Measures of genetic diversity at the allele level for HLA system in a Mexican admixed population.

<p>O.H.: Observed heterozygosity. E.H.: Expected Heterozygosity. <i>p</i> values <0.05 are considered statistically significative and thus reflect differences between O.H. and E.H. PIC: Polymorphism Information Contents. PD: Power of Discrimination.</p

Frequencies of <i>HLA-DRB1-DQB1</i> blocks in 234 Mexican admixed individuals (468 haplotypes).

<p>Blocks of each ancestry (Amerindian, Caucasian, Caucasian shared with other populations, African and Asian) were defined as those found in original populations with H.F. >1,0%, and not found in other native human groups in frequencies higher than 1,0%. We consider <i>t</i> value must be ≥2.0 to denote statistically significant association and thus validate Δ′ (shaded values).^† Similar to DQB1*05∶02 with a silent mutation at codon 133 cgg>cga.</p

Extension of HLA Conserved Extended Haplotypes to <i>HLA-A</i> in 234 Mexican Admixed individuals.

<p>Blocks of each ancestry (Amerindian, Caucasian, Caucasian shared with other populations, African and Asian) were defined as those found in original populations with H.F. >1,0%, and not found in other native human groups in frequencies higher than 1,0%. We consider <i>t</i> value must be ≥2.0 to denote statistically significant association and thus validate Δ′ (shaded values).</p

Principal component analysis (PCA) plot reveals a close genetic relationship of Mexican admixed individuals from Mexico City to Native American groups.

<p>Orange dots refer to African populations. Blue dots represent European samples. Green dots correspond to Asian human groups. Native American populations are represented by purple dots. Red figures are admixed populations from Mexico, with a star locating our Mexico City admixed sample. Proper references of each population group included in the analysis are given in the Materials and Methods section. Ire: Ireland, Eng: England, Ger: Germany, Aus: Austria; Spa: Spain, Ita: Italy, UK: United Kingdom, Fra: France, Gyp: Gypsy, Azo: Azores, Sao: São Tomé Island, Cam: Cameroon, Mal: Mali, Zam: Zambia, KLu: Luo from Kenia, KNa: Nandi from Kenia, Sen: Senegal, Gui: Guinea Bissau, Ale: Aleut from Bering Island, Jap: Japan, Tzu: Taiwan, Han: south China, Ind: north India, Mly: Malasya, Vie: Vietnam, Tar: Tarahumara, Gil: Native Americans from Gila River, Yup: Yu’pik from Alaska, Mit: Mixtec from Oaxaca, Zap: Zapotec from Oaxaca, Mix: Mixe from Oaxaca, Ser: Seri from Sonora, Nav: Navajo from New Mexico, Uro: Uro from Titikaka Lake, Tob: Toba from Rosario, MMM: “Mexican Mestizo” sample, Gua: Guadalajara City, Mex: this study.</p

Frequencies of <i>HLA-C-B</i> blocks in 234 admixed Mexican individuals (468 haplotypes).

<p>Blocks of each ancestry (Amerindian, Caucasian, Caucasian shared with other populations, African, and Asian) were defined as those found in original populations with H.F. >1,0%, and not found in other native human groups in frequencies higher than 1,0%. We consider <i>t</i> value must be ≥2.0 to denote statistically significant association and thus validate Δ′ (shaded values).</p>*<p>Similar to B*35∶01 with a mutation at codon 207 ggc>tgc (Gly>Cys).</p>§<p>Similar to C*03∶04 with a mutation at codon 189 gtg>atg (Val>Met).</p

Allelic frequencies of <i>HLA-A, -B, -C, -DRB1</i>, and <i>-DQB1</i> in 234 Mexicans.

*<p>Similar to B*35∶01 with a mutation at codon 207 ggc>tgc (Gly>Cys).</p>§<p>Similar to C*03∶04 with a mutation at codon 189 gtg>atg (Val>Met).</p>†<p>Similar to DQB1*05∶02 with a silent mutation at codon 133 cgg>cga.</p

HLA Conserved Extended Haplotypes in 234 Mexican admixed individuals (468 haplotypes).

<p>HLA Conserved Extended Haplotypes in 234 Mexican admixed individuals (468 haplotypes).</p