Prevalence of naso-pharyngeal Pneumococcal colonization in children between 1 to 5 years old in pre-school educative centers. 2014-2015

Foundation: Streptococcus pneumoniae is part of the normal bacterial flora of the nasal and pharingeal mucosa. Naso-pharyngeal colonization precedes the pneumococcal disease and affected individuals are a reservoir at the community level.Objective: to determine the prevalence of global naso-pharyngeal colonization and by serotypes of Streptococcus pneumoniae in children of pre-school age before anti pneumoccocal vaccination.Methods: a cross descriptive study in the Cienfuegos Municipality, within the period of June 2014 and April 2015. in children aged between 1 and 5 years attending preschool educative centers (N=1 129). Samples of naso-pharyngeal exudates were taken following the set guidelines. The prevalence of colonization was estimated and the most frequent serotypes were identified.Results: the global prevalence of naso-pharyngeal colonization was 32,32 %. The most frequent vaccine serotypes were 19F (6,02 %) and 6B (3,99 %); of those related with the vaccine, 6A predominated (5,49 %) and of the not related to the vaccine the most frequently observed was 14B.Conclusion: naso-pharyngeal colonization in preschool children not vaccinated against pneumoccocus presented a high prevalence at the expense of the serotypes included in the conjugated anti-peumococcal vaccines.</p

Cost-effectiveness of introducing a domestic pneumococcal conjugate vaccine (PCV7-TT) into the Cuban national immunization programme.

OBJECTIVES: To evaluate the cost-effectiveness of introducing a domestic pneumococcal conjugate vaccine (PCV7-TT) into the Cuban National Immunization Program (NIP). METHODS: We compared PCV7-TT given at two, four and six months of age to a scenario without PCV7-TT, over a ten-year period (2020-2029). We calculated the cost (Cuban pesos - CUP) per Disability Adjusted Life Year (DALY) averted from a Government perspective. We compared results from a static cohort model and a parsimonious prediction model informed by the serotype distribution among pneumococcal carriers and cases. We ran probabilistic and deterministic uncertainty analyses. RESULTS: PCV7-TT could prevent 6897 (95% uncertainty interval, 4344-8750) hospitalizations and 189 (115-253) deaths in children <5 years of age, over the period 2020-2029. This could cost around 25 million (20-31) discounted CUP but would be offset by treatment cost savings of around 23 million (14-31). A parsimonious model predicted less favourable impact and cost-effectiveness but the cost per DALY averted was still less than 0.4 times the current GDP per capita. CONCLUSIONS: PCV7-TT is likely to be cost-effective in Cuba. The impact of the vaccine would need to be carefully monitored following its introduction into the NIP

Corrigendum to "Cost-effectiveness of introducing a domestic pneumococcal conjugate vaccine (PCV7-TT) into the Cuban national immunization programme" [Int. J. Infect. Dis. 97 (2020) 182-189].

The authors regret that the Methods section has error in the formula. Corrections follow. In the Modelling approach section… For a given week (w) of age, the number of disease events Dw was calculated as: [Figure presented] where: P × S × Aw is the number of disease events in week w of age; Vw is the effect of vaccination in week w of age; P is the number of person-years lived between birth and age 5.0 years in the birth cohort evaluated; S is the streptococcus pneumoniae (pneumococcal) disease event rate per 100,000 per year among children younger than 5 years before the introduction of vaccination; and Aw is the proportion of pneumococcal disease events in children younger than 5 years in week w of age. In the Pneumococcal disease burden inputs section… For each birth cohort, estimates of person-years lived between birth and age 5.0 years (P) were based on United Nations demographic projections (https://population.un.org/wpp/). We estimated disease event rates (S) separately for pneumococcal acute otitis media (AOM), non-severe pneumococcal pneumonia, severe pneumococcal pneumonia, pneumococcal meningitis and other non-pneumonia/non-meningitis pneumococcal disease (NPNM) (Table 1). The authors would like to apologise for any inconvenience caused

Low-Cost Materials for Do-It-Yourself (DIY) Installation of House Screening against <em>Aedes aegypti</em>

