Talento humano: el factor clave del servicio

Esta investigación se centra en el reconocimiento del Talento Humano como el factor más importante para el servicio de una organización incluyendo el análisis del servicio y cultura organizacional en el siglo XXI. Se ilustran algunos mecanismos o programas sobre la gestión que una organización debe desarrollar para obtener un Talento Humano calificado y competente en temas de servicio y concluyentes como la transformación de una cultura organizacional centrada en valores, normas y principios, complementados con herramientas efectivas de comunicación y consecución de líderes modernos e innovadores en temas de servicio. El Talento Humano resalta la prioridad que tienen las organizaciones que están volcadas al cliente que cada día adquieren vigencia y relevancia para lograr ser competitivas en donde se mueven. Por otro lado, el Talento Humano se convierte en la cara de la empresa siendo los máximos vendedores de sus bienes y servicios, para lo cual se debe crear una cultura organizacional con tiempo, constancia y perseverancia. La metodología utilizada fue de investigación deductiva incluyendo charlas con personas expertas en el tema de servicio, así como la experiencia propia en empresas de servicios y de industria y comercio. De esta manera se logró establecer una serie de principios y normas de conducta que debe tener el Talento Humano para que una organización sea reconocida como una empresa con una fuerte cultura de servicio.This research focuses on the recognition of human talent as the most important factor for the service of an organization including service analysis and organizational culture in the twenty-first century. It illustrates some mechanisms or management programs that an organization must develop to get a qualified and competent human talent in services areas and conclusive as the transformation of an organizational culture focused on values, norms and principles, complemented with effective communication tools and achievement of modern and innovative leaders in the areas of service. The Human Talent highlights the priority as organizations that are geared towards the customer which are now gaining currency and relevance in order to become competitive. On the other hand, the human talent becomes the face of the company being the highest sellers of their goods and services, for which the company must create an organizational culture with time, persistence and perseverance. The research methodology was deductive including interviews with experts on the topic of service as well as our own experience in services and trade and industry companies. In this way it was possible to establish a set of principles and conduct rules the human talent must have in the organization to be recognized as a strong culture of service company

Broccoli and Radish Sprouts are Safe and Rich in Bioactive Phytochemicals

©. This manuscript version is made available under the CC-BY-NC-ND license http://creativecommons.org/licenses/cc-by-nc-nd /4.0/ This document is the Acepted version of a Published Work that appeared in final form in [Postharvest Biology and Technology]. To access the final edited and published work see [https://doi.org/10.1016/j.postharvbio.2017.01.010]Cruciferous sprouts (e.g. broccoli and red radish) are rich source of health-promoting phytochemicals more concentrated than the adult plant edible organs; however, these tiny microgreens need cold storage conditions to preserve their quality to reach the consumers in microbiologically safe conditions, maintaining their composition and acceptability. In this work, the microbiological status and phytochemical composition of broccoli and radish sprouts were evaluated at harvest (Day 0), and after seven and fourteen days of storage at two different temperatures, 5 and 10 °C. Pathogenic microorganisms were absent during shelf-life; nevertheless, the slight growth of Enterobacteriaceae organisms, aerobic mesophilic and psychrotrophic bacteria, molds and yeasts was assessed. The temperature of storage highly influenced the quality and content of bioactives in the sprouts, and for practical applications, the storage at 5 ºC is the most suitable option. Moreover, these fresh crucifers remain acceptable for consumers after a long refrigerated storage period (14 d), being an interesting option for consuming fresh and naturally-functional foods

Utilización del grano de soya crudo en la alimentación de cerdas primerizas, durante dos periodos consecutivos de gestación - lactancia

Con 21 cerdas primerizas cruzadas se evaluaron los efectos del suministro del grano de soya crudo en reemplazo de la soya integral cocida y de la torta de soya durante dos períodos consecutivos. No hubo diferencia al parto (P and lt; 0.05) en las variables cambio de peso de la cerda, peso de lechones al nacimiento y a los 7 días, porcentaje de mortalidad a los 7, excepto para el número de lechones nacidos vivos. En lactancia, hubo diferencias (PCrossbred gilts were used to evaluate the effect in gestation-lactation due to feeding with raw soybean grain replacing cooked whole grain soybean and soybean meal during two consecutive periods. There were ne differences at farrowing (

Utilización del grano de soya crudo en la alimentación de cerdas primerizas, durante dos periodos consecutivos de gestación - lactancia

Con 21 cerdas primerizas cruzadas se evaluaron los efectos del suministro del grano de soya crudo en reemplazo de la soya integral cocida y de la torta de soya durante dos períodos consecutivos. No hubo diferencia al parto (P and lt; 0.05) en las variables cambio de peso de la cerda, peso de lechones al nacimiento y a los 7 días, porcentaje de mortalidad a los 7, excepto para el número de lechones nacidos vivos. En lactancia, hubo diferencias (PCrossbred gilts were used to evaluate the effect in gestation-lactation due to feeding with raw soybean grain replacing cooked whole grain soybean and soybean meal during two consecutive periods. There were ne differences at farrowing (

Cannabinoids reduce ErbB2-driven breast cancer progression through Akt inhibition.

