Lektinorientierte Forschung an Viscum Album (Mistel) Abschlussbericht

SIGLEAvailable from TIB Hannover: DtF QN1(55,2) / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekBundesministerium fuer Forschung und Technologie (BMFT), Bonn (Germany)DEGerman

Inhibition of cholinesterase gene expression by chemically modified hammerhead ribozymes Final report

Available from TIB Hannover: F98B1574 / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekSIGLEGerman-Israeli Foundation for Scientific Research and Development (GIF), Oberschleissheim (Germany)DEGerman

Automatische Auswertung von Elektropherogrammen und Chromatogrammen mit Methoden der digitalen Bildverarbeitung Schlussbericht

SIGLECopy held by FIZ Karlsruhe; available from UB/TIB Hannover / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekDEGerman

Therapie mit molekulargenetischen Methoden. Entwicklung von Methoden und Modellen zur molekulargenetischen Therapie hereditaerer Bewegungsstoerungen Schlussbericht

SIGLEAvailable from TIB Hannover: DtF QN1(90,45) / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekBundesministerium fuer Bildung, Wissenschaft, Forschung und Technologie, Bonn (Germany)DEGerman

Neurotoxine und Neuroprotektion: Bedeutung radikalischer Mechanismen und der Atmungsketteninhibition fuer die Aetiologie des Parkinsonsyndroms, der Neurodegeneration und des Alterungsprozesses Schlussbericht

There are no animal models for the investigation of the causes and progression of neurodegenerative diseases - such as Parkinson's Disease -suitable for searching out the pathological mechanisms which may elicit and maintain a progressive disease process. Up till now only a few of the factors that might contribute to the multiactorial pathogenesis of Parkinson's Disease have been established. A large-scale depolyment of non-human primates could not be considered. Rats, subjected to oxidative stress, exhibit a gradually developing assortment of pathological symptoms which strikingly involve the mediation of the dopaminergic system. The pathological symptoms are susceptible to therapeutic interventions. The animals undergo various stages of a set of pathological symptoms which manifests itself among others in a reluctance to undertake changes of rapid motor strategies. They exhibit a diminished ability to learn and to pay attention. Brain regions where such lesions may be elicited are highly specific. At an advanced age, the consequency of oxidative stress show a loss of the D1 mRNA in the dorsal statum without concomitant cell loss. (orig.)Available from TIB Hannover: F99B1195 / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekSIGLEBundesministerium fuer Bildung und Forschung (BMBF), Bonn (Germany)DEGerman