Meta-analysis of 49 549 individuals imputed with the 1000 Genomes Project reveals an exonic damaging variant in ANGPTL4 determining fasting TG levels

Background So far, more than 170 loci have been associated with circulating lipid levels through genomewide association studies (GWAS). These associations are largely driven by common variants, their function is often not known, and many are likely to be markers for the causal variants. In this study we aimed to identify more new rare and low-frequency functional variants associated with circulating lipid levels. Methods We used the 1000 Genomes Project as a reference panel for the imputations of GWAS data from ~60 000 individuals in the discovery stage and ~90 000 samples in the replication stage. Results Our study resu

Computer assisted identification of metabolite mass spectra: How can quantum mechanics help?

info:eu-repo/semantics/nonPublishe

Computer assisted identification of metabolite mass spectra: How can machine learning and quantum mechanics help?

info:eu-repo/semantics/nonPublishe

Machine learning-driven validation platform for mass spectrometry imaging using tandem mass spectra and chemical structure databases

info:eu-repo/semantics/nonPublishe