RIGHTS : This article is licensed under the BioMed Central licence at http://www.biomedcentral.com/about/license which is similar to the 'Creative Commons Attribution Licence'. In brief you may : copy, distribute, and display the work; make derivative works; or make commercial use of the work - under the following conditions: the original author must be given credit; for any reuse or distribution, it must be made clear to others what the license terms of this work are.BACKGROUND: ErbB2-positive breast cancer is characterized by highly aggressive phenotypes and reduced responsiveness to standard therapies. Although specific ErbB2-targeted therapies have been designed, only a small percentage of patients respond to these treatments and most of them eventually relapse. The existence of this population of particularly aggressive and non-responding or relapsing patients urges the search for novel therapies. The purpose of this study was to determine whether cannabinoids might constitute a new therapeutic tool for the treatment of ErbB2-positive breast tumors. We analyzed their antitumor potential in a well established and clinically relevant model of ErbB2-driven metastatic breast cancer: the MMTV-neu mouse. We also analyzed the expression of cannabinoid targets in a series of 87 human breast tumors. RESULTS: Our results show that both Delta9-tetrahydrocannabinol, the most abundant and potent cannabinoid in marijuana, and JWH-133, a non-psychotropic CB2 receptor-selective agonist, reduce tumor growth, tumor number, and the amount/severity of lung metastases in MMTV-neu mice. Histological analyses of the tumors revealed that cannabinoids inhibit cancer cell proliferation, induce cancer cell apoptosis, and impair tumor angiogenesis. Cannabinoid antitumoral action relies, at least partially, on the inhibition of the pro-tumorigenic Akt pathway. We also found that 91% of ErbB2-positive tumors express the non-psychotropic cannabinoid receptor CB2. CONCLUSIONS: Taken together, these results provide a strong preclinical evidence for the use of cannabinoid-based therapies for the management of ErbB2-positive breast cancer

Classical and atypical scrapie in sheep and goats: Review on the etiology, genetic factors, pathogenesis, diagnosis, and control measures of both diseases

Prion diseases, such as scrapie, are neurodegenerative diseases with a fatal outcome, caused by a conformational change of the cellular prion protein (PrPC), originating with the pathogenic form (PrPSc). Classical scrapie in small ruminants is the paradigm of prion diseases, as it was the first transmissible spongiform encephalopathy (TSE) described and is the most studied. It is necessary to understand the etiological properties, the relevance of the transmission pathways, the infectivity of the tissues, and how we can improve the detection of the prion protein to encourage detection of the disease. The aim of this review is to perform an overview of classical and atypical scrapie disease in sheep and goats, detailing those special issues of the disease, such as genetic fac-tors, diagnostic procedures, and surveillance approaches carried out in the European Union with the objective of controlling the dissemination of scrapie disease

Influence of pore size in protein G'-grafted mesoporous silica nanoparticles as a serum pretreatment system for in vitro allergy diagnosis

Particles with the capacity to bind to immunoglobulin G (IgG) can be used for the purification of IgG or to process clinical samples for diagnostic purposes. For in vitro allergy diagnosis, the high IgG levels in serum can interfere with the detection of allergen-specific IgE, the main diagnostic biomarker. Although commercially available, current materials present a low IgG capture capacity at large IgG concentrations or require complex protocols, preventing their use in the clinic. In this work, mesoporous silica nanoparticles are prepared with different pore sizes, to which IgG-binding protein G’ is grafted. It is found that for one particular optimal pore size, the IgG capture capacity of the material is greatly enhanced. The capacity of this material to efficiently capture human IgG in a selective way (compared to IgE) is demonstrated in both solutions of known IgG concentrations as well as in complex samples, like serum, from healthy controls and allergic patients using a simple and fast incubation protocol. Interestingly, IgG removal using the best-performing material enhances in vitro IgE detection in sera from patients allergic to amoxicillin. These results highlight the great translation potential of this strategy to the clinic in the context of in vitro allergy diagnosis.Funding for Open Access charge: Universidad de Málaga/CBUA. TEM experiments were performed in the ICTS “NANBIOSIS,” more specifically in the U28 Unit at IBIMA Plataforma BIONAND

