10 research outputs found
Age of women and the number of antral follicles in predicting ovarian response in intrauterine insemination (IUI)
Background: Fertility specialists assess ovarian responses prior to estimating the prognosis for women who are suffering from anovulation. To diagnose the inconsistencies between chronological and biological age of ovaries and predict ovarian response, transvaginal sonography (TVS) ovarian act as an operant method. The aim of the current study was to assess the correlation between the number of antral follicles in both ovaries and the age of women in predicting the ovarian response in intrauterine insemination (IUI).Ā
Methods: The research design of the present study was a cross-sectional. A total of 171 individuals, who were non-smoker patients and had already undergone a standard regimen of ovarian stimulation for IUI, were selected as participants of this study from the Infertility and Reproductive Health Research Center in Babol (Iran). On the third day of the cycle, TVS was conducted to measure the mean of every ovary and also to count the number of antral follicles on the both ovaries.Ā
Results: The mean age of our patients was 27.7. The increased aged of women is significantly associated with lower total number of antral follicles. (P = 0.001). The mean ovarian diameter was significantly correlated with high number of antral follicles (p = 0.0001).Ā
Conclusion: The findings of the present study indicated that the age of women and the ovarian diameter are leading factors to help determine ovarian response as well as basal antral follicle counts
Vaginal wall cysts in a prepubertal girl: a case report
A vaginal cyst is an encapsulated sac, situated on or under the lining of vagina, and contains liquid
or semi liquid substance. Vaginal cysts have rarely proved to be more troublesome than causing a
bit of discomfort and slight pain, but in some cases, they can develop into tumors. A 5-year-old
girl, who was complaining about a weird pain in her lower abdomen, was referred to the
gynecology center of the hospital. Ultrasonography revealed a vague large cyst in her uterus and
vagina. Surgical procedure was necessary to remove it. The patient was followed up for 6 months,
and no sign of recurrence of the cyst was observed
Impact of dexamethason
Objective: Infertile women with polycystic ovary (PCOs) involve with anovulatory cycles. Various adjuvant treatments have been suggested to improve ovarian response in these patients. In this study, we aimed to evaluate the role of dexamethasone in the outcome of IVF/ICSI in PCOs infertile women. Study design: 129 PCOs infertile women undergone IVF/ICSI were enrolled for this single blind clinical trial study in 2012ā2013. Setting: Fatemezahra Infertility and Reproductive Health Research Center, Babol University of Medical Sciences, Babol, Iran. Method: 43 patients who underwent IVF received dexamethasone (0.5Ā mg, 4Ā tab/day) in the treatment group and 74 patients were considered as the placebo group. Main outcome measure: Pregnancy rate was compared between the two groups. In addition, number of dominant follicle, oocytes retrieved, embryos transferred, and number of gonadotropin ampoule were evaluated. Results: The pregnancy rate in the group receiving dexamethasone was 17.5% significantly higher versus 4.3% in the placebo group (PĀ <Ā 0.05). The mean number of embryos in the patients received dexamethasone was 6.7Ā Ā±Ā 4.3, significantly greater than placebo which was 4.9Ā Ā±Ā 4.9 (PĀ <Ā 0.05). The mean number of gonadotropin ampoules used in the group received dexamethasone was 3.5Ā Ā±Ā 1.6, significantly lower versus the placebo which was 5.3Ā Ā±Ā 2.5 (PĀ <Ā 0.05). The mean number of oocytes in the group received dexamethasone was 11.8Ā Ā±Ā 8 and in the placebo group was 9.6Ā Ā±Ā 5.8 that was not significant. Conclusion: Dexamethasone enhances embryos and pregnancy rate; in addition, it reduces gonadotropines ampoule used for stimulation, hence, and we recommend using of dexamethasone in women with PCOs undertreatment of IVF/ICSI
Maternal serum C - reactive protein and fibrinogen concentration in women with pre-eclampsia
Background: Despite many studies published in recent years concerning pathogenic
mechanisms of pre-eclampsia, but this issue remains controversial. The aim of the present study
was to compare C-reactive protein (CRP) level and fibrinogen concentration obtained from
pregnant women with pre-eclampsia with those obtained from women with normal pregnancies.
Methods: In a case-control study, 40 pregnant women with mild pre-eclampsia were studied. The
maternal serum CRP and fibrinogen concentration of the 40 patients were compared with 55
pregnant women with non-preeclampsia as a control group. CRP was examined using quantitive
nephlometry and fibrinogen concentration was measured by clotting system. An independent
sample t-test was used for analysis.
