Las élites gobernantes priístas del Estado de México: su conformación y redes 1942-2005

El análisis que se realiza a lo largo de este texto tiene como objetivo explicar la conformación de las élites gubernamentales priístas en las sucesiones del ejecutivo local del Estado de México. Lo cual se pretende demostrar a través de una revisión teórica de las élites y desde la concepción del término; misma que para el caso de estudio se llevó a cabo mediante el reconocimiento de las redes de los principales actores políticos, lo que permite mostrar que sus relaciones de amistad, familiares o laborales son las que le posibilitan ascender y formar parte de las élites gubernamentales

Responsabilidad Social y Ciudadanía: Una perspectiva desde la universidad y la administración pública

La importancia de los estudios sobre ciudadanía se vincula con la imperiosa necesidad de fortalecer la democracia en todos aquellos espacios donde se manifiesta, principalmente en países como México, donde la falta de credibilidad en las instituciones democráticas ha permeado a la sociedad.Los desafíos contemporáneos requieren nuevos ajustes en diversos sentidos; al interior de las organizaciones es necesario adecuar los mecanismos con que interactúan frente a la sociedad en la que se desarrollan. Es requisito indispensable que el grueso de las organizaciones sociales se vinculen de manera directa con los problemas globales y nacionales: cambio climático, guerras, exigencias democráticas, movimientos sociales, pobreza, desempleo, inestabilidades políticas etc., ello les exige que se asuman como parte del complejo social, donde sus acciones repercuten de forma directa o indirecta

Adding 6 months of androgen deprivation therapy to postoperative radiotherapy for prostate cancer: a comparison of short-course versus no androgen deprivation therapy in the RADICALS-HD randomised controlled trial

Background Previous evidence indicates that adjuvant, short-course androgen deprivation therapy (ADT) improves metastasis-free survival when given with primary radiotherapy for intermediate-risk and high-risk localised prostate cancer. However, the value of ADT with postoperative radiotherapy after radical prostatectomy is unclear. Methods RADICALS-HD was an international randomised controlled trial to test the efficacy of ADT used in combination with postoperative radiotherapy for prostate cancer. Key eligibility criteria were indication for radiotherapy after radical prostatectomy for prostate cancer, prostate-specific antigen less than 5 ng/mL, absence of metastatic disease, and written consent. Participants were randomly assigned (1:1) to radiotherapy alone (no ADT) or radiotherapy with 6 months of ADT (short-course ADT), using monthly subcutaneous gonadotropin-releasing hormone analogue injections, daily oral bicalutamide monotherapy 150 mg, or monthly subcutaneous degarelix. Randomisation was done centrally through minimisation with a random element, stratified by Gleason score, positive margins, radiotherapy timing, planned radiotherapy schedule, and planned type of ADT, in a computerised system. The allocated treatment was not masked. The primary outcome measure was metastasis-free survival, defined as distant metastasis arising from prostate cancer or death from any cause. Standard survival analysis methods were used, accounting for randomisation stratification factors. The trial had 80% power with two-sided α of 5% to detect an absolute increase in 10-year metastasis-free survival from 80% to 86% (hazard ratio [HR] 0·67). Analyses followed the intention-to-treat principle. The trial is registered with the ISRCTN registry, ISRCTN40814031, and ClinicalTrials.gov, NCT00541047. Findings Between Nov 22, 2007, and June 29, 2015, 1480 patients (median age 66 years [IQR 61–69]) were randomly assigned to receive no ADT (n=737) or short-course ADT (n=743) in addition to postoperative radiotherapy at 121 centres in Canada, Denmark, Ireland, and the UK. With a median follow-up of 9·0 years (IQR 7·1–10·1), metastasis-free survival events were reported for 268 participants (142 in the no ADT group and 126 in the short-course ADT group; HR 0·886 [95% CI 0·688–1·140], p=0·35). 10-year metastasis-free survival was 79·2% (95% CI 75·4–82·5) in the no ADT group and 80·4% (76·6–83·6) in the short-course ADT group. Toxicity of grade 3 or higher was reported for 121 (17%) of 737 participants in the no ADT group and 100 (14%) of 743 in the short-course ADT group (p=0·15), with no treatment-related deaths. Interpretation Metastatic disease is uncommon following postoperative bed radiotherapy after radical prostatectomy. Adding 6 months of ADT to this radiotherapy did not improve metastasis-free survival compared with no ADT. These findings do not support the use of short-course ADT with postoperative radiotherapy in this patient population

