46 research outputs found
IZAZOVI TIJEKOM IZRADE SILABUSA ZA POTREBE KOLEGIJA ENGLESKOG JEZIKA STRUKE I i II (HUMANISTIÄKI I DRUÅ TVENI SMJER SVEUÄILIÅ TA U ZADRU)
Course development and syllabus design as a process within course development are frequently discussed issues within LSP. This paper strives to show the challenges that two ESP teachers faced in designing the most adequate syllabus for English for the Humanities and Social Sciences first year undergraduate students at the Centre for Foreign Languages (University of Zadar) within the given teaching context and in reference to its studentsā learning needs. The paper also shows how the challenges were approached and tackled. This paper can have implications for ESP/EAP teachers considering course development, syllabus design and materials development.Razvoj kolegija i izrada silabusa kao jedan od sastavnih procesa razvoja kolegija su Äeste teme rasprave unutar stranog jezika struke. U ovom se radu pokuÅ”alo prikazati izazove s kojima su se susrele dvije nastavnice tijekom izrade najoptimalnijeg silabusa za potrebe kolegija Engleski jezik struke I i II za humanistiÄki i druÅ”tveni smjer namijenjen studentima prve godine prediplomskog studija pri Centru za strane jezike (SveuÄiliÅ”te u Zadru) u odnosu na postojeÄi kontekst pouÄavanja i na potrebe njegovih studenata. Rad takoÄer pokazuje kako se prepoznatim izazovima pristupilo i kako ih se na koncu savladalo. Ovaj rad može poslužiti nastavnicima Engleskog jezika struke i Engleskog za akademske potrebe zainteresiranim za razvoj kolegija, izradu silabusa i izradu nastavnih materijala
Laboratorijska medicina u Å”eÄernoj bolesti: Conditio sine qua non kvalitetnog standarda zdravstvene zaÅ”tite
Harmonizirana i racionalna laboratorijska medicina utemeljena na znanstvenim dokazima jest conditio sine qua non kvalitetnog standarda zdravstvene zaÅ”tite osoba sa Å”eÄernom boleÅ”Äu. U ovom pregledu prikazane su aktualne moguÄnosti laboratorijske medicine u ostvarenju ciljeva Nacionalnog programa zdravstvene zaÅ”tite osoba sa Å”eÄernom boleÅ”Äu 2015.-2020. Ministarstva zdravlja Republike Hrvatske te prijedlog aktivnosti za unaprjeÄenje kvalitete podruÄja nužne za svrhovito i racionalno postizanje ciljeva. S obzirom na preventivnu prirodu Nacionalnog programa, fokus pregleda je na Å”iroko zastupljenim pretragama iz podruÄja opÄe medicinske biokemije. Ovaj pregled svjedoÄi o dugogodiÅ”njim strukturiranim aktivnostima koje laboratorijska medicina, zalaganjem prije svega kliniÄkog laboratorija Referentnog centra za Å”eÄernu bolest Republike Hrvatske, u tom smislu poduzima, no problematizira i brojna podruÄja koja joÅ” uvijek zahtijevaju znaÄajno i žurno unaprjeÄenje kvalitete. Å eÄerna bolest je paradigma nužnosti suradnje kliniÄke i javnozdravstvene medicine s laboratorijskom medicinom jer jedino zajedniÄka nastojanja u strukturiranim programima daju optimalna rjeÅ”enja. Nacionalni program predstavlja poticaj za unaprjeÄenje kvalitete i daljnje usklaÄivanje laboratorijske prakse u Hrvatskoj s meÄunarodnim standardima, na dobrobit oboljelih od Å”eÄerne bolesti
Results of the Archeological Excavation of a Late-Medieval Cemetery with SteÄaks at the KreÅ”iÄ Cemetery
U Älanku se donose rezultati arheoloÅ”kih istraživanja groblja sa steÄcima na lokalitetu KreÅ”iÄa greblje - PaoÄa, opÄina Äitluk. ArheoloÅ”ka graÄa koja se analizira dobivena je istraživanjem dijela nekropole na kojemu su se nalazila Äetiri steÄka. Istraživanja su važna zbog toga Å”to upotpunjuju dosad malobrojne podatke dobivene arheoloÅ”kim istraživanjem kao i malobrojne rezultate antropoloÅ”kih analiza ljudskog osteoloÅ”kog materijala. Rezultati bioarheoloÅ”ke analize, provedeni na ljudskom koÅ”tanom materijalu, sugeriraju da su stanovnici ovoga prostora bili svakodnevno izloženi teÅ”kome fiziÄkom radu.The article