Combined effects of lipoprotein lipase and apolipoprotein E polymorphisms on serum lipid levels in Serbian population

Lipoprotein lipase (LPL) gene mutations might be one of genetic factors for the development of hyperlipoproteinemia in apoE2/2 homozygotes and E2 heterozygotes. Fasting serum lipids and analyses of the LPL gene Asn291Ser polymorphism and apolipoprotein (apo) E common polymorphism were performed in 201 healthy subjects. An interaction between the LPL/apoE DNA polymorphisms on serum total cholesterol (TC) and triglycerides (TG) variation was found. Individuals carrying the E2+/Ser291 allele had significantly higher mean TC (P LT 0.01) and TG (P LT 0.05) and lower high density lipoprotein cholesterol (HDLC) (P LT 0.05) compared with E2+/ Asn291. The results of this study demonstrate relationship between LPL and apoE DNA polymorphism. and serum lipid levels.EUROMEDLAB 2003: 15th IFCC/FESCC European Congress of Clinical Chemistry and Laboratory Medicine, Proceedings, Jun 01-05, 2003, Barcelona, Spai

Endothelial NOS G894T and MMP-3 5A/6A gene polymorphisms and hypertension in Serbian population

The incidence of hypertension is increasing and it is more common in man than in women. Up to date, MMP-3 5A/6A polymorphism has been associated with artery stiffening and elevated blood pressure, whereas results considering association of endothelial NOS (eNOS) G894T polymorphism with hypertension are controversial. The aim of our study was to analyze the possible association of eNOS G894T and MMP-3 5A/6A gene polymorphisms with hypertension in Serbian population. Study sample consisted of 172 hypertensive and 200 normotensive subjects divided by gender. Both female and male group was truncated according to age. All subjects were genotyped for MMP-3 5A/6A and eNOS G894T polymorphism. There was a significantly higher (P LT 0.05) prevalence of 5A/5A genotype in hypertensive females compared to normotensive ones (19.30% vs. 10.84%) even more pronounced in group GT = 50 years, according to its recessive effect. In young males ( LT 40 years), we found 3.7-fold increased risk for hypertension associated with allele 6A (P LT 0.01), and 8.1-fold with genotype 6A/6A (P=0.01) according to recessive model. We found no association of eNOS G894T polymorphism with hypertension. These results indicate that there were gender-and age-specific differences in association of MMP-3 5A/6A polymorphism with hyperin Serbian population

Association of ACE I/D and MMP-3 5A/6A gene polymorphisms with hypertension in men from Serbia

The ACE and MMP-3 loci are involved in the vascular remodeling, increased intima media thickness and arterial stiffness associated with hypertension. We determined ACE I/D and MMP-3 5A/6A gene polymorphisms in 231 Caucasian males (126/105, hypertensive/normotensive). Owing to age-related differences hypertension, the sample was truncated with respect to age (the cut-off point was the age of 40). Our results indicate that ACE I/D and MMP-3 5A/6A polymorphisms are likely to be risk factors for hypertension in men from Serbia = 40 years of age. In the same group, the combined effect of DD/6A+ genotypes on hypertension was more pronounced than their separate effect.

ACE I/D and MMP-3 5A/6A gene polymorphisms and hypertension in Serbian males

76th Congress of the European-Atherosclerosis-Society, Jun 10-13, 2007, Helsinki, Finlan

Association of MMP-3 5A/6A and NOS3 G894T polymorphisms with hypertension and serum hdl cholesterol level

75th Congress of the European-Atherosclerosis-Society, Apr 23-26, 2005, Prague, Czech Republi