House-screening (HS) using fixed-aluminium frames to reduce the risk of indoor infestation with Aedes aegypti mosquitoes as well as the risk of Aedes-transmitted diseases in communities living in endemic areas. However, the success of this approach has been hindered by the elevated cost of the aluminium-based materials as well as their professional installation, which cannot be afforded by people living under vulnerable conditions. Cost-saving strategies such as the use of low-cost materials including wood, PVC, and Velcro are within the list of HS options available and offered by HS businesses and/or Do-it-yourself (DIY) packages verbi gratia ready-made and ready-to-install mosquito-screens. Here, we evaluated the efficacy of low-cost frames constructed with different materials to protect against Ae. aegypti indoor infestation using experimental huts. The efficacy of protection in preventing female mosquito passing inside the huts of any of the options of frames was high (>93%) compared to the control with no-screen. People’s perceptions on the different materials showed the most “popular” alternative was the frame made of wood (62%). All the prototype-frames of HS made of different materials were effective at blocking Ae. aegypti entering-mosquitoes particularly, low-cost options like magnets and Velcro

Serotypes and antimicrobial resistance of Streptococcus pneumoniae in Chinese pediatric population: a scoping review

This review aimed to explore the serotype distribution and antimicrobial resistance of Streptococcus pneumoniae in the Chinese pediatric population based on literature published in the last six years. A scoping review was performed using PubMed and two Chinese databases: CNKI and WanFang Data. Of the total of 196 articles extracted, 14 studies were selected for this review. There are 13 articles that analyze the distribution of Streptococcus pneumoniae serotypes, the most frequently registered serotypes are: 19F, 19A, 23F, 14 and 6B. There are 11 articles that analyze the antimicrobial resistance of Streptococcus pneumoniae, the prevalence of non-susceptible to penicillin is in the range of 0% to 95.7%. Isolates are highly resistant to erythromycin, clindamycin, tetracycline, and trimethoprim-sulfamethoxazole; they are resistant to penicillin in pneumococcal meningitis but are sensitive to penicillin in other pneumococcal diseases, in addition, they are very sensitive to levofloxacin, vancomycin and Linezolid. It is concluded that the pneumococcal conjugate vaccine 13 has high coverage in Streptococcus pneumoniae serotypes in children from mainland China, therefore its inclusion in the childhood vaccination program is recommended; at the same time, the occurrence of serotype substitution should be taken into account. Therefore, more pediatric patients or children should be included in research, especially those under five years of age. Long-term, high-quality surveillance of the serotype distribution and antimicrobial resistance of Streptococcus pneumoniae is necessary for the development of pneumococcal disease prevention

La globalización y el modelo de Medicina General Integral en Cuba: Retos y oportunidades

En este trabajo, tomando como base sus conocimientos y la literatura disponible, se expone una sinopsis de la esencia de la práctica médica contemporánea en el hemisferio occidental y la situación de la salud en el mundo actual. Se ven ambas situaciones como el resultado de los avances del proceso de globalización en estos últimos años. Al relacionarlas con la situación sanitaria de Cuba, surgen importantes respuestas e interrogantes frente al fundamental desarrollo diferenciado del sistema de salud cubano basado en la práctica de la Medicina General Integral en la atención primaria de salud. En esta situación de retos y también de oportunidades, nuestro modelo de desarrollo sanitario puede servir de paradigma a muchos países y a las personas que en todo el mundo están buscando nuevas orientaciones para hacer frente a los efectos de la globalización; por eso los autores se plantean seguir el necesario perfeccionamiento de las políticas, programas y acciones que logren, a través de la máxima cohesión de nuestras fuerzas, los más altos niveles posibles de desarrollo humano fundamentado en los valores de la equidad, sustentabilidad y democracia; tal como nos lo imponen nuestras aspiraciones sociales<br>In this paper, taking as a basis their knowledge and the literature available, the authors make a synopsis of the essence of contemporary practical medicine in the western hemisphere and of the present situation of medicine in the world. Both problems are seen as the result of the advances of the process of globalization in the last years. On comparing them with the health status in Cuba, important questions and answers appear in the face of the fundamental differentiated development of the Cuban health system based on the practice of Comprehensive General Medicine at the primary health care level. In this situation of challenges and opportunities, our model of health development may serve as a paradigm for many countries and persons that all over the world are looking for new options to face the effects of globalization. That´s why the authors recommend to go on with the necessary improvement of policies, programs and actions that attain, through the maximum cohesion of our forces, the highest possible levels of human development based on the values of equity, sustenance and democracy in accordance with our social aspiration

Un ejemplo de plan temático para investigaciones operacionales aplicadas a la Atención Primaria de Salud