presents the results of the archeological excavation of a cemetery with steÄaks at the KreÅ”iÄ cemetery - PaoÄa, municipality of Äitluk. The analyzed archeological materials were obtained from excavating part of a necropolis containing four steÄaks. The research is important because it supplements the existing scanty data obtained from archeological excavations and the scanty results of anthropological analyses of human osteological materials. The results of the bio-archeological analysis conducted on the human bone samples suggest that the inhabitants of the region had been exposed to heavy physical labor on a daily basis
Diagnostic challenges of diabetic kidney disease
Diabetic kidney disease (DKD) is one of the most common microvascular complications of both type 1 and type 2 diabetes and the most common cause of the end-stage renal disease (ESRD). It has been evidenced that targeted interventions at an early stage of DKD can efficiently prevent or delay the progression of kidney failure and improve patient outcomes. Therefore, regular screening for DKD has become one of the fundamental principles of diabetes care. Long-established biomarkers such as serum-creatinine-based estimates of glomerular filtration rate and albuminuria are currently the cornerstone of diagnosis and risk stratification in routine clinical practice. However, their immanent biological limitations and analytical variations may influence the clinical interpretation of the results. Recently proposed new predictive equations without the variable of race, together with the evidence on better accuracy of combined serum creatinine and cystatin C equations, and both race- and sex-free cystatin C-based equation, have enabled an improvement in the detection of DKD, but also require the harmonization of the recommended laboratory tests, wider availability of cystatin C testing and specific approach in various populations. Considering the complex pathophysiology of DKD, particularly in type 2 diabetes, a panel of biomarkers is needed to classify patients in terms of the rate of disease progression and/or response to specific interventions. With a personalized approach to diagnosis and treatment, in the future, it will be possible to respond to DKD better and enable improved outcomes for numerous patients worldwide
Slobodni tiroksin i trijodtironin su povezani s bubrežnom funkcijom u normoalbuminuriÄnih eutireoidnih bolesnika sa Å”eÄernom boleÅ”Äu tipa 1
Both hypothyroidism and hyperthyroidism affect renal function. The aim of this
study was to investigate the relationship between parameters of thyroid function (TSH, free triiodothyronine
(FT3), and free thyroxine (FT4)) and parameters of renal function in patients with type 1
diabetes (T1DM). The study included 272 T1DM with normoalbuminuria and estimated glomerular
filtration rate (eGFR) > 60 ml/min-11.73m-2, normal thyroid function, and without antihypertensive
and antihyperlipidemic therapy. TSH significantly correlated with urinary albumin excretion rate
(UAE) (r=-0.15, p<0.05) and fT3 with serum creatinine (r=0.12, p<0.05). Furthermore, fT4 significantly
correlated with all renal function parameters (serum creatinine, eGFR and UAE (r=-0.12, 0.34
and -0.13, respectively, for all p<0.05)). Patients in the highest quartile of fT4 had significantly higher
eGFR levels compared to those in the lowest quartile (116 vs. 101 ml/min-11.73m-2, p<0.001). In logistic
regression analysis, after adjustment for covariates, fT3 and fT4 were significantly associated
with worsening of renal function parameters with odds ratios of 0.75 to 1.29. This study, conducted in
euthyroid T1DM with normoalbuminuria and eGFR > 60 ml/min-11.73m-2 without therapeutic intervention,
suggests that the thyroid function may be connected with renal function parameters even
