22 research outputs found

    DNA G-quadruplexes in the human genome: detection, functions and therapeutic potential.

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    Single-stranded guanine-rich DNA sequences can fold into four-stranded DNA structures called G-quadruplexes (G4s) that arise from the self-stacking of two or more guanine quartets. There has been considerable recent progress in the detection and mapping of G4 structures in the human genome and in biologically relevant contexts. These advancements, many of which align with predictions made previously in computational studies, provide important new insights into the functions of G4 structures in, for example, the regulation of transcription and genome stability, and uncover their potential relevance for cancer therapy.The Balasubramanian laboratory is core-funded by Cancer Research UK (C14303/A17197) and further supported by a Cancer Research UK programme grant (C9681/A18618). S.B. is a Wellcome Trust Senior Investigator (099232/Z/12/Z)

    Oral History Interview with Morton H. Meyerson, March 2-April 26, 2021

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    Video recording of a series of interviews with Morton H. Meyerson, Dallas-based business leader and philanthropist. Meyerson shares concerning his grandparents’ experiences in present-day Belarus and Prussia and as immigrants to the U.S. and eventually to Fort Worth; parents’ experiences growing up in Fort Worth; Education in Fort Worth public schools culminating at Paschal High School and at UT-Austin; experiences in U.S. Army; Career as a systems engineer at Bell Helicopter, Electronic Data Systems, General Motors, Perot Systems, and other;. Experiences as a philanthropist, including chair of the committee responsible for constructing what became the Meyerson Symphony Center, and as a civic leader, including chair of the committee that brought the superconducting supercollider to Texas

    2010 WI Oral History Day - Milwaukee, WI

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    Selections from the 2010 WI Oral History Day Conference held March 28-28, 2010 in Milwaukee, WI. Topics include Hmong Diaspora Studies, overcoming stereotypes, cross-cultural and cross-generational interviewing, Tuskeegee Airmen narratives, and using humor to deal with racism
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