Genetic determinants of premature menopause in A Mashhad population cohort

Funding Information: This work was supported by a grant from the Vice Chancellor for Research at Mashhad University of Medical Sciences and this was a part of the Ph.D. student dissertation (no. 971084). The authors have no conflict of interest to disclose.Peer reviewedPublisher PD

INVESTIGATION OF DESIGN CODES RELIABILITY FOR SEISMIC DESIGN OF STEEL PLATE SHEAR WALLS CONSISTING OF SEVERAL PARAMETERS

Steel plate shear walls have been used as lateral resistant systems at several buildings particularly at high rise building during past three decades. This system contains appropriate rigidity to control displacements and also have ductile failure and high energy dissipation mechanism, so it can be used for new buildings or strengthening existing structures at seismic prone areas. Generally steel plate shear walls are consisting of steel plate walls and two boundary columns and horizontal floor beams. In this paper, initially a steel plate shear wall of a 5-floor building at high seismic area was designed according to AISC 341-05, then ABAQUS finite element program was used to investigate the seismic behavior of structure and get hysteresis curves under cyclic loading and also investigate the several parameter effects on local instability and non-linearity of material at designed typical shear wall and also the other new walls with different opens and rigidities. Numerical analysis results indicate that rigidity, shear capacity, and energy dissipation of wall were increased whenever column dimensions and length to height ratio was increased. Moreover, the main failure mode as global buckling was happened at the base of the column with increasing of the number of floors, so indicating the decreasing capacity and rigidity. And also the results showed that more open dimensions caused the higher ductility, decreasing capacity and rigidity and dissipation. The higher capacity, rigidity, energy dissipation, and ductility were observed at shear wall consisting of the more stiff nesses

Effects of Combining Medication and Pivotal Response Treatment on Aberrant Behavior in Children with Autism Spectrum Disorder

Abstract: The purpose of this study was to investigate the effects of combined risperidone (RIS) and pivotal response treatment (PRT) on children with autism spectrum disorder (ASD). A total of 34 children diagnosed with ASD according to the Diagnostic and Statistical Manual of Mental Disorders, fifth edition (DSM-V) (mean age of 12.36 years) were randomly assigned to either of two groups; the first group (n = 17) received combined PRT–RIS while the second group (n = 17) received RIS only. Behavioral problems were evaluated with the Aberrant Behavior Checklist (ABC), whereas global improvement (GI) was measured with the Clinical Global Impressions (CGI). Assessment of ABC was performed before intervention, after intervention (12 weeks), and following 3 months of the intervention (follow-up). Total ABC scores were seen to decrease in both groups after 3 months, as compared with the scores prior to the interventions. Also, in both groups, mean scores of behavioral problems after the intervention were not significantly different from those prior to the intervention, in all subscales but the inappropriate speech (p < 0.001). However, both groups showed significant differences in mean scores of ABC subscales in both of the post-intervention evaluation stages. It was concluded that the combination of behavioral and drug interventions can further improve behavioral problems, ultimately improving patient’s communication and social skills

The effect of climate and weather on the epidemiology of leishmaniasis in the city of Yazd (an ecological study)

Introduction: Leishmaniasis is a major health problem in Iran and it has a heavy economic burden on communities. Therefore, the aim of this study is to investigate the effects of climate on the prevalence and incidence of leishmaniasis in Yazd. Methods: This is an ecological study. Data was collected from health department of Yazd University of Medical Sciences during the years 2003-2007 by age and sex, monthly and information about climate factors on monthly and annual basis including temperature, Relative humidity of air, precipitation from the general weather office of Yazd city, the information was entered into SPSS 16 software and analyzed by descriptive statistics as well as Spearman correlation and time delay analysis and analyzed the relationship and correlation between the elements of the cluster and the occurrence Cutaneous Leishmaniasis was performed in Yazd city. Resultus: According to the findings of this study, the most reported cases of leishmaniasis in men aged 11 to 30 years with 561 (69.9%), and in women in the age group of 71 and over with 41 The case (66.1%) and the highest upward trend were 2004 to 2005, 2009 to 2012, and in the month of October. Conclusion: The results of this study indicate that there is a strong and positive relationship with relative humidity and precipitation, which can guide policymakers in the area of health policy in this province to control and more effective prevention measures

Comparison of the hypothetical 57 Co brachytherapy source with the 192 Ir source

Aim of the study : The 57 Co radioisotope has recently been proposed as a hypothetical brachytherapy source due to its high specific activity, appropriate half-life (272 days) and medium energy photons (114.17 keV on average). In this study, Task Group No. 43 dosimetric parameters were calculated and reported for a hypothetical 57 Co source. Material and methods : A hypothetical 57 Co source was simulated in MCNPX, consisting of an active cylinder with 3.5 mm length and 0.6 mm radius encapsulated in a stainless steel capsule. Three photon energies were utilized (136 keV [10.68%], 122 keV [85.60%], 14 keV [9.16%]) for the 57 Co source. Air kerma strength, dose rate constant, radial dose function, anisotropy function, and isodose curves for the source were calculated and compared to the corresponding data for a 192 Ir source. Results : The results are presented as tables and figures. Air kerma strength per 1 mCi activity for the 57 Co source was 0.46 cGyh–1 cm 2 mCi–1. The dose rate constant for the 57 Co source was determined to be 1.215 cGyh–1U–1. The radial dose function for the 57 Co source has an increasing trend due to multiple scattering of low energy photons. The anisotropy function for the 57 Co source at various distances from the source is more isotropic than the 192 Ir source. Conclusions : The 57 Co source has advantages over 192 Ir due to its lower energy photons, longer half-life, higher dose rate constant and more isotropic anisotropic function. However, the 192 Ir source has a higher initial air kerma strength and more uniform radial dose function. These properties make 57 Co a suitable source for use in brachytherapy applications