Therapeutic targeting of HER2–CB2R heteromers in HER2-positive breast cancer

There is a subtype of breast cancer characterized by the overexpression of the oncogene HER2. Although most patients with this diagnosis benefit from HER2-targeted treatments, some do not respond to these therapies and others develop resistance with time. New tools are therefore warranted for the treatment of this patient population, and for early identification of those individuals at a higher risk of developing innate or acquired resistance to current treatments. Here, we show that HER2 forms heteromer complexes with the cannabinoid receptor CB2R, the expression of these structures correlates with poor patient prognosis, and their disruption promotes antitumor responses. Collectively, our results support HER2–CB2R heteromers as new therapeutic targets and prognostic tools in HER2+ breast cancer

Clinical and genetic characteristics in patients under 30 years with sporadic pituitary adenomas

[Objective] Pituitary adenomas (PA) are rare in young patients, and additional studies are needed to fully understand their pathogenesis in this population. We describe the clinical and genetic characteristics of apparently sporadic PA in a cohort of young patients.[Design] Clinical and molecular analysis of 235 patients (age ≤ 30 years) with PA. Clinicians from several Spanish and Chilean hospitals provided data.[Methods] Genetic screening was performed via next-generation sequencing and comparative genomic hybridization array. Clinical variables were compared among paediatric, adolescent (<19 years) and young adults’ (≥19–30 years) cohorts and types of adenomas. Phenotype–genotype associations were examined.[Results] Among the total cohort, mean age was 17.3 years. Local mass effect symptoms were present in 22.0%, and prolactinomas were the most frequent (44.7%). Disease-causing germline variants were identified in 22 individuals (9.3%), more exactly in 13.1 and 4.7% of the populations aged between 0–19 and 19–30 years, respectively; genetically positive patients were younger at diagnosis and had larger tumour size. Healthy family carriers were also identified.[Conclusions] Variants in genes associated with syndromic forms of PAs were detected in a large cohort of apparently sporadic pituitary tumours. We have identified novel variants in well-known genes and set the possibility of incomplete disease penetrance in carriers of MEN1 alterations or a limited clinical expression of the syndrome. Despite the low penetrance observed, screening of AIP and MEN1 variants in young patients and relatives is of clinical value.Peer reviewe

Longissimus dorsi transcriptome analysis of purebred and crossbred Iberian pigs differing in muscle characteristics

Background The two main genetic types in Iberian pig production show important phenotypic differences in growth, fattening and tissue composition since early developmental stages. The objective of this work was the evaluation of muscle transcriptome profile in piglets of both genetic types, in order to identify genes, pathways and regulatory factors responsible for their phenotypic differences. Contemporary families coming from pure Iberian pigs (IB) or from crossing with Duroc boars (DU×IB) were generated. Piglets (14 from each genetic type) were slaughtered at weaning (28 days) and longissimus dorsi was sampled for composition and gene expression studies. RNA was obtained and hybridized to Affymetrix Porcine Genechip expression arrays.Results Loin muscle chemical composition showed significant differences between genetic types in intramuscular fat content (6.1% vs. 4.3% in IB and DUxIB animals, respectively, P = 0.009) and in saturated (P = 0.019) and monounsaturated fatty acid proportions (P = 0.044). The statistical analysis of gene expression data allowed the identification of 256 differentially expressed (DE) genes between genetic types (FDR < 0.10), 102 upregulated in IB and 154 upregulated in DU×IB. Transcript differences were validated for a subset of DE genes by qPCR. We observed alteration in biological functions related to extracellular matrix function and organization, cellular adhesion, muscle growth, lipid metabolism and proteolysis. Candidate genes with known effects on muscle growth were found among the DE genes upregulated in DU×IB. Genes related to lipid metabolism and proteolysis were found among those upregulated in IB. Regulatory factors (RF) potentially involved in the expression differences were identified by calculating the regulatory impact factors. Twenty-nine RF were found, some of them with known relationship with tissue development (MSTN, SIX4, IRX3), adipogenesis (CEBPD, PPARGC1B), or extracellular matrix processes (MAX, MXI1). Correlation among the expression of these RF and DE genes show relevant differences between genetic types.Conclusion These results provide valuable information about genetic mechanisms determining the phenotypic differences on growth and meat quality between the genetic types studied, mainly related to the development and function of the extracellular matrix and also to some metabolic processes as proteolysis and lipid metabolism. Transcription factors and regulatory mechanisms are proposed for these altered biological functions. © 2014 Óvilo et al.; licensee BioMed Central Ltd