Duration of androgen deprivation therapy with postoperative radiotherapy for prostate cancer: a comparison of long-course versus short-course androgen deprivation therapy in the RADICALS-HD randomised trial

Background Previous evidence supports androgen deprivation therapy (ADT) with primary radiotherapy as initial treatment for intermediate-risk and high-risk localised prostate cancer. However, the use and optimal duration of ADT with postoperative radiotherapy after radical prostatectomy remains uncertain. Methods RADICALS-HD was a randomised controlled trial of ADT duration within the RADICALS protocol. Here, we report on the comparison of short-course versus long-course ADT. Key eligibility criteria were indication for radiotherapy after previous radical prostatectomy for prostate cancer, prostate-specific antigen less than 5 ng/mL, absence of metastatic disease, and written consent. Participants were randomly assigned (1:1) to add 6 months of ADT (short-course ADT) or 24 months of ADT (long-course ADT) to radiotherapy, using subcutaneous gonadotrophin-releasing hormone analogue (monthly in the short-course ADT group and 3-monthly in the long-course ADT group), daily oral bicalutamide monotherapy 150 mg, or monthly subcutaneous degarelix. Randomisation was done centrally through minimisation with a random element, stratified by Gleason score, positive margins, radiotherapy timing, planned radiotherapy schedule, and planned type of ADT, in a computerised system. The allocated treatment was not masked. The primary outcome measure was metastasis-free survival, defined as metastasis arising from prostate cancer or death from any cause. The comparison had more than 80% power with two-sided α of 5% to detect an absolute increase in 10-year metastasis-free survival from 75% to 81% (hazard ratio [HR] 0·72). Standard time-to-event analyses were used. Analyses followed intention-to-treat principle. The trial is registered with the ISRCTN registry, ISRCTN40814031, and ClinicalTrials.gov , NCT00541047 . Findings Between Jan 30, 2008, and July 7, 2015, 1523 patients (median age 65 years, IQR 60–69) were randomly assigned to receive short-course ADT (n=761) or long-course ADT (n=762) in addition to postoperative radiotherapy at 138 centres in Canada, Denmark, Ireland, and the UK. With a median follow-up of 8·9 years (7·0–10·0), 313 metastasis-free survival events were reported overall (174 in the short-course ADT group and 139 in the long-course ADT group; HR 0·773 [95% CI 0·612–0·975]; p=0·029). 10-year metastasis-free survival was 71·9% (95% CI 67·6–75·7) in the short-course ADT group and 78·1% (74·2–81·5) in the long-course ADT group. Toxicity of grade 3 or higher was reported for 105 (14%) of 753 participants in the short-course ADT group and 142 (19%) of 757 participants in the long-course ADT group (p=0·025), with no treatment-related deaths. Interpretation Compared with adding 6 months of ADT, adding 24 months of ADT improved metastasis-free survival in people receiving postoperative radiotherapy. For individuals who can accept the additional duration of adverse effects, long-course ADT should be offered with postoperative radiotherapy. Funding Cancer Research UK, UK Research and Innovation (formerly Medical Research Council), and Canadian Cancer Society

Reducing the environmental impact of surgery on a global scale: systematic review and co-prioritization with healthcare workers in 132 countries

