LA MEZCLA DE CÓDIGOS: LOS PROCESOS EN LAS REVISTAS PARA MUJERES DE MÉXICO

Hasta la fecha, se han hecho muchos estudios sobre la mezcla de códigos en el discurso oral, aunque es lo contrario para el mismo fenómeno en el discurso escrito. El trabajo presente presenta una investigación de corte cualitativo, por medio del uso de un corpus, acerca de la mezcla de códigos en cuatro revistas para mujeres en español, publicadas en México. El objetivo de la investigación es encontrar y categorizar las ocurrencias encontradas según los procesos de inserción, alternancia y lexicalización congruente, sugeridos por Muysken (2000). Los resultados del estudio muestran que el fenómeno de la mezcla de códigos en el discurso escrito en México sólo involucra un sólo proceso, la inserción y que el fenómeno ocurre en todas las revistas analizadas que tiene una amplia gama de lectores

PDGFB as a vascular normalization agent in an ovarian cancer model treated with a gamma-secretase inhibitor

Ovarian cancer is the fifth leading cause of cancer-related deaths in women. In the past 20 years, the canonical types of drugs used to treat ovarian cancer have not been replaced and the survival rates have not changed. These facts show the clear need to find new therapeutic strategies for this illness. Thus, the aim of the present study was to investigate the effect of a gamma-secretase inhibitor (DAPT) in combination with the Platelet-derived growth factor B (PDGFB) on an ovarian cancer xenograft model. To achieve this goal, we analyzed the effect of the administration of DAPT alone and the co-administration of DAPT and recombinant PDGFB on parameters associated with tumour growth and angiogenesis in an orthotopic experimental model of ovarian cancer. We observed that the dose of DAPT used was ineffective to reduce ovarian tumour growth, but showed anticancer activity when co-administered with recombinant PDGFB. The administration of PDGFB alone normalized tumour vasculature by increasing periendothelial coverage and vascular functionality. Interestingly, this effect exerted by PDGFB was also observed in the presence of DAPT. Our findings suggest that PDGFB is able to improve tumor vascularity and allows the anticancer action of DAPT in the tumor. We propose that this therapeutic strategy could be a new tool for ovarian cancer treatment and deserves further studies.Fil: Pazos Maidana, María Camila. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Sequeira, Gonzalo Ricardo. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Bocchicchio, Sebastian. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: May, Maria. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Farmacológicas. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Investigaciones Farmacológicas; ArgentinaFil: Abramovich, Dalhia Nurit. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Parborell, Maria Fernanda Agustina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Tesone, Marta. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Irusta, Griselda. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentin

Phase behavior and rheological analysis of reverse liquid crystals and W/I2, W/H2 gel emulsions using an amphiphilic block copolymer.

This article reports the phase behavior determi- nation of a system forming reverse liquid crystals and the formation of novel disperse systems in the two-phase region. The studied system is formed by water, cyclohexane, and Pluronic L-121, an amphiphilic block copolymer considered of special interest due to its aggregation and structural proper- ties. This system forms reverse cubic (I2) and reverse hexagonal (H2) phases at high polymer concentrations. These reverse phases are of particular interest since in the two-phase region, stable high internal phase reverse emulsions can be formed. The characterization of the I2 and H2 phases and of the derived gel emulsions was performed with small-angle X-ray scattering (SAXS) and rheometry, and the influence of temperature and water content was studied. TheH2 phase experimented a thermal transition to an I2 phase when temperature was increased, which presented an Fd3m structure. All samples showed a strong shear thinning behavior from low shear rates. The elasticmodulus (G0) in the I2 phase was around 1 order of magnitude higher than in theH2 phase. G0 was predominantly higher than the viscousmodulus (G00). In the gel emulsions,G0 was nearly frequency-independent, indicating their gel type nature. Contrarily to water-in-oil (W/O) normal emulsions, in W/I2 and W/H2 gel emulsions, G0, the complex viscosity (|η*|), and the yield stress (τ0) decreased with increasing water content, since the highly viscous microstructure of the con- tinuous phase was responsible for the high viscosity and elastic behavior of the emulsions, instead of the volumefraction of dispersed phase and droplet size. A rheological analysis, in which the cooperative flow theory, the soft glass rheology model, and the slip plane model were analyzed and compared, was performed to obtain one single model that could describe the non-Maxwellian behavior of both reverse phases and highly concentrated emulsions and to characterize their microstructure with the rheological properties

AKT1 and AKT2 isoforms play distinct roles during breast cancer progression through the regulation of specific downstream proteins