in the euthyroid range.Hipotireoza kao i hipertireoza utjeÄu na bubrežnu funkciju. U ovoj studiji istraživali smo povezanost izmeÄu TSH, slobodnog
trijodtironina (sT3) i slobodnog tiroksina (sT4) s parametrima bubrežne funkcije u normoalbuminuriÄnih bolesnika
sa tipom 1 Å”eÄerne bolesti (Å B1). Studija je ukljuÄila 272 bolesnika sa Å B1 i normalnom funkcijom Å”titnjaÄe te prije terapije
statinima, ACE-inhibitorima ili blokatorima receptora angiotenzina 2. Studija je ukljuÄila bolesnike s glomerularnom filtracijom
(GF) > 60 mlmin-11.73m-2. sT4 je statistiÄki znaÄajno korelirao s serumskim kreatininom, GF i albuminurijom
(r=-0.12, 0.34 i -0.13, za sve p<0.05), TSH je statistiÄki znaÄajno korelirao s albuminurijom (r=-0.15, p<0.05) a sT3 s serumskim
kreatininom (r=0.12, p<0.05). Razina GF bila je znaÄajno viÅ”a u ispitanika u najviÅ”oj kvartili sT4 u usporedbi s onim u
najnižoj kvartili (116 prema 101 ml min-1 1.73m-2, p<0.001). U logistiÄkoj regresiji, nakon prilagodbe za dob, spol, indeks
tjelesne težine, trajanje Å”eÄerne bolesti i HbA1c, sT3 i sT4 bili su statistiÄki znaÄajno povezani s rizikom od pogorÅ”anja
bubrežne funkcije u naÅ”ih bolesnika s omjerom izgleda (odds ratios) izmeÄu 0.75 i 1.29. Ova studija, provedena na eutireotiÄnim
normoalbuminuriÄnim bolesnicima s Å B1 bez terapijskih intervencija, ukazala je da je utjecaj funkcije Å”titnjaÄe na
parametre bubrežne funkcije prisutan veÄ i u stanju eutireoze
Hemoglobin A1c: Standardization of the āgold standardā
Hemoglobin A1c (HbA1c) je u proteklih 30 godina primjene postao "zlatnim standardom" u kliniÄkom praÄenju Å”eÄerne bolesti. Dobra kontrola glikemije, izražena kroz koncentraciju HbA1c ā¤7%, danas je kliniÄki normativ kroz koji se procjenjuje djelotvornost terapije i rizik pojave komplikacija Å”eÄerne bolesti i glavna tema komunikacije izmeÄu dijabetologa i pacijenata.
Raznovrsna i nestandardizirana metodologija, varijabilnost kemijskih entiteta nastalih glikacijom molekule hemoglobina i nepostojanje primarnoga referentnog materijala znaÄajno utjeÄu na pouzdanost primjene HbA1c u kliniÄkoj praksi. MeÄunarodna federacija za kliniÄku kemiju i laboratorijsku medicinu (IFCC) je 2002. godine objavila referentnu metodu za HbA1c. Zajedno s metodom definiran je analit i proizveden primarni, specifiÄni referentni materijal. MeÄutim, primjena referentne metode onemoguÄena je znaÄajno nižim rezultatima HbA1c u odnosu na "konvencionalne" metode. Naime, kliniÄke smjernice i standardi utemeljeni su na rezultatu dugogodiÅ”njih istraživanja, gdje se koristila precizna, ali nedovoljno specifiÄna metodologija. MoguÄe snižavanje apsolutnih koncentracija HbA1c, koje bi nastalo uvoÄenjem IFCC-referentnog sustava, predstavlja ozbiljnu prepreku u postizanju i održavanju dobre kontrole Å”eÄerne bolesti. Stoga dijabetoloÅ”ka struka energiÄno inzistira na zadržavanju postojeÄih standarda.
Harmonizacija odreÄivanja HbA1c kljuÄno je pitanje kako individualne skrbi za bolesnike, tako i evaluacije kliniÄkih istraživanja. MeÄutim, njena provedba nužno podrazumijeva kombinaciju analitiÄkih i kliniÄkih standarda. Stoga je predložen "treÄi put", odnosno derivacija novog parametra "prosjeÄne glikemije", koji bi sublimirao analitiÄke prednosti IFCC-referentnog sustava i dragocjene kliniÄke podatke.
Cilj ovog preglednog Älanka jeprikazglobalnog projekta harmonizacije odreÄivanja HbA1c, te predstavljanje aktivnosti poduzetih u tom smislu u Hrvatskoj.Hemoglobin A1c (HbA1c) has been used as a "gold standard" for clinical management of diabetes mellitus for almost 30 years. A good glycemic control, expressed as HbA1c value ā¤7%, today is considered to be a clinical standard for the assessment of both therapeutic efficacy and the risk for development of diabetic complications. It is also a main subject of communication between diabetologists and patients.