Abstract Background Healthcare cannot achieve net-zero carbon without addressing operating theatres. The aim of this study was to prioritize feasible interventions to reduce the environmental impact of operating theatres. Methods This study adopted a four-phase Delphi consensus co-prioritization methodology. In phase 1, a systematic review of published interventions and global consultation of perioperative healthcare professionals were used to longlist interventions. In phase 2, iterative thematic analysis consolidated comparable interventions into a shortlist. In phase 3, the shortlist was co-prioritized based on patient and clinician views on acceptability, feasibility, and safety. In phase 4, ranked lists of interventions were presented by their relevance to high-income countries and low–middle-income countries. Results In phase 1, 43 interventions were identified, which had low uptake in practice according to 3042 professionals globally. In phase 2, a shortlist of 15 intervention domains was generated. In phase 3, interventions were deemed acceptable for more than 90 per cent of patients except for reducing general anaesthesia (84 per cent) and re-sterilization of ‘single-use’ consumables (86 per cent). In phase 4, the top three shortlisted interventions for high-income countries were: introducing recycling; reducing use of anaesthetic gases; and appropriate clinical waste processing. In phase 4, the top three shortlisted interventions for low–middle-income countries were: introducing reusable surgical devices; reducing use of consumables; and reducing the use of general anaesthesia. Conclusion This is a step toward environmentally sustainable operating environments with actionable interventions applicable to both high– and low–middle–income countries

Cuidadanía corporativa como medio de discursos transnacionales : reflexiones desde el caso mexicano

En texto analiza aspectos éticos de la vida ciudadana en su acción y transformaciones ante el dominio económico limitante de la subjetividad política del ciudadano moderno. De este modo se explica cómo es que funciona el término ciudadanía y es empleado con una dimensión económica, de consumo e inclusive corporativa. En México, observa la autora, se plantean espacios comunes que mantienen una contradicción en los límites y funciones de esta ciudadanía, por lo que cuestiona el uso de este término por las corporaciones para su activismo en contra de la participacion activa y participativa ciudadana y, por ende, de la profundización de la vida política.Universidad Nacional Autónoma de México/Programa de Apoyo a Proyectos de Investigación e Innovación Tecnológica/"PAPIIT IN 400418"//[Los derechos humanos y los derechos del libre mercado frente a la crisis del Estado en América Latina]Capítulos de libr

Ciudad y ciudadanía: Hacia una resignificación desde el contexto mexicano

El capitalismo global atraviesa diferentes aristas de la vida social, trastocando la configuración de universos simbólicos, actores, dinámicas, espacios y prácticas sociales; tales reconfiguraciones tienden a asumir formas diversas y complejas ancladas a realidades concretas, aunque estrechamente vinculadas a los procesos globales contemporáneos.El presente trabajo construye el concepto de ciudadano y ciudadanía, partiendo de sus antecedentes históricos y de los principios y conceptos de las declaraciones liberales de fines del siglo xviii y del siglo xx. Asimismo, contribuye a la reflexión sobre el Estado democrático de derecho, realizando apuntamientos sobre su concepto y caracterización desde una perspectiva sociojurídica, para retomar al ciudadano y a la ciudadanía con el objetivo de identificar la forma y modos en los que se determinan y particularizan los derechos y obligaciones que se le imputan al ciudadano como parte integrante del Estado, así como para identificar y revisar los derechos fundamentales con los que el Estado caracteriza, diseña y particulariza su perfeccionamiento individual y su desarrollo colectivo

Pensamiento político y genealogía de la dignidad en América Latina

El libro contiene el desarrollo de preocupaciones estrechamente vinculadas, como son los conceptos de ciudadanía, democracia, derechos humanos e interculturaliad desde Latino-américa. El supuesto más importante que lo recorre, a pesar de los distintos enfoques que el lector podrá constatar, es el que sostiene la necesidad de ubicar los procesos propios del poder en nuestra región como condición para interpretar su relación con los pueblos originarios indígenas

Responsabilidad social universitaria

En un mundo globalizado, caracterizado por la incertidumbre, el individualismo y la competencia mercantil abierto, toda institución tiende a evaluase en función de los "productos" que ofrece el mercado y del costo-beneficio que su desarrollo conlleva. Lo anterior ha originado una serie de cuestionamientos hacia las instituciones universitarias con respecto a las funciones que históricamente les han sido asignadas y aquellas que han venido desempeñando en las últimas décadas. sin embargo las dudas y cuestionamientos, han girado principalmente en torno a los retos y transmutaciones que las universidades deben introducir en su actuar, para lograr adecuarse y sobrevivir a un mundo de cambio prácticamente instantáneo