The purpose of this study was to elucidate the mechanisms associated with the specific effects of AKT1 and AKT2 isoforms in breast cancer progression. We modulated the abundance of specific AKT isoforms in IBH-6 and T47D human breast cancer cell lines and showed that AKT1 promoted cell proliferation, through S6 and cyclin D1 upregulation, but it inhibited cell migration and invasion through β1-integrin and focal adhesion kinase (FAK) downregulation. In contrast, AKT2 promoted cell migration and invasion through F-actin and vimentin induction. Thus, while overexpression of AKT1 promoted local tumor growth, downregulation of AKT1 or overexpression of AKT2 promoted peritumoral invasion and lung metastasis. Furthermore, we evaluated The Cancer Genome Atlas (TCGA) dataset for invasive breast carcinomas and found that increased AKT2 but not AKT1 mRNA levels correlated with a worse clinical outcome. We conclude that AKT isoforms play specific roles in different steps of breast cancer progression, with AKT1 involved in the local tumor growth and AKT2 involved in the distant tumor dissemination, having AKT2 a poorer prognostic value and consequently being a worthwhile target for therapy.Facultad de Ciencias Naturales y MuseoCentro de Investigaciones Inmunológicas Básicas y Aplicada

AKT1 and AKT2 isoforms play distinct roles during breast cancer progression through the regulation of specific downstream proteins

The purpose of this study was to elucidate the mechanisms associated with the specific effects of AKT1 and AKT2 isoforms in breast cancer progression. We modulated the abundance of specific AKT isoforms in IBH-6 and T47D human breast cancer cell lines and showed that AKT1 promoted cell proliferation, through S6 and cyclin D1 upregulation, but it inhibited cell migration and invasion through β1-integrin and focal adhesion kinase (FAK) downregulation. In contrast, AKT2 promoted cell migration and invasion through F-actin and vimentin induction. Thus, while overexpression of AKT1 promoted local tumor growth, downregulation of AKT1 or overexpression of AKT2 promoted peritumoral invasion and lung metastasis. Furthermore, we evaluated The Cancer Genome Atlas (TCGA) dataset for invasive breast carcinomas and found that increased AKT2 but not AKT1 mRNA levels correlated with a worse clinical outcome. We conclude that AKT isoforms play specific roles in different steps of breast cancer progression, with AKT1 involved in the local tumor growth and AKT2 involved in the distant tumor dissemination, having AKT2 a poorer prognostic value and consequently being a worthwhile target for therapy.Facultad de Ciencias Naturales y MuseoCentro de Investigaciones Inmunológicas Básicas y Aplicada

Estrategia comunicacional de la UPID Semillas Hortícolas Locales: articulando saberes, potenciando espacios

Se trata de una tesis de grado, para alcanzar el título de Ingeniera Agrónoma. El trabajo final de carrera se enmarca dentro de las actividades desarrolladas desde la “UPID Semillas Hortícolas Locales del Cinturón Verde Platense”, unidad promocional de investigación y desarrollo perteneciente a la Facultad de Cs. Agrarias y Forestales. La actividad central de la UPID implica la revalorización, multiplicación y difusión de las semillas de distintas hortalizas típicas del gran La Plata. En base a información recabada en torno a las Hortalizas Típicas Locales –HTL- y al mundo cultural de los productores, así como de otros interlocutores, y -teniendo en cuenta distintas herramientas metodológicas- se ha llegado a conformar una estrategia comunicacional que aportará al cumplimiento de los objetivos de la UPID. Este trabajo final de carrera se incluye dentro del tipo intervención profesional, debido a las características que el mismo presenta: una propuesta de extensión-comunicación.Facultad de Ciencias Agrarias y Forestale

Estrategia comunicacional de la UPID Semillas Hortícolas Locales: articulando saberes, potenciando espacios

Se trata de una tesis de grado, para alcanzar el título de Ingeniera Agrónoma. El trabajo final de carrera se enmarca dentro de las actividades desarrolladas desde la “UPID Semillas Hortícolas Locales del Cinturón Verde Platense”, unidad promocional de investigación y desarrollo perteneciente a la Facultad de Cs. Agrarias y Forestales. La actividad central de la UPID implica la revalorización, multiplicación y difusión de las semillas de distintas hortalizas típicas del gran La Plata. En base a información recabada en torno a las Hortalizas Típicas Locales –HTL- y al mundo cultural de los productores, así como de otros interlocutores, y -teniendo en cuenta distintas herramientas metodológicas- se ha llegado a conformar una estrategia comunicacional que aportará al cumplimiento de los objetivos de la UPID. Este trabajo final de carrera se incluye dentro del tipo intervención profesional, debido a las características que el mismo presenta: una propuesta de extensión-comunicación.Facultad de Ciencias Agrarias y Forestale

