measured friction force curves. Thus, the results agree with a ‘constant interface strength’ model of friction. Tow orientation and sizing are found to have a significant effect on friction by altering the real contact area.Engineering and Physical Sciences Research Council (Grant ID: EP/K032798/1 (Friction in Composites Forming)), Jaguar Land Rover, Granta Design Ltd, Composites Research Group at the University of Nottingham, Hexcel U

    Frictional behaviour of non-crimp fabrics (NCFs) in contact with a forming tool

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    Microscopic observation and analysis are used to examine the role that contact conditions play in determining the frictional behaviour of non-crimp fabrics (NCFs). The true fibre contact length is measured over a range of normal pressures. For the NCF considered, the contact length is 67% lower than for a corresponding unidirectional tow-on-tool contact at a pressure of 240 kPa. The difference in contact behaviour is associated with the fabric architecture, specifically stitching and gaps between tows. These microscopic observations are used to predict friction using a constant interface shear strength model. These predictions are found to compare well with macroscopic friction measurements taken using a sliding sled arrangement, once the roughness of the sled tool is taken into account

    Alcohol affects neuronal substrates of response inhibition but not of perceptual processing of stimuli signalling a stop response

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    Alcohol impairs inhibitory control, including the ability to terminate an initiated action. While there is increasing knowledge about neural mechanisms involved in response inhibition, the level at which alcohol impairs such mechanisms remains poorly understood. Thirty-nine healthy social drinkers received either 0.4g/kg or 0.8g/kg of alcohol, or placebo, and performed two variants of a Visual Stop-signal task during acquisition of functional magnetic resonance imaging (fMRI) data. The two task variants differed only in their instructions: in the classic variant (VSST), participants inhibited their response to a “Go-stimulus” when it was followed by a “Stop-stimulus”. In the control variant (VSST_C), participants responded to the “Go-stimulus” even if it was followed by a “Stop-stimulus”. Comparison of successful Stop-trials (Sstop)>Go, and unsuccessful Stop-trials (Ustop)>Sstop between the three beverage groups enabled the identification of alcohol effects on functional neural circuits supporting inhibitory behaviour and error processing. Alcohol impaired inhibitory control as measured by the Stop-signal reaction time, but did not affect other aspects of VSST performance, nor performance on the VSST_C. The low alcohol dose evoked changes in neural activity within prefrontal, temporal, occipital and motor cortices. The high alcohol dose evoked changes in activity in areas affected by the low dose but importantly induced changes in activity within subcortical centres including the globus pallidus and thalamus. Alcohol did not affect neural correlates of perceptual processing of infrequent cues, as revealed by conjunction analyses of VSST and VSST_C tasks. Alcohol ingestion compromises the inhibitory control of action by modulating cortical regions supporting attentional, sensorimotor and action-planning processes. At higher doses the impact of alcohol also extends to affect subcortical nodes of fronto-basal ganglia- thalamo-cortical motor circuits. In contrast, alcohol appears to have little impact on the early visual processing of infrequent perceptual cues. These observations clarify clinically-important effects of alcohol on behaviour

    Measuring kinetic drivers of pneumolysin pore structure

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    Most membrane attack complex-perforin/cholesterol-dependent cytolysin (MACPF/CDC) proteins are thought to form pores in target membranes by assembling into pre-pore oligomers before undergoing a pre-pore to pore transition. Assembly during pore formation is into both full rings of subunits and incomplete rings (arcs). The balance between arcs and full rings is determined by a mechanism dependent on protein concentration in which arc pores arise due to kinetic trapping of the pre-pore forms by the depletion of free protein subunits during oligomerisation. Here we describe the use of a kinetic assay to study pore formation in red blood cells by the MACPF/CDC pneumolysin from Streptococcus pneumoniae. We show that cell lysis displays two kinds of dependence on protein concentration. At lower concentrations it is dependent on the pre-pore topore transition of arc oligomers, which we show to be a cooperative process. At higher concentrations it is dependent on the amount of pneumolysin bound to the membrane and reflects the affinity of the protein for its receptor, cholesterol. A lag occurs before cell lysis begins; this is dependent on oligomerisation of pneumolysin. Kinetic dissection of cell lysis by pneumolysin demonstrates the capacity of MACPF/CDCs to generate pore-forming oligomericstructures of variable size with, most likely, different functional roles in biology

