Evaluación de un método de medida de vergencias fusionales

EL objetivo de este trabajo es evaluar la aplicación Optotab, diseñada por Smarthings4vision para la medida de vergencias fusionales horizontales y verticales. Sobre una muestra de 25 pacientes hemos medido vergencias fusionales mediante vectogramas y estereogramas de puntos aleatorios con dicha aplicación y hemos comparado los resultados obtenidos con el método tradicional de medida de vergencias con barra de prismas. Del estudio se concluye que los distintos métodos no son intercambiables. El examinador deberá conocer los errores a que están sujetos, así como los valores normales con uno y otro método para poder interpretarlos correctamente

Multiancestry analysis of the HLA locus in Alzheimer’s and Parkinson’s diseases uncovers a shared adaptive immune response mediated by HLA-DRB1*04 subtypes

Across multiancestry groups, we analyzed Human Leukocyte Antigen (HLA) associations in over 176,000 individuals with Parkinson’s disease (PD) and Alzheimer’s disease (AD) versus controls. We demonstrate that the two diseases share the same protective association at the HLA locus. HLA-specific fine-mapping showed that hierarchical protective effects of HLA-DRB1*04 subtypes best accounted for the association, strongest with HLA-DRB1*04:04 and HLA-DRB1*04:07, and intermediary with HLA-DRB1*04:01 and HLA-DRB1*04:03. The same signal was associated with decreased neurofibrillary tangles in postmortem brains and was associated with reduced tau levels in cerebrospinal fluid and to a lower extent with increased Aβ42. Protective HLA-DRB1*04 subtypes strongly bound the aggregation-prone tau PHF6 sequence, however only when acetylated at a lysine (K311), a common posttranslational modification central to tau aggregation. An HLA-DRB1*04-mediated adaptive immune response decreases PD and AD risks, potentially by acting against tau, offering the possibility of therapeutic avenues