The Effect of One Period of Progressive Resistance Training on Plasma Levels of Omentin-1, Insulin Resistance, Non-high Density Lipoprotein and Some cardiovascular Risk Factors in Men

Background and Objectives: Adipose tissue as an endocrine gland produces a large number of intermediate compounds that are involved in many metabolic processes. Omentin-1 as a beneficial adipokine, has attracted more attention from researchers due to its favorable effects on inflammation, glucose homeostasis, and prevention of cardiovascular disease (CVD). The aim of this study was to investigate the effect of 8 weeks of progressive resistance training on plasma levels ofomentin-1, insulin resistance, non-high density lipoprotein (non-HDL), and some cardiovascular risk factors in overweight and obese men. Methods :In this quasi-experimental study, 20 healthy overweight and obese male subjects (22.75&plusmn;1.29 years, 89.22&plusmn;13.08kg, 28.36&plusmn;3.98kg/m&sup2;), were selected as available subjects and randomly assigned to training (n=10) and control (n=10) groups. Exercise protocol included 8 weeks of resistance training (4 sessions/week, 60min/session). Blood samples were taken before and after the exercise to evaluate blood variables. Plasma omentin-1 level was measured using ELISA method. Data were analyzed by paired and independent t-tests at the significance level of p<0.05. Results: After 8 weeks of resistance training in the experimental group, the level of serum omentin-1 insignificantly increased (p=0.79), and the levels of non-HDL-c (p=0.024), TG (p=0.017), TC (p=0.032), and systolic blood pressure (p=0.002) significantly decreased. There were no significant changes in other variables. Conclusion: The results of this study showed that 8 weeks of resistance training, in spite of positive effect on some cardiovascular risk factors (non-HDL-c, triglyceride, total cholesterol), had no significant effect on omentin-1 and insulin resistance

Investigation of gene expression and serum levels of PIN1 and eNOS with high blood pressure in patients with Alzheimer disease

WOS: 000408297700013PubMed ID: 28506742According to evidence, Alzheimer's disease is known as one of the most serious neurodegenerative diseases, for which hypertension has been observed to be a key risk factor. Therefore, this study aims to examine the relationship between the PIN1 and eNOS genes expression, as well as serum levels and hypertension in Alzheimer's disease sufferers. Blood samples were obtained from subjects who were divided into four groups: the control group, normotensive Alzheimer's patients, the Alzheimer's sufferers group with hypertension, and the healthy group with only hypertension, considering the inhibition of confounding factors. Thereafter, eNOS and PIN1 genes expression along with serum levels were studied. Based on the obtained results, a statistically significant correlation didn't exist between serum level of PIN1 and the systolic and diastolic blood pressure, between serum level of eNOS and diastolic blood pressure in the norm tension Alzheimer's disease patients, between serum levels of PIN1, eNOS and systolic blood pressure, and between serum eNOS and systolic and diastolic blood pressure in the patients with hypertension (p < 0.05). According to the results obtained from this study, measuring the serum levels of eNOS and Pint may contribute to the prognosis, prevention, and monitoring of hypertension and also to the reduction of death rates from cardiovascular diseases in Alzheimer's disease. (C) 2017 Elsevier Ltd. All rights reserved.Neuroscience Research Center (NSRC), Tabriz University of Medical Sciences, Tabriz, IranThis research has been supported by Neuroscience Research Center (NSRC), Tabriz University of Medical Sciences, Tabriz, Iran