The Grizzly, April 28, 1992

Earth Day 1992: Fun for All • CoreStates Grants Grant • UC History Majors Present Papers • U.C. a hit at U.N. • Holocaust Survivor Speaks • Scholarly Hat Trick in Biology • Political Cartoonist To Speak • Strunk Runs for Office • Spring Weekend Great Success • Concert Band & Jazz Ensemble Perform • Exam Schedule • Student Art Exhibition Opens, Awards Presented • Wismer\u27s Modern Art Spy • First Friends First • Sophomore Chats Tell All • Letter: Strunk Thanks Democrats • Men\u27s Lacrosse Splits Weekendhttps://digitalcommons.ursinus.edu/grizzlynews/1296/thumbnail.jp

The Grizzly, April 14, 1992

Ursinus Chooses Its Leaders • Viking Fiasco • Sieger Speaks • Economics Conference Held, Gilmour Wins Top Award • Songfest 1992 • Room Selection and Housing Update • The Perfect Day in Upper Perk • Carrot Top Captivates Crowd • Metallica Mosh Mania • French Speaks on Beethoven • The Sensual Sunbathers and Condom Machines • Choir Sings • Grubb\u27s Last Word • Viking Fest: The Other Side • Opinions Section Seeks New Assistants • Letter: What\u27s Done is Done • Men\u27s Lacrosse Starts Season with Three Straight Wins • Six UC Athletes Named Academic All-Conference • Baseball Wins Two Out of Threehttps://digitalcommons.ursinus.edu/grizzlynews/1295/thumbnail.jp

The Grizzly, February 8, 1994

Ursinus Celebrates 125 Years of Academics • An Evaluation of the 128 Credit System • In Celebration of Black History Month: Al Eaton Brings on His One-Man Show • Ursinus Crimes Reported • Who Freed South Africa? • Guys Pledging Begins on Friday • Suite Etiquette • Senior Profile: Craig Faucher • Airband \u2794 • Come out and Support a U.C. Senior • Berman to Receive Preservation Grant • Woodward Exhibit on Display • Bright Moments to Perform • An Internal Compass Spinning • Eats & Seats • Wrestlers Up to 9-1 • Ursinus Gymnastics Sets New Records • Personal Interest Workshops to be Held • UC Student Almost Becomes Phillies\u27 Biggest Phanhttps://digitalcommons.ursinus.edu/grizzlynews/1329/thumbnail.jp

The Grizzly, February 15, 1994

Pledging Meeting: First in a Series • Berry Announces Plans for Candidacy • Ursinus Given Laboratory Glassware as Gift • Airband to Help Local • Northeast Still Being Hit by Winter • Professor Profile: Tom Whalen • The Power of the Postcard • GALA Retools • Censorship Sucks • UC Baseball to Hold 4th Annual Baseball Clinic • Freshman Black Belt Profiled in National Karate Magazine • New Track & Field Coaches Hired • Wrestling Destroys All Competitionhttps://digitalcommons.ursinus.edu/grizzlynews/1330/thumbnail.jp

The Grizzly, February 2, 1993

Cowboys Tame Buffalo, 52-17 • Upsilon Phi Delta Approved • AIDS Quilt • Al Eaton\u27s We Are the Dream • Day For a King • Power Plays • Bernie Bernie Headflap Wins Battle of the Bands • Lorelei at Chateau Granieri • Ice Skating Fun • The Case of the Disappearing Sevs (Or: Why Collegeville\u27s Most Famous Convenient Mart Upped & Left) • Senior Profile: Chris Kakacek • The New Zack\u27s: Why Hike to WaWa? • What\u27s Up in Wellness • Character was an Issue, Again • The Importance of Effort and A Dream • UC Baseball Preview \u2793 • Gymnasts Hoping For Powerful Season • Lady Bears Make Playoffs • Swimmers Working Hard • Football Awards Banquet Held • Wrestlers Continue Excellence • Men\u27s Basketball Split Twohttps://digitalcommons.ursinus.edu/grizzlynews/1308/thumbnail.jp

Pan-cancer analysis of whole genomes

Cancer is driven by genetic change, and the advent of massively parallel sequencing has enabled systematic documentation of this variation at the whole-genome scale(1-3). Here we report the integrative analysis of 2,658 whole-cancer genomes and their matching normal tissues across 38 tumour types from the Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium of the International Cancer Genome Consortium (ICGC) and The Cancer Genome Atlas (TCGA). We describe the generation of the PCAWG resource, facilitated by international data sharing using compute clouds. On average, cancer genomes contained 4-5 driver mutations when combining coding and non-coding genomic elements; however, in around 5% of cases no drivers were identified, suggesting that cancer driver discovery is not yet complete. Chromothripsis, in which many clustered structural variants arise in a single catastrophic event, is frequently an early event in tumour evolution; in acral melanoma, for example, these events precede most somatic point mutations and affect several cancer-associated genes simultaneously. Cancers with abnormal telomere maintenance often originate from tissues with low replicative activity and show several mechanisms of preventing telomere attrition to critical levels. Common and rare germline variants affect patterns of somatic mutation, including point mutations, structural variants and somatic retrotransposition. A collection of papers from the PCAWG Consortium describes non-coding mutations that drive cancer beyond those in the TERT promoter(4); identifies new signatures of mutational processes that cause base substitutions, small insertions and deletions and structural variation(5,6); analyses timings and patterns of tumour evolution(7); describes the diverse transcriptional consequences of somatic mutation on splicing, expression levels, fusion genes and promoter activity(8,9); and evaluates a range of more-specialized features of cancer genomes(8,10-18).Peer reviewe

role of next generation sequencing technologies in personalized medicine

Following the completion of the Human Genome Project in 2003, research in oncology has progressively focused on the sequencing of cancer genomes, with the aim of better understanding the genetic basis of oncogenesis and identifying actionable alterations. The development of next-generation-sequencing (NGS) techniques, commercially available since 2006, allowed for a cost- and time-effective sequencing of tumor DNA, leading to a "genomic era" of cancer research and treatment. NGS provided a significant step forward in Personalized Medicine (PM) by enabling the detection of somatic driver mutations, resistance mechanisms, quantification of mutational burden, germline mutations, which settled the foundation of a new approach in cancer care. In this chapter, we discuss the history, available techniques, and applications of NGS in oncology, with a particular referral to the PM approach and the emerging role of the research field of pharmacogenomics