Educación integral de la sexualidad: Medio para la libertad

The shared experience refers to fifteen years of work in the field of sexuality, teaching the course "Sexuality Education" at Unit 31-A of the National Pedagogical University (UPN), Valladolid Branch, in the state of Yucatan, Mexico. The teaching of the course is strengthened by the focus on comprehensive sexuality education and is recognised as a necessary field of knowledge to be addressed in the academic training of people who are trained as Graduates in Educational Intervention (LIE) at the National Pedagogical University, by the changes in the way of recognising, understanding and accepting diversity in all its expressions in the thinking of the students who take the course, it is appreciated and valued that this training space better equips the students for their future action in the labour field. In addition to learning about their own bodies and sexuality, those who take this course are empowered as sexuality educators who can provide support to others who are experiencing violence of any kind or who have doubts about their sexual and reproductive rights.La experiencia que se comparte alude a quince años de trabajo en el campo de la sexualidad impartiendo el Curso "Educación de la Sexualidad" en la Unidad 31-A de la Universidad Pedagógica Nacional (UPN) Subsede Valladolid en el estado de Yucatán, México. La impartición del curso se fortalece con el enfoque de educación integral de la sexualidad y se reconoce un campo del conocimiento necesario a abordarse en la formación académica de las personas que se forman como Licenciadas en  Intervención Educativa (LIE) en la Universidad Pedagógica Nacional, por los cambios en la forma de reconocer, comprender y aceptar la diversidad en todas sus expresiones en el pensamiento de las personas alumnas toman el curso, se aprecia y valora que este espacio formativo habilita de mejor forma al estudiantado para su futuro actuar en el campo laboral. Las personas que toman este curso además de aprender sobre su propio cuerpo y sexualidad, se habilitan como educadoras sexuales que pueden ser apoyo para otras personas que sufren violencias de cualquier tipo o tienen dudas sobre sus derechos sexuales y reproductivos

Prevalence of Human Intestinal Entamoeba spp. in the Americas: A Systematic Review and Meta-Analysis, 1990–2022

Among the seven species of Entamoeba known to infect humans, E. histolytica is widely recognized as a pathogen. It is reported that Entamoeba infections are common in the developing world, but rare in developed countries. The best way to diagnose these protozoan parasites is to detect antigens or DNA in the stool. This study aimed to review the prevalence, distribution, and diagnosis methods of Entamoeba spp. infecting humans in the Americas between 1990 and 2022. A systematic review and meta-analysis were performed, including 227 studies on Entamoeba infections from 30 out of 35 American countries. The pooled prevalence of each species of Entamoeba was calculated using the random-effects model. The assignment of Entamoeba species was mainly performed by microscopy. The most widely distributed and prevalent species was E. coli (21.0%). Of the studies, 49% could not differentiate the species of the Entamoeba complex. The pathogenic species E. histolytica was distributed among 22 out of 30 American countries studied, with a pooled prevalence of 9%. Molecular data on Entamoeba species are still scarce. This is the first study that reviewed and summarized data on the prevalence of this protozoan genera among American countries.Fil: Servian, Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Estudios Parasitológicos y de Vectores. Universidad Nacional de La Plata. Facultad de Ciencias Naturales y Museo. Centro de Estudios Parasitológicos y de Vectores; ArgentinaFil: Helman, María Elisa. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Departamento de Epizootiología y Salud Pública. Laboratorio de Inmunoparasitología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; ArgentinaFil: Iglesias, María del Rosario. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Estudios Parasitológicos y de Vectores. Universidad Nacional de La Plata. Facultad de Ciencias Naturales y Museo. Centro de Estudios Parasitológicos y de Vectores; ArgentinaFil: Panti May, Jesús Alonso. Universidad Autonoma de Yucatan (uady);Fil: Zonta, Maria Lorena. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Estudios Parasitológicos y de Vectores. Universidad Nacional de La Plata. Facultad de Ciencias Naturales y Museo. Centro de Estudios Parasitológicos y de Vectores; ArgentinaFil: Navone, Graciela Teresa. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Estudios Parasitológicos y de Vectores. Universidad Nacional de La Plata. Facultad de Ciencias Naturales y Museo. Centro de Estudios Parasitológicos y de Vectores; Argentin

Coexistence of Two Kinds of Fluorinated Hydrogenated Micelles as Building Blocks for the Design of Bimodal Mesoporous Silica with Two Ordered Mesopore Networks

A simple and effective route has been developed for the synthesis of bimodal (3.6 and 9.4 nm) mesoporous silica materials that have two ordered interconnected pore networks. Mesostructures have been prepared through the self assembly mechanism by using a mixture of polyoxyethylene fluoroalkyl ether and triblock copolymer as building block. The investigation of the RF8(EO)9/P123/water phase diagram evidences that in the considered surfactant range of concentrations, the system is micellar (L1). DLS measurements indicate that this micellar phase is composed of two types of micelles, the size of the first one at around 7.6 nm corresponds unambiguously to the pure fluorinated micelles. The second type of micelles at higher diameter consists of fluorinated micelles which have accommodated a weak fraction of P123 molecules. Thus, in this study the bimodal mesoporous silica are really templated by two kinds of micelles