    Design of bio-nanosystems for oral delivery of functional compounds

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    Nanotechnology has been referred to as one of the most interesting topics in food technology due to the potentialities of its use by food industry. This calls for studying the behavior of nanosystems as carriers of biological and functional compounds aiming at their utilization for delivery, controlled release and protection of such compounds during food processing and oral ingestion. This review highlights the principles of design and production of bio-nanosystems for oral delivery and their behavior within the human gastrointestinal (GI) tract, while providing an insight into the application of reverse engineering approach to the design of those bio-nanosystems. Nanocapsules, nanohydrogels, lipid-based and multilayer nanosystems are discussed (in terms of their main ingredients, production techniques, predominant forces and properties) and some examples of possible food applications are given. Phenomena occurring in in vitro digestion models are presented, mainly using examples related to the utilization of lipid-based nanosystems and their physicochemical behavior throughout the GI tract. Furthermore, it is shown how a reverse engineering approach, through two main steps, can be used to design bio-nanosystems for food applications, and finally a last section is presented to discuss future trends and consumer perception on food nanotechnology.Miguel A. Cerqueira, Ana C. Pinheiro, Helder D. Silva, Philippe E. Ramos, Ana I. Bourbon, Oscar L. Ramos (SFRH/BPD/72753/2010, SFRH/BD/48120/2008, SFRH/BD/81288/2011, SFRH/BD/80800/2011, SFRH/BD/73178/2010 and SFRH/BPD/80766/2011, respectively) are the recipients of a fellowship from the Fundacao para a Ciencia e Tecnologia (FCT, POPH-QREN and FSE Portugal). Maria L. Flores-Lopez thanks Mexican Science and Technology Council (CONACYT, Mexico) for PhD fellowship support (CONACYT Grant number: 215499/310847). The support of EU Cost Actions FA0904 and FA1001 is gratefully acknowledged

    Effect of tool surface topography on friction with carbon fibre tows for composite fabric forming

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    The effect of tool surface roughness topography on tow-on-tool friction relevant to the dry forming of composite fabrics is investigated. A comprehensive range of tool average surface roughness Ra_a values from 0.005 to 3.2 Ό\mum was used in friction testing with carbon fibre tows. The measured slope of these surfaces, which is the critical surface topographical characteristic, increased significantly with increasing roughness amplitude. Friction was found to be sensitive to roughness topography for very smooth surfaces (Ra_a 0.1 Ό\mum), friction was relatively insensitive to roughness slope and amplitude. A finite element idealisation of the tow-on-tool contact was used to explain these results in terms of the level of tow-tool conformance. Smooth surfaces have low slopes which allow good conformance, and hence high real contact area and friction. Rougher surfaces have high slopes, particularly at shorter wavelengths, which prevents good conformance. In this case, point contact between fibres and surface dominates, leaving the resulting friction less sensitive to roughness

    Friction of carbon fibre tows

    No full text
    The fundamental frictional behaviour of carbon fibre tows relevant to composite fabric forming is explored. Tow-on-tool and tow-on-tow contact are considered. For tow-on-tool contact, an experiment is devised to simultaneously observe the true filament contact length and measure the friction force over a range of normal loads. Filament contact length is not constant, as would be given from an idealised assumption of parallel touching filaments, but increases in a characteristic manner with normal load. Friction force follows a power law variation with normal load with exponent in the range 0.7–1. Accounting for the evolving contact length in a Hertzian calculation of the real contact area produces a contact area versus load variation which differs only by a constant factor from the measured friction force curves. Thus, the results agree with a ‘constant interface strength’ model of friction. Tow orientation and sizing are found to have a significant effect on friction by altering the real contact area
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