SYNTHESIS AND EVALUATION OF ANTITUBERCULAR AND ANTI FUNGAL ACTIVITY OF SOME NOVEL 6-(4-SUBSTITUTED ARYL)-2-(3,5-DIMETHYL-1H-PYRAZOL-1-YL) IMIDAZO[2,1-B] [1,3,4] THIADIAZOLE DERIVATIVES

ABSTRACT The 6-(4-substituted aryl)-2-(3,5-dimethyl-1H-pyrazol-1-yl)imidazo[2,1-b][1,3,4]thiadiazole (2a to f) were prepared by treating 2-amino-5-(3,5-dimethyl-H-pyrazole-1yl)-1,3,4-thiadiazole with appropriate α-haloaryl ketones. The reaction 