Results: Maternal serum CRP was higher in women pregnant with pre-eclampsia compared with
those from pregnant women normal pregnancies (p= 0.01). The independent t-test did not reveal
any statistically significant differences in the fibrinogen concentration between these pregnant
women, either with or without pre-eclampsia.
Conclusion: The findings of this study indicated that a novel increased CRP was identified
among pregnant women with pre-eclampsia, making inflammatory marker as a promising new
approach for the detection of pre-eclampsi
Are children born through Intra-Cytoplasmic Sperm Injection (ICSI) having a lower intelligence quotient?
Background: There is still concern about delayed mental development for children born through Intra-Cytoplasmic Sperm Injection (ICSI). In the present study, the intelligence quotient (IQ) of ICSI children at the age of 5ā6Ā years was compared with that of the control group of naturally born (NB) children. Outcome measure: Full-scale IQ of the mental development in children born through ICSI in 5ā6Ā years. Design: Cross-sectional study. Setting: Fatemehzahra Infertility and Reproductive Health Research Center of Babol ā Iran. Participants: 28 live-birth singleton children 5ā6Ā years of the first generation born after ICSI treatment. Methods: The mental development of 28 born through ICSI children at 5ā6Ā years compared with 32 naturally born children as control using intelligence quotient (IQ) test obtained from the Wechsler Preschool and Primary Scale of Intelligence (WPPSI) (Iranian version). Results: The mean full-scale IQ was 105.9Ā Ā±Ā 14 for ICSI and 107.2Ā Ā±Ā 12.9 for NB children which showed no significant difference. The only significant possible predictors of slightly lower full-scale IQ in ICSI children were lower parental education level and longer childcare in day center. Conclusion: Our finding provides some reassurance for parents of children born through ICSI regarding the childās preschool IQ
Womenās satisfaction in early versus delayed postcaesarean feeding: A one-blind randomized controlled trial study
Background: The early
postoperative feeding after caesarean
section (C-
section) has remained controversial.Ā This study was designed to evaluate the
safety and efficacy of early versus delayed postcaesarean section oral feeding
regarding gastrointestinal complications and patients postoperative satisfaction
after C-
section.Ā Methods: This clinical trial study was conducted on
200 pregnant women undergoing planned C-section under
spinal anesthesia (Registration Number: IRCT: 138712211760N1). Women were randomly divided in
two groups group A (early feeding group) comprised of 101 patients who were
encouraged to take oral ļ¬uid. If they tolerated, they continue semi-solid and
solid foods starting 2 h after caesarean section. Group B (delayed
feeding group) comprised of 99 patients who were given oral ļ¬uid 8 h after
surgery. After beginning of feeding the patientsā tolerance,
first flatus, first defecation, beginning of regular diet, the length of
hospital stay and also patient satisfaction level were evaluated in each group by
visual scale analog (VAS).Ā Results: The mean time of the ļ¬rst passage of ļ¬atus
was 10.2Ā±1.7 hours for the early oral feeding group versus 10.7Ā±1.6 hours for the
delayed feeding group and the difference was significant (P=0.03). Duration to
first defecation and length of
hospital stay as well as
patient satisfaction level did not differ significantly between the two groups.
Ā Conclusion: The results of this study suggest early postcaesarean
feeding. It is well tolerated and helps return normal feeding habits
Short, semi-short or long GnRH agonist treatment regimens in women ICSI candidate; which is proper in
Objectives: Investigation of two discontinuous GnRH agonist (GnRH-a) protocols (Short and semi-short) versus traditional long protocol in preventing premature LH surge in women undergoing Intra-cytoplasmic sperm injection (ICSI). Study design: Single blind randomized trial study. Setting: Fatemezahra Infertility and Reproductive Health Research Center, Babol, Iran. Materials and methods: 139 patients who were undergone ICSI, randomly divided into three groups. In short protocol group (nĀ =Ā 40), GnRH-a (buserelin acetate) was initiated midluteally and ceased at the onset of the next cycle. Group of semi-short protocol (nĀ =Ā 41) initiated GnRH-a the same as short protocol group and discontinued at the fourth day of the next cycle. Group of long protocol (nĀ =Ā 38) was initiated midluteally and continued until the day of HCG injection. Ovarian stimulation was performed with gonadotropin. As primary outcome occurrence of premature LH surge was evaluated and as secondary outcome the duration and total dose of consumed gonadotropin, number of oocytes retrieval, number of formed blastocyst and pregnancy rate were investigated. Main outcome measures: No undesired LH surge occurred in the three groups, although the mean of LH at administration day of HCG was significantly higher in short protocol group (PĀ ā©½Ā 0.05). No significant difference was observed in the number of mature oocyte, and number and quality of blastocyst, duration and total dose of consumed gonadotropin and pregnancy rate among three groups. Major conclusion: In the ICSI protocol, discontinuation of GnRH-a on the first or fourth day of ovarian stimulation does not enhance a premature LH surge
The effect of dexamethasone therapy on prolonged latent phase of labor: a randomized double-blind clinical trial
Background: Shortening the interval between the onset of labor and delivery is useful for both mothers and fetuses. The aim of the study was to investigate the effect of dexamethasone on the augmentation and the duration of labor in prolonged latent phase of labor.