Se expone el Plan Temático que el Instituto de Medicina Tropical "Pedro Kourí" se propone para los próximos años y los grandes retos a enfrentar, así como la experiencia que ya acumulan sus profesionales como aval de éxito para estas intervenciones. El trabajo fundamenta la necesidad muy importante de continuar el perfeccionamiento de nuestro sistema de atención primaria de salud (APS). Se reconoce a nuestra APS como un modelo único en el mundo, y al mismo tiempo novedoso y complejo. Se plantea que la aplicación del enfoque epidemiológico a la APS puede ayudar mucho a mejorar la ejecución de los actores sociales que en ella intervienen, y por ende, mejorar el rendimiento del modelo en beneficio de la salud de la comunidad.The Thematic Plan proposed by "Pedro Kouri" Institute of Tropical Medicine for the next years, as well as the great challenges to be faced are explained in this paper. Emphasis is made on the experience accumulated by its professionals as a guarantee for the success of these interventions. The paper establishes that it is very necessary to continue improving our primary health care (PHC) system, which is recognized as a novel, complex and unique model in the world. It is stated that the application of the epidemiological approach to PHC may help to enhance the performance of the social actors that take part in it, and to make better the efficiency of the model for the benefit of community health

Participación comunitaria en la prevención del dengue: un abordaje desde la perspectiva de los diferentes actores sociales Community participation in dengue prevention: an approach from the perspective of different social actors

OBJETIVO: explorar las percepciones sobre la participación comunitaria en la prevención del dengue durante la investigación formativa de un proyecto comunitario. MATERIAL Y MÉTODOS: Estudio conducido en tres áreas de salud de Santiago de Cuba durante el año 2000. Se combinan técnicas cualitativas y cuantitativas para explorar opiniones de los profesionales de salud, líderes comunitarios y una muestra aleatoria de población. RESULTADOS: Los profesionales identifican la no participación de la comunidad y sus propias limitaciones para involucrarla activamente en la prevención. Los líderes refieren falta de motivación, y la población vincula la eliminación del vector con el uso de tecnologías. Se perciben barreras en la aceptación de las actividades del programa de control y en general la "participación" es interpretada como "colaboración". CONCLUSIONES: La población ha trasferido responsabilidad del control del Aedes aegypti al sector salud. Se evidencia la necesidad de unificar conceptos sobre la participación comunitaria y conciliar intereses entre usuarios y proveedores de los servicios para lograr una real movilización social.<br>OBJECTIVE:To explore the perceptions about community participation in dengue fever control during formative research for a community project. MATERIAL AND METHODS: This study was conducted in three health areas of the Santiago de Cuba municipality during the year 2000. Qualitative and quantitative techniques were used to explore the opinions of health professionals, community leaders and a random sample of 200 people living in the community. Results. The health professionals who were interviewed judged that difficulties in Aedes aegypti control were due to lack of participation of the community and to limited knowledge of prevention methods. Community leaders considered that the population was poorly motivated. The randomly selected subjects who were interviewed did associate Aedes control with technological intervention. The authors identified barriers to acceptance of control program activities. In general, the concept of "participation" was interpreted as "collaboration". CONCLUSIONS: Our findings show that the community has transferred the responsibility for Aedes aegypti control to the health sector. There is an evident need for unifying the concepts of community participation, as well as for matching the interests of users and health care providers, in order to attain a significant social mobilization

Participación comunitaria en la prevención del dengue: un abordaje desde la perspectiva de los diferentes actores sociales

OBJETIVO: explorar las percepciones sobre la participación comunitaria en la prevención del dengue durante la investigación formativa de un proyecto comunitario. MATERIAL Y MÉTODOS: Estudio conducido en tres áreas de salud de Santiago de Cuba durante el año 2000. Se combinan técnicas cualitativas y cuantitativas para explorar opiniones de los profesionales de salud, líderes comunitarios y una muestra aleatoria de población. RESULTADOS: Los profesionales identifican la no participación de la comunidad y sus propias limitaciones para involucrarla activamente en la prevención. Los líderes refieren falta de motivación, y la población vincula la eliminación del vector con el uso de tecnologías. Se perciben barreras en la aceptación de las actividades del programa de control y en general la "participación" es interpretada como "colaboración". CONCLUSIONES: La población ha trasferido responsabilidad del control del Aedes aegypti al sector salud. Se evidencia la necesidad de unificar conceptos sobre la participación comunitaria y conciliar intereses entre usuarios y proveedores de los servicios para lograr una real movilización social