Una llum d'esperança : alumnes repetidors com a monitors de pràctiques. Experiència a segon curs de la Llicenciatura en Medicina

Amb l'ànim d'ajudar als estudiants que tenen problemes a la assignatura "Estructura Microscòpica d'Aparells i Sistemes Humans" de 2n curs de la llicenciatura de Medicina i que la suspenen reiteradamet, el curs 2005-2006 vam iniciar un nou projecte d'innovació docent basat en l'èxit de l'experiència dels professors i monitors de l'assignatura de Neuroanatomia de segon curs de Llicenciatura en medicina durant el curs 2004-2005

El Septum dorsal de la lagartija común (Podarcis hispanica) : un estudio con los métodos de Golgi, M.E., TIMM-M.E. y con la técnica de la HRP (peroxidasa de rábano) /

Consultable des del TDXTítol obtingut de la portada digitalitzadaVegeu resum1de1.pd

ABP integral en histología (teoria i pràctiques), una experiència amb èxit a la Facultat de Medicina

A la nostra Unitat tenim la responsabilitat de dues assignatures de la Llicenciatura de Medicina: (1) Histologia Mèdica (HM), semestral, troncal de 1r curs de 4,5 crèdits (3 crèdits teòrics i 1,5 crèdits pràctics). Al curs 2006-07 es varen matricular 387 estudiants. (2) Estructura Microscòpica d'Aparells I Sistemes Humans (EMASH), anyal, troncal de 2n curs de 9 crèdits (4,5 crèdits teòrics i 4,5 crèdits pràctics. Al curs 2006-07 es varen matricular 298 estudiants.En els darrers anys el nostre objectiu ha sigut migrar des de un mètode docent tradicional de classes magistrals fins a un mètode tipus ABP (Aprenentatge Basat en Problemes) integral (teoria i pràctiques), que a més a més seguís les directius del Protocol de Bolònia per tal d'integrar aquestes assignatures a un nou programa docent de la Llicenciatura a l' EEES (Espai Europeu d'Educació Superior)

In vitro Natural Killer Cell Immunotherapy for Medulloblastoma

How the immune system attacks medulloblastoma (MB) tumors effectively is unclear, although natural killer (NK) cells play an important role in immune defense against tumor cells. Interactions between receptors on NK cells and ligands expressed by tumor cells are critical for tumor control by immunotherapy. In this study, we analyzed tumor samples from 54 MB patients for expression of major histocompatibility complex class I-related chains A (MICA) and UL16 binding protein (ULPB-2), which are ligands for the NK group 2 member D activatory receptor (NKG2D). The percentage of MICA and ULBP-2 positive cells was higher than 25% in 68% and 6% of MB patients, respectively. A moderate-high intensity of MICA cytoplasmic staining was observed in 46% MB patients and weak ULBP-2 staining was observed in 8% MB patients. No correlation between MICA/ULBP-2 expression and patient outcome was found. We observed that HTB-186, a MB cell line, was moderately resistant to NK cell cytotoxicity in vitro. Blocking MICA/ULBP-2 on HTB-186, and NKG2D receptor on NK cells increased resistance to NK cell lysis in vitro. However, HLA class I blocking on HTB-186 and overnight incubation with IL-15 stimulated NK cells efficiently killed tumor cells in vitro. We conclude that although NKG2D/MICA-ULBP-2 interactions have a role in NK cell cytotoxicity against MB, high expression of HLA class I can protect MB from NK cell cytotoxicity. Even so, our in vitro data indicate that if NK cells are appropriately stimulated, they may have the potential to target MB in vivo

Dependencia en los estilos de aprendizaje del alumnado de Educación Primaria e Infantil: el avance hacia un desarrollo competencial autónomo a través del uso de materiales de aprendizaje y evaluación a través de la tutorización entre iguales