Variable and unstandardized methodology, different chemical entities resulting from glycation of the hemoglobin molecule, and a lack of the primary reference material significantly influenced a reliable use of HbA1c in the clinical practice. In 2002, International Federation of Clinical Chemistry and Laboratory Medicine (IFCC) has published a reference method for HbA1c. Together with the method, an analyte has been defined, and a primary, specific reference material has been produced. However, the application of the reference method has been dimmed because of the significantly lower HbA1c values, when compared to "conventional" methods. Clinical guidelines and standards have been based on the results of long-term studies where a precise, but insufficiently specific methodology was used. The possibility of lowering absolute HbA1c values, resulting from IFCC reference method implementation, has been recognized as a serious drawback in attaining and maintaining good metabolic control. Therefore, clinical diabetology has insisted vigorously in keeping existing standards.
Harmonization of HbA1c determination is a key issue of both individual patient care and evaluation of clinical research results. However, a combination of both analytical and clinical standards is implicated in pursuing this goal. Thus, a "third way" has been proposed that offers a derivation of the new parameter "mean blood glucose", representing a sublimation of the analytical advantages offered by IFCC-reference system and valuable clinical data. The aim of this article was to review the global HbA1c harmonization project, and to introduce the respective activities carried out in Croatia
Persons with latent autoimmune diabetes in adults express higher dipeptidyl peptidase-4 activity compared to persons with type 2 and type 1 diabetes
AIMS:
We aimed to determine serum dipeptidyl peptidase-4 (DPP-4) activity in a group of persons with latent autoimmune diabetes in adults (LADA) and to compare it with persons with type 1, type 2 diabetes and healthy controls. -----
METHODS:
DPP-4 activity measurement was performed in 67 persons (21 with type 1, 26 type 2 and 19 with LADA) and 13 healthy age and gender matched controls. -----
RESULTS:
Persons with LADA showed highest DPP-4 activity among the study groups (32.71Ā±3.55 vs 25.37Ā±2.84 vs 18.57Ā±2.54 vs 18.57Ā±2.61U/L p<0.001). Mean glutamic acid autoantibody in persons with LADA was 164.32Ā±86.28IU/mL. It correlated with DPP-4 activity (r=0.484, p=0.013). Furthermore, DPP-4 activity correlated with waist circumference (r=0.279, p=0.034) and glycated haemoglobin A1c (r=0.483, p<0.001), as well as with LDL cholesterol (r=0.854, p<0.001) and total daily insulin dose (r=0.397, p=0.001). In the multinomial regression analysis DPP-4 activity remained associated with both LADA (prevalence ratio 1.058 (1.012-1.287), p=0.001) and type 1 diabetes (prevalence ratio 1.506 (1.335-1.765), p<0.001) while it did not show an association with type 2 diabetes (prevalence ratio 0.942 (0.713-1.988), p=0.564). -----
CONCLUSIONS:
Persons with LADA express higher DPP-4 activity compared to persons with both type 1 and type 2 diabetes. The possible pathophysiological role of DPP-4 in the LADA pathogenesis needs to be further evaluated
Pregnancy outcome and liraglutide levels in serum and umbilical vein blood of a woman with type 2 diabetes. A case report
Background: According to FDA guidelines, liraglutide should be used on the basis of careful consideration in pregnant women with Type 2 diabetes mellitus. The aim of the present study was to record the concentration of liraglutide in maternal and umbilical vein serum from a pregnant woman treated with liraglutide. Case report: The pregnant woman we present in this case report is a 28-year-old diagnosed with Type 2 diabetes mellitus for 7 years. In spite of high insulin dose her glycaemia was poorly controlled, she developed dyslipidaemia and her body weight increased; thus, her diabetologist prescribed liraglutide injections and metformin. At booking, obstetrical ultrasound confirmed intrauterine pregnancy of 8 gestational weeks. The patient was informed about all possible consequences for her foetus that might be caused by liraglutide therapy during pregnancy. She continued her treatment with liraglutide and metformin medication throughout pregnancy. Her pregnancy was terminated by elective Caesarean section at 39 gestational weeks; a healthy newborn male was delivered. The concentration of liraglutide was measured in maternal and umbilical vein serum. Conclusion: There was no significant transfer of liraglutide from the circulation of the treated mother to her fetus, at least 3.5 h after the drug application