Evaluation of Economic Efficiency of Investment in a Firm

Tato bakalářská práce se zabývá hodnocením investičního projektu konkrétní společnosti působící v oboru strojírenství, která uvažuje o koupi nového přístroje pro 3D měření. Cílem je zhodnotit investiční varianty nákupu daného přístroje a navrhnout optimální řešení pro společnost, včetně způsobu financování. Výhodnost této investice je posuzována dle vybraných metod pro hodnocení ekonomické efektivnosti investice a na základě výpočtů těchto metod zjistím, zda je vhodné koupi realizovat či nikoliv.This bachelor thesis deals with the evaluation of investment project of specific companies operating in the field of engineering which are considering buying a new device for 3D measurements. The objective is to evaluate investment options buying the equipment and propose the optimal solution for the company, including financing. The advantage of this investment is to be judged by selected methods for evaluating the economic efficiency of the investment and based on calculations of these methods, to find out whether it is appropriate to implement the purchase or not.

Analysis of Economic Data Using Statistical Methods

Tato diplomová práce se zabývá zhodnocením finanční situace podniku pomocí vybraných ukazatelů finanční analýzy s použitím analýzy časových řad a regresní analýzy. Práce je rozdělena na dvě části. Teoretická část práce se zaměřuje na problematiku ekonomických ukazatelů finanční analýzy, jejich interpretace a také na časové řady. Praktická část práce se zabývá analýzou ekonomických ukazatelů, které budou následně podrobeny analýze statistické, která se snaží pomocí statistických metod analyzovat vývoj jednotlivých ukazatelů a na základě hodnot z minulých období predikovat jejich budoucí vývoj.This master‘s thesis evaluates the financial situation of the company using selected indicators of financial analysis using time series analysis and regression analysis. Theses is separated into two parts. The theoretical part focuses on the issue of economic indicators, financial analysis, interpretation and on time series. The practical part deals with analysis of economic indicators, which will then be subjected to statistical analysis, which tries using statistical methods to analyse the trend of individual indicators and on the basis of values from previous periods to predict future developments.

The corrosion effect of fly ash from biomass combustion on andalusite refractory materials

The main problem affecting the life of refractory linings in furnaces is alkaline corrosion formed during biomass combustion, especially in systems with SiO2–Al2O3 . This corrosion effect is very intensive compared to using conventional technologies designed for burning traditional fuels. This study focuses on the development of a new type of andalusite refractory material with a higher corrosion resistance to K2CO3 and fly ash after biomass combustion. The original andalusite refractory material is labeled A60PT0, with an oxide content of 60 wt.% Al2O3 and 37 wt.% SiO2 , a compressive strength parameter of 64 MPa, and an apparent porosity of 15%. In the experiment, four mixtures (labeled A60PT1–A60PT4) were modified primarily using the raw materials and granulometry. The fly ash was characterized by an X-ray diffraction analysis with the following phases: quartz, calcite, microcline, leucite, portlandite, and hematite. According to the X-ray fluorescence analysis, the samples contained the following oxides: 47 wt.% CaO, 12 wt.% K2O, 4.6 wt.% SiO2 , 3.5 wt.% MgO, and some minority oxides such as P2O5 , MgO, MnO, and Fe2O3 between 2 and 5 %. The tendency for slagging/fouling of the ash was determined with the help of the indexes B/A, TA, Kt , and Fu. The final material was a shaped andalusite refractory material labeled A60PT4 with a content of 65 wt.% Al2O3 and 36 wt.% SiO2. The properties of the andalusite material were a compressive strength of 106.9 MPa, an apparent porosity of 13%, and the recommended temperature of use up to 1300 ◦C. For corrosion testing, a static crucible test was performed according to the norm CSN CEN/TS 15418 and ˇ the company’s internal regulation. The exposure time of the samples was 2 h and 5 h at temperatures of 1100 ◦C and 1400 ◦C for K2CO3 and ash, respectively. For the evaluation of tested samples, an X-ray powder differential analysis, an X-ray fluorescence analysis, scanning electron microscopy, and energy-dispersive X-ray spectroscopy were used.Web of Science133art. no. 35

Complete genome sequence of Treponema pallidum ssp. pallidum strain SS14 determined with oligonucleotide arrays

<p>Abstract</p> <p>Background</p> <p>Syphilis spirochete <it>Treponema pallidum </it>ssp. <it>pallidum </it>remains the enigmatic pathogen, since no virulence factors have been identified and the pathogenesis of the disease is poorly understood. Increasing rates of new syphilis cases per year have been observed recently.</p> <p>Results</p> <p>The genome of the SS14 strain was sequenced to high accuracy by an oligonucleotide array strategy requiring hybridization to only three arrays (Comparative Genome Sequencing, CGS). Gaps in the resulting sequence were filled with targeted dideoxy-terminators (DDT) sequencing and the sequence was confirmed by whole genome fingerprinting (WGF). When compared to the Nichols strain, 327 single nucleotide substitutions (224 transitions, 103 transversions), 14 deletions, and 18 insertions were found. On the proteome level, the highest frequency of amino acid-altering substitution polymorphisms was in novel genes, while the lowest was in housekeeping genes, as expected by their evolutionary conservation. Evidence was also found for hypervariable regions and multiple regions showing intrastrain heterogeneity in the <it>T. pallidum </it>chromosome.</p> <p>Conclusion</p> <p>The observed genetic changes do not have influence on the ability of <it>Treponema pallidum </it>to cause syphilitic infection, since both SS14 and Nichols are virulent in rabbit. However, this is the first assessment of the degree of variation between the two syphilis pathogens and paves the way for phylogenetic studies of this fascinating organism.</p