El alumnado de referencia está predispuesto a aprendizajes dependientes a pesar de los cambios en la metodología universitaria. Se pretende innovar en este campo diseñando un programa de tutorización entre iguales en el contexto de cada asignatura

Dynamic Permittivity Measurement of Ground-Tire Rubber (GTR) during Microwave-Assisted Devulcanization

[EN] Many efforts are being made to find innovative ways of recycling rubber from end-of-life tires (ELTs), also called ground tire Rubber (GTR). Recycling through devulcanization allows the reintroduction of rubber back into the manufacturing industry. Such a process requires providing enough energy to break the sulfur links, while preventing damage to the polymeric chain. Microwave heating is controllable, efficient, and it does not rely on conventional heating mechanisms (conduction, convection) which may involve high heating losses, but rather on direct dielectric heating. However, to adequately control the microwave-assisted devulcanization performance, a thorough knowledge of the GTR permittivity versus temperature is required. In this work, GTR permittivity was monitored during its devulcanization. A resonant technique based on a dual-mode cylindrical cavity was used to simultaneously heat rubber and measure its permittivity at around 2 GHz. The results show sharp changes in the GTR permittivity at 160 and 190 degrees C. After the GTR cooled down, a shifted permittivity evidences a change in the GTR structure caused by the devulcanization process. Microwave-assisted devulcanization effectiveness is proven through time-domain nuclear magnetic resonance (NMR) measurements, by verifying the decrease in the cross-link density of processed GTR samples compared to the original sample.This research project has received funding from the European Union's Horizon 2020 research and innovation program under grant agreement number 870,000. More information at https://cordis.europa.eu/project/id/870000 (accessed on 27 August 2022) and https://valuerubber.eu/(accessed on 27 August 2022). JLV and FMS also thanks the funding from Ministerio de Ciencia e Innovacion (PID2020-119047RB-I00 y PLEC2021-007793), Gobierno de Aragon (EC-22-2021) and CSIC (201860E045).Pérez-Campos, R.; Fayos-Fernández, J.; Monzó-Cabrera, J.; Martín Salamanca, F.; López Valentín, J.; Catalá Civera, JM.; Plaza González, PJ.... (2022). Dynamic Permittivity Measurement of Ground-Tire Rubber (GTR) during Microwave-Assisted Devulcanization. Polymers. 14(17):1-21. https://doi.org/10.3390/polym14173543121141

Coverage changes of pine trees at risk in collection sites in northern Mexico

Objective: Analyze changes in land use and vegetation (USyV; from 1985 to 2014) in the collection sites of 16 pines listed in NOM-059-SEMARNAT-2010 located in northern Mexico. Design/methodology/approach: We integrate a georeferenced database of the species under study from consultations of botanical collections. A point coverage was created to add USyV vector information from Series I (1985) and VI (2014). Subsequently, spatial analysis and geoprocessing identified class changes during the period. Results: A total of 2,242 georeferenced records of pine species were obtained. The results indicated that 50.0 % of the total number of pine records consulted in collections with Series I information are in other USyV categories than primary forest. At the same time, with Series VI, this condition rises to 58.7 %. Consequently, the most critical changes in the period under study occurred in converting primary forests to agriculture, pasture, secondary vegetation of coniferous and oak forests, and urban areas. Limitations/implications: The availability of larger scale cartographic material, to generate a risk analysis study of changes and threats to the conservation of pine species. Findings/conclusions: The number of collection sites recorded in primary coniferous, scrub, and oak forests in Series I decreased significantly compared to Series VI, shifting to agriculture, water bodies, grassland, and urban areas.Objective: To analyze the changes in land-use and vegetation (LUV), from 1985 to 2014, in the sites in northern Mexico where 16 pine trees listed in the NOM-059-SEMARNAT-2010 are collected. Design/Methodology/Approach: Based on consultations in botanical collections, a georeferenced database of the species under study was developed. A point coverage was created to which LUV vector information from Series I (1985) and VI (2014) was added. Subsequently, LUV class changes were identified during the evaluation period through spatial analysis and geoprocessing. Results: A total of 2,242 georeferenced records of pine species were obtained. Fifty percent of the pine records consulted in collections with Series I information belong to other non-primary forest categories of LUV, while with Series VI information with this condition rose to 58.7%. Consequently, in the study period major changes occurred in the conversion of primary forests to agricultural lands, pasture, secondary vegetation in coniferous and oak forests, and mainly urban areas. Limitations/Implications: The availability of larger-scale cartographic material limited the generation of a risk analysis study about the changes and threats to forest conservation. Findings/Conclusions: The number of collection sites registered in coniferous forest, scrubland, and primary oak forest in Series I —which are now agricultural lands, water bodies, pastures, and urban areas— was significantly lower than in Series VI

