Cost-effectiveness modelling of three different hysterosalpingography diagnostic strategies in addition to standard fertility management for couples with unexplained infertility in the United Kingdom

Funding: This research was supported by Guerbet, Paris, France. Guerbet had no influence on the results of this researchPeer reviewedPostprin

Effectiveness of antenatal corticosteroids at term:Can we trust the data that 'inform' us?

Randomized controlled trials (RCTs) are a cornerstone for the assessment of the effectiveness of interventions. Appropriate randomization, design, sample size, statistical analyses, and conduct that reduces the risk of bias, enhance the chance they will deliver true research findings. The credibility of RCTs is difficult to assess without objective evidence of compliance with Good Clinical Practice standards. Remarkably, no mechanisms are in place both in the initial peer review process and during meta-analysis to assess these, and little guidance on how to assess data where research integrity cannot be confirmed (e.g. where data originated from a setting without established infrastructure or an era preceding current standards). We describe the case of the use of antenatal steroids. When these drugs are used in early preterm birth, their benefits outweigh the harms. However, later in pregnancy, and specifically at term, this balance is less clear. We describe that the four randomised clinical trials that inform clinical practice through the Cochrane meta-analysis, for various reasons, lack clear governance which makes it difficult to verify provenance and reliability of the data. We conclude that transparency and assessment of data credibility need to be inbuilt both at the time of publication and at the time of meta-analysis. This will drive up standards and encourage appropriate interpretation of results and the context from which they were derived.Ben W.Mol, Wentao Li, Shimona Lai, Sarah Stoc

The changing temporal association between caesarean birth and neonatal death in Ethiopia : Secondary analysis of nationally representative surveys

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Statistical significance and publication reporting bias in abstracts of reproductive medicine studies

Funding Information: We thank Dr David Chavalarias from Complex Systems Institute of Paris Ile-de-France for sharing scripts in extracting P-values. B.W.M. is supported by an National Health and Medical Research Council (NHMRC) Investigator grant (GNT1176437); B.W.M. reports consultancy, research grants, and travel support from Merck. W.L. is supported by an NHMRC Investigator Grant (GNT2016729). Q.F. reports receiving a PhD scholarship from Merck. The other author has no conflict of interest to declare. Funding Information: B.W.M. is supported by an National Health and Medical Research Council (NHMRC) Investigator grant (GNT1176437); B.W.M. reports consultancy, research grants, and travel support from Merck. W.L. is supported by an NHMRC Investigator Grant (GNT2016729). Q.F. reports receiving a PhD scholarship from Merck. The other author has no conflict of interest to declare. Publisher Copyright: © 2024 Oxford University Press. All rights reserved.Peer reviewe

The impact of body mass index on labour management and mode of delivery : A retrospective matched cohort study

FUNDINGBWM is supported by an NHMRC Investigator grant (GNT1176437). BWM reports consultancy, research funding and travel support from Merck.ACKNOWLEDGEMENTSOpen access publishing facilitated by Monash University, as part of the Wiley - Monash University agreement via the Council of Australian University Librarians.Peer reviewedPublisher PD

Seasonal variability does not impact in vitro fertilization success

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Diagnosis or prognosis? : An umbrella review of mid-trimester cervical length and spontaneous preterm birth

Funding Information: This work is funded by an Australian National Health and Medical Research Council project grant (GNT1146590). The funder was not involved in conducting research or writing the paper. Funding Information: BWM is supported by an NHMRC Practitioner Fellowship (GNT1082548) and reports a consultancy for ObsEva, Merck Merck KGaA, and Guerbet. Completed disclosure of interests form available to view online as supporting information. Funding Information: An earlier, abbreviated form of this manuscript was presented as a virtual free communication at the Royal Australian and New Zealand College of Obstetricians and Gynaecologists’ Annual Scientific Meeting 2021 (Monday 15 February, online-only event). Open access publishing facilitated by Monash University, as part of the Wiley - Monash University agreement via the Council of Australian University Librarians. Publisher Copyright: © 2023 The Authors. BJOG: An International Journal of Obstetrics and Gynaecology published by John Wiley & Sons Ltd.Peer reviewedPublisher PD

FIGO good practice recommendations on delayed umbilical cord clamping

Funding Information: Ana Bianchi reports no conflicts of interest. Ben W. Mol reports an investigator grant from NHMRC; consultancy for ObsEva; and research funding from Guerbet, Ferring, and Merck KGaA. Bo Jacobbson reports research grants from Swedish Research Council, Norwegian Research Council, March of Dimes, Burroughs Wellcome Fund, and the US National Institute of Health; clinical diagnostic trials on NIPT with Ariosa (completed), Natera (ongoing), Vanadis (completed), and Hologic (ongoing) with expenditures reimbursed per patient; clinical probiotic studies with product provided by FukoPharma (ongoing, no funding), and BioGaia (ongoing; also provided a research grant for the specific study); collaboration in IMPACT study where Roche, Perkin Elmer, and Thermo Fisher provided reagents to PLGF analyses; coordination of scientific conferences and meetings with commercial partners such as NNFM 2015, ESPBC 2016, and a Nordic educational meeting about NIPT and pre‐eclampsia screening. Bo Jacobbson is also Chair of the FIGO Working Group for Preterm Birth and the European Association of Perinatal Medicine special interest group on preterm delivery; steering group member of Genomic Medicine Sweden; chairs the Genomic Medicine Sweden complex diseases group; and is Swedish representative in the Nordic Society of Precision Medicine.Peer reviewedPublisher PD

FIGO good practice recommendations on modifiable causes of iatrogenic preterm birth

Funding Information: Catalina M. Valencia reports no conflicts of interest. Ben W. Mol reports an investigator grant from NHMRC; consultancy for ObsEva; and research funding from Guerbet, Ferring, and Merck KGaA. Bo Jacobbson reports research grants from Swedish Research Council, Norwegian Research Council, March of Dimes, Burroughs Wellcome Fund and the US National Institute of Health; clinical diagnostic trials on NIPT with Ariosa (completed), Natera (ongoing), Vanadis (completed) and Hologic (ongoing) with expendidures reimbused per patient; clinical probiotic studies with product provided by FukoPharma (ongoing, no funding) and BioGaia (ongoing; also provided a research grant for the specific study); collaboration in IMPACT study where Roche, Perkin Elmer and Thermo Fisher provided reagents to PLGF analyses; coordination of scientific conferences and meetings with commercial partners as such as NNFM 2015, ESPBC 2016 and a Nordic educational meeting about NIPT and preeclampsia screening. Bo Jacobbson is also Chair of the FIGO Working Group for Preterm Birth and the European Association of Perinatal Medicine's special interest group of preterm delivery; steering group member of Genomic Medicine Sweden; chairs the Genomic Medicine Sweden complex diseases group; and is Swedish representative in the Nordic Society of Precision Medicine.Peer reviewedPublisher PD