Pathology reporting in neuroendocrine neoplasms of the digestive system: everything you always wanted to know but were too afraid to ask

During the 5th NIKE (Neuroendocrine tumors Innovation in Knowledge and Education) meeting, held in Naples, Italy, in May 2019, discussions centered on the understanding of pathology reports of gastroenetropancreactic neuroendocrine neoplasms. In particular, the main problem concerned the difficulty that clinicians experience in extrapolating relevant information from neuroendocrine tumor pathology reports. During the meeting, participants were asked to identify and rate issues which they have encountered, for which the input of an expert pathologist would have been appreciated. This article is a collection of the most rated questions and relative answers, focusing on three main topics: 1) morphology and classification; 2) Ki67 and grading; 3) immunohistochemistry. Patient management should be based on multidisciplinary decisions, taking into account clinical and pathology-related features with clear comprehension between all health care professionals. Indeed, pathologists require clinical details and laboratory findings when relevant, while clinicians require concise and standardized reports. In keeping with this last statement, the minimum requirements in pathology datasets are provided in this paper and should be a baseline for all neuroendocrine tumor professionals

Commentary: Case Report: Abdominal Lymph Node Metastases of Parathyroid Carcinoma: Diagnostic Workup, Molecular Diagnosis, and Clinical Management

In the issue of March 2021, Lenschow et al. reported the case of a 46-year-old woman with recurrent, programmed death-ligand-1 (PD-L1) negative, tumor mutational burden (TMB)-high parathyroid carcinoma (PC), who showed stable disease as her best response on imaging, and a three-fold drop in PTH after treatment with intravenous pembrolizumab. Given the remarkable results obtained by Lenschow et al. with the anti-PD-1 agent pembrolizumab in the above-mentioned case, we performed an extensive search for possible further relevant data sources, including a) full published articles in international online databases (PubMed, Web of Science, Scopus, and Embase); b) preliminary reports in selected international meeting abstract repositories (American Society of Clinical Oncology, ASCO; European Neuroendocrine Tumor Society, ENET; European Society for Medical Oncology, ESMO); c) registered clinical trials in the U.S. National Institutes of Health registry of clinical trials (http://clinicaltrials.gov) and in any primary register of the WHO International Clinical Trials Registry Platform (ICTRP)

Rettorragia severa dopo biopsia prostatica transrettale ecoguidata. Case report

Caso clinico. Gli autori riportano un caso di rettorragia severa in seguito a biopsia prostatica transrettale ecoguidata (BPTE). Intervento. Dopo aver posto la diagnosi, il paziente è stato sottoposto a trattamento endoscopico risolutivo (fallimento delle manovre meccaniche di emostasi, colonscopia in urgenza, emostasi mediante soluzione adrenalinata, coagulazione bipolare e Argon Plasma Coagulation). Risultati. Guarigione completa. Follow-up ad 1 anno negativo. Conclusioni. Il sanguinamento emodinamicamente significativo post-BPTE costituisce una entità nosologica importante, che può mettere a rischio la vita del paziente. La maggiore conoscenza dei fattori di rischio e delle cause ne potrà in futuro limitare l?incidenza. La BPTE resta comunque senza dubbio la migliore procedura per lo screening del tumore della prostata nella popolazione generale, sempre in associazione al dosaggio del PSA

Halaesa Archonidea. Lo scavo del settore nord-est delle fortificazioni. Risultati preliminari

This report describes the activities and results of two years of archaeological excavations carried out by the University of Palermo at the site of Halaesa. The excavations revealed the structure of the ancient city walls (maybe built in two different phases, during the Late Hellenistic / Early Roman period) and the presence of a tank close to the wall, connected to the defense system

Towards a Visual Query Interface for Phylogenetic Databases

Querying and visualization of phylogenetic databases remain a great challenge due to their complex tree type semi structured nature. Naturally, successful phylogenetic databases such as the ‘I & of Life database at the University of Arizona are implemented as Web documents in HTML. While Web implementation of such databases facilitate the representation, and in part, visualization of their contents, querying remains an issue. The interoperability of Web-based phylogenetic databases with other similar databases such as TreeBase and RDB which are implemented using traditional database management systems, has not been possible due to the impedance mismatch between the underlying query and data representation framework. In this paper, we present a novel approach to phylogentic database management using existing database technologies without compromising potential opportunities for visualization and interoperability. We present a Web-based tool for the creation, querying and visualization of phylogenetic databases. We demonstrate the functional capabilities and strengths of our system by recreating the Dee of LZje database in our system and performing queries that are not possible in the original Tree of Life database. Keywords Phylogenies, tree and semi structured data, visualization, query language, information retrieval, relational database, web 1