Analytical Quantum Full-Wave Solutions for a 3D Circuit Quantum Electrodynamics System

High-fidelity general-purpose numerical methods are increasingly needed to improve superconducting circuit quantum information processor performance. One challenge in developing such numerical methods is the lack of reference data to validate them. To address this, we have designed a 3D system where all electromagnetic properties needed in a quantum analysis can be evaluated using analytical techniques from classical electromagnetic theory. Here, we review the basics of our field-based quantization method and then use these techniques to create the first-ever analytical quantum full-wave solution for a superconducting circuit quantum device. Specifically, we analyze a coaxial-fed 3D waveguide cavity with and without transmon quantum bits inside the cavity. We validate our analytical solutions by comparing them to numerical methods in evaluating single photon interference and computing key system parameters related to controlling quantum bits. In the future, our analytical solutions can be used to validate numerical methods, as well as build intuition about important quantum effects in realistic 3D devices.Comment: 14 pages, 11 figure

Production and characterization of lentivirus vector-based SARS-CoV-2 pseudoviruses with dual reporters: Evaluation of anti-SARS-CoV-2 viral effect of Korean Red Ginseng

Background: Pseudotyped virus systems that incorporate viral proteins have been widely employed for the rapid determination of the effectiveness and neutralizing activity of drug and vaccine candidates in biosafety level 2 facilities. We report an efficient method for producing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pseudovirus with dual luciferase and fluorescent protein reporters. Moreover, using the established method, we also aimed to investigate whether Korean Red Ginseng (KRG), a valuable Korean herbal medicine, can attenuate infectivity of the pseudotyped virus. Methods: A pseudovirus of SARS-CoV-2 (SARS-2pv) was constructed and efficiently produced using lentivirus vector systems available in the public domain by the introduction of critical mutations in the cytoplasmic tail of the spike protein. KRG extract was dose-dependently treated to Calu-3 cells during SARS2-pv treatment to evaluate the protective activity against SARS-CoV-2. Results: The use of Calu-3 cells or the expression of angiotensin-converting enzyme 2 (ACE2) in HEK293T cells enabled SARS-2pv infection of host cells. Coexpression of transmembrane protease serine subtype 2 (TMPRSS2), which is the activator of spike protein, with ACE2 dramatically elevated luciferase activity, confirming the importance of the TMPRSS2-mediated pathway during SARS-CoV-2 entry. Our pseudovirus assay also revealed that KRG elicited resistance to SARS-CoV-2 infection in lung cells, suggesting its beneficial health effect. Conclusion: The method demonstrated the production of SARS-2pv for the analysis of vaccine or drug candidates. When KRG was assessed by the method, it protected host cells from coronavirus infection. Further studies will be followed for demonstrating this potential benefit

Development of Play for Peace Website (semester?), IPRO 328: Play for Peace IPRO 328 Midterm Report Sp06

At this point, most of the requirements from the client have been obtained (in table below). Based off of this, we have selected the Joomla Client Management System to develop the web-site. The decision was made between Joomla, Mambo, and PHP-Nuke. All three are CMS systems with varying capabilities and weaknesses. The description for each of the CMS systems is provided below. What is left is to continue getting feedback from the client as well as continuing to adapt and modify Joomla as needed to fit our needs.Deliverables for IPRO 328: Development of Play for Peace Website for the Spring 2006 semester

Development of Play for Peace Website (semester?), IPRO 328: Play for Peace IPRO 328 IPRO Day Presentation Sp06

At this point, most of the requirements from the client have been obtained (in table below). Based off of this, we have selected the Joomla Client Management System to develop the web-site. The decision was made between Joomla, Mambo, and PHP-Nuke. All three are CMS systems with varying capabilities and weaknesses. The description for each of the CMS systems is provided below. What is left is to continue getting feedback from the client as well as continuing to adapt and modify Joomla as needed to fit our needs.Deliverables for IPRO 328: Development of Play for Peace Website for the Spring 2006 semester

Development of Play for Peace Website (semester?), IPRO 328

At this point, most of the requirements from the client have been obtained (in table below). Based off of this, we have selected the Joomla Client Management System to develop the web-site. The decision was made between Joomla, Mambo, and PHP-Nuke. All three are CMS systems with varying capabilities and weaknesses. The description for each of the CMS systems is provided below. What is left is to continue getting feedback from the client as well as continuing to adapt and modify Joomla as needed to fit our needs.Deliverables for IPRO 328: Development of Play for Peace Website for the Spring 2006 semester

Development of Play for Peace Website (semester?), IPRO 328: Play for Peace IPRO 328 Poster Sp06

At this point, most of the requirements from the client have been obtained (in table below). Based off of this, we have selected the Joomla Client Management System to develop the web-site. The decision was made between Joomla, Mambo, and PHP-Nuke. All three are CMS systems with varying capabilities and weaknesses. The description for each of the CMS systems is provided below. What is left is to continue getting feedback from the client as well as continuing to adapt and modify Joomla as needed to fit our needs.Deliverables for IPRO 328: Development of Play for Peace Website for the Spring 2006 semester

Development of Play for Peace Website (semester?), IPRO 328: Play for Peace IPRO 328 Project Plan Sp06

At this point, most of the requirements from the client have been obtained (in table below). Based off of this, we have selected the Joomla Client Management System to develop the web-site. The decision was made between Joomla, Mambo, and PHP-Nuke. All three are CMS systems with varying capabilities and weaknesses. The description for each of the CMS systems is provided below. What is left is to continue getting feedback from the client as well as continuing to adapt and modify Joomla as needed to fit our needs.Deliverables for IPRO 328: Development of Play for Peace Website for the Spring 2006 semester

Protective Effect of Ciclopirox against Ovariectomy-Induced Bone Loss in Mice by Suppressing Osteoclast Formation and Function

Postmenopausal osteoporosis is closely associated with excessive osteoclast formation and function, resulting in the loss of bone mass. Osteoclast-targeting agents have been developed to manage this disease. We examined the effects of ciclopirox on osteoclast differentiation and bone resorption in vitro and in vivo. Ciclopirox significantly inhibited osteoclast formation from primary murine bone marrow macrophages (BMMs) in response to receptor activator of nuclear factor kappa B ligand (RANKL), and the expression of genes associated with osteoclastogenesis and function was decreased. The formation of actin rings and resorption pits was suppressed by ciclopirox. Analysis of RANKL-mediated early signaling events in BMMs revealed that ciclopirox attenuates IκBα phosphorylation without affecting mitogen-activated protein kinase activation. Furthermore, the administration of ciclopirox suppressed osteoclast formation and bone loss in ovariectomy-induced osteoporosis in mice and reduced serum levels of osteocalcin and C-terminal telopeptide fragment of type I collagen C-terminus. These results indicate that ciclopirox exhibits antiosteoclastogenic activity both in vitro and in vivo and represents a new candidate compound for protection against osteoporosis and other osteoclast-related bone diseases

Development of Play for Peace Website (semester?), IPRO 328: Play for Peace IPRO 328 Final Report Sp06

At this point, most of the requirements from the client have been obtained (in table below). Based off of this, we have selected the Joomla Client Management System to develop the web-site. The decision was made between Joomla, Mambo, and PHP-Nuke. All three are CMS systems with varying capabilities and weaknesses. The description for each of the CMS systems is provided below. What is left is to continue getting feedback from the client as well as continuing to adapt and modify Joomla as needed to fit our needs.Deliverables for IPRO 328: Development of Play for Peace Website for the Spring 2006 semester