Decreased salivary lactoferrin levels are specific to Alzheimer's disease

Background: Evidences of infectious pathogens in Alzheimer's disease (AD) brains may suggest a deteriorated innate immune system in AD pathophysiology. We previously demonstrated reduced salivary lactoferrin (Lf) levels, one of the major antimicrobial proteins, in AD patients. Methods: To assess the clinical utility of salivary Lf for AD diagnosis, we examine the relationship between salivary Lf and cerebral amyloid-beta (A beta) load using amyloid-Positron-Emission Tomography (PET) neuroimaging, in two different cross-sectional cohorts including patients with different neurodegenerative disorders. Findings: The diagnostic performance of salivary Lf in the cohort 1 had an area under the curve [AUC] of 0.95 (0.911-0.992) for the differentiation of the prodromal AD/AD group positive for amyloid-PET (PET+) versus healthy group, and 0.97 (0.924-1) versus the frontotemporal dementia (FTD) group. In the cohort 2, salivary Lf had also an excellent diagnostic performance in the health control group versus prodromal AD comparison: AUC 0.93 (0.876-0.989). Salivary Lf detected prodromal AD and AD dementia distinguishing them from FTD with over 87% sensitivity and 91% specificity. Interpretation: Salivary Lf seems to have a very good diagnostic performance to detect AD. Our findings support the possible utility of salivary Lf as a new non-invasive and cost-effective AD biomarker.This study was supported by Dr. Carro grants from Instituto de Salud Carlos III (FIS15/00780, FIS18/00118), FEDER, Comunidad de Madrid (S2017/BMD-3700; NEUROMETAB-CM), and CIBERNED (PI2016/01). This study was also supported by research grants from the Spanish Ministry of Economy and Competitiveness (SAF201785310-R to Dr. Cantero, PSI2017-85311-P to Dr. Atienza); International Centre on ageing CENIE-POCTEP (0348_CIE_6_E to Dr. Atienza); and CIBERNED (CB06/05/1111 to Dr. Cantero). Dr. Bueno receives research funding from the Instituto de Salud Carlos III, Spain (PIE16/00021, PI17/01799). The H2H-Spain Study was supported in Spain by grant PIE16/00021 from Instituto Carlos III, Ministry of Science, Innovation and Universities, and additional funds from the Centro Nacional de Investigaciones Cardiovasculares (CNIC). The CNIC is supported by the Ministry of Economy, Industry and Competitiveness and the Pro CNIC Foundation, and is a Severo Ochoa Centre of Excellence (SEV-2015-0505). The funders had no role in the conceptualisation, study design, data collection analysis and preparation of this manuscript

Dependencia en los estilos de aprendizaje del alumnado de Educación Primaria e Infantil: el avance hacia un desarrollo competencial autónomo a partir del uso de materiales de aprendizaje y evaluación a través de la tutorización entre iguales

El alumnado de referencia está predispuesto a aprendizajes dependientes a pesar de los cambios en la metodología universitaria. Se pretende dar continuidad a un programa de tutorización entre iguales en el contexto de cada asignatura