Method: The design of the study was a randomized double-blind clinical trial design, which was conducted in delivery center of Rouhani hospital in Babol (Iran). A total 121 nulliparrous women with a singleton pregnancy and cephalic presentation at 40ā42 gestational weeks in prolonged latent phase were randomly assigned to receive 2 ml ampoule dexamethasone 4 mg/mL (the intervention group) and 2 ml ampoule of sterile water for injections (the control group), which were both intramuscularly administered. Then, the Then, the augmentation of labor with the use of intravenous oxytocin infusion (Caspian Tamin Company Iran) (2.5 m units/ per minute) began in both groups. The primary outcome was the duration of time between the onset of augmentation and the second stage of labor.
Results: The duration of time between the onset of labor augmentation and the second stage of labor (hours) was 5.6Ā±1.9 in the study group, whereas it was 7.7Ā±1.5 in controls with a significant difference (p ā¤ <0.001). In the study group, the duration of time between the onset of labor augmentation and the active phase of labor was lower than that of the control group (p= 0.02). In addition, the duration of the second stage of labor (p <0.001) and the third stage (p <0.001) was lower in the study group compared with that of the control group.
Conclusion: It is imperative that midwives administer dexamethasone to improve the prolonged latent phase in women during the labor
Thyroid-stimulating hormone (TSH) and pregnancy outcome in patients undergoing in vitro fertilization (IVF)
Introduction: Subclinical hypothyroidism is related to poor outcome of pregnancy, which is reported in more recent researches. The aim of this study was to determine the correlation between pre-conception of thyroid-stimulating hormone (TSH) level and pregnancy outcomes in patients undergoing in vitro fertilization (IVF).
Ā Methods: This retrospective cohort study was done on 115 IVF candidate patients undergoing long protocol of ovulation induction that became pregnant from 2007 to 2012. Pregnancy outcomes, including abortion rate, termination age of pregnancy and birth weight in women with low pre-conception TSH (ā¤2.5 mIU/L) and high pre-conception TSH (>2.5 mIU/L) were compared with each other.
Results: AmongĀ 115 pregnancies, 30.2% of the women had pre-conception TSH >2.5 mIU/L. Preterm delivery (2.5 than them with a pre-conception TSH ā¤2.5 (P= 0.044). There was no statistically significant difference in abortion, pregnancy termination, and birth weight between two groups.Ā A pre-conception thyroid-stimulating hormone level >2.5 mIU/L is associated with a lower gestational age at delivery in women undergoing in vitro fertilization.
Conclusion:Ā The results of this research indicated that a pre-conception thyroid-stimulating hormone level >2.5 associated with preterm labor in women undergoing IVF. Therefore, it is suggested that screening for hypothyroidism before IVF could be have significant public health implications
Obese women with polycystic ovary syndrome and Pregnancy: a case report and a literature review
Many women with polycystic ovary (PCO) are obese. These women have lower clinical pregnancy
rates when compared with their lighter counterparts. We hereby present a case of an obese PCOs
woman, who referred to our clinic, underwent a microinjection, and failed in pregnancy. Then, she
was recommended to have a change of lifestyle and lose weight along taking insulin-sensitizer
medicines. In the following 6 months, she lost 19 Kilograms and referred to us with a spontaneous
pregnancy. The object of this report was to determine the role of insulin intolerance medicines and
lifestyle improvement on enhancing the rate of pregnancy in the PCOs obese women