Complete Genome Sequence of Treponema paraluiscuniculi, Strain Cuniculi A: The Loss of Infectivity to Humans Is Associated with Genome Decay

Treponema paraluiscuniculi is the causative agent of rabbit venereal spirochetosis. It is not infectious to humans, although its genome structure is very closely related to other pathogenic Treponema species including Treponema pallidum subspecies pallidum, the etiological agent of syphilis. In this study, the genome sequence of Treponema paraluiscuniculi, strain Cuniculi A, was determined by a combination of several high-throughput sequencing strategies. Whereas the overall size (1,133,390 bp), arrangement, and gene content of the Cuniculi A genome closely resembled those of the T. pallidum genome, the T. paraluiscuniculi genome contained a markedly higher number of pseudogenes and gene fragments (51). In addition to pseudogenes, 33 divergent genes were also found in the T. paraluiscuniculi genome. A set of 32 (out of 84) affected genes encoded proteins of known or predicted function in the Nichols genome. These proteins included virulence factors, gene regulators and components of DNA repair and recombination. The majority (52 or 61.9%) of the Cuniculi A pseudogenes and divergent genes were of unknown function. Our results indicate that T. paraluiscuniculi has evolved from a T. pallidum-like ancestor and adapted to a specialized host-associated niche (rabbits) during loss of infectivity to humans. The genes that are inactivated or altered in T. paraluiscuniculi are candidates for virulence factors important in the infectivity and pathogenesis of T. pallidum subspecies

Whole Genome Sequences of Three Treponema pallidum ssp. pertenue Strains: Yaws and Syphilis Treponemes Differ in Less than 0.2% of the Genome Sequence

Spirochete Treponema pallidum ssp. pertenue (TPE) is the causative agent of yaws while strains of Treponema pallidum ssp. pallidum (TPA) cause syphilis. Both yaws and syphilis are distinguished on the basis of epidemiological characteristics and clinical symptoms. Neither treponeme can reproduce outside the host organism, which precludes the use of standard molecular biology techniques used to study cultivable pathogens. In this study, we determined high quality whole genome sequences of TPE strains and compared them to known genetic information for T. pallidum ssp. pallidum strains. The genome structure was identical in all three TPE strains and also between TPA and TPE strains. The TPE genome length ranged between 1,139,330 bp and 1,139,744 bp. The overall sequence identity between TPA and TPE genomes was 99.8%, indicating that the two pathogens are extremely closely related. A set of 34 TPE genes (3.5%) encoded proteins containing six or more amino acid replacements or other major sequence changes. These genes more often belonged to the group of genes with predicted virulence and unknown functions suggesting their involvement in infection differences between yaws and syphilis

Teaching a second language in early childhood

Katedra pedagogikyFaculty of EducationPedagogická fakult

German Language in the Field of Education and Practice: Situation of Teaching German Language at Primary and Secondary Schools and its Comparison with the Needs of the Practice illustrated on the Example of the Sokolov Region

Tato bakalářská práce se zabývá situací ve výuce německého jazyka na základních a středních školách na Sokolovsku a následným uplatněním nabytých znalostí německého jazyka v komerční sféře, tzn. ve firmách působících v tomto okrese. Praktická část práce zahrnuje výzkum v oblasti školství, v jehož rámci byli osloveni učitelé a žáci dvanácti různých škol na Sokolovsku. V rámci výzkumu komerční sféry byli osloveni zaměstnavatelé, kteří se vyjadřovali především k otázkám souvisejícím se stávajícím jazykovým vybavením svých zaměstnanců.ObhájenoThis bachelor thesis deals with the present-day situation of teaching the German language at primary and secondary schools in the Sokolov District, which borders with Germany, as well as with the possibilities of the next use of the German language in the companies of this district. The practical part is divided into the research in the field of education system, and the field of the commercial sphere. The aim of the research at primary and secondary schools in the Sokolov District was to map the status of the German language among the students and the teachers. The aim of the research was to find out how much the German language is needed by the companies and what level of the German language is required from the employee

Web based applications for exercising and examination in language studies

TITLE: Web based applications for exercising and examination in language studies. SUMMARY: The aim of this bachelor thesis was to map accessible tools for language exercises and testing on the internet. Chosen applications were analysed and characterised on the basis of model tests evaluated in accordance to previously chosen criteria. Obtained data were processed in due course and recommendations for practical use of chosen applications were determined. KEYWORDS: didactic test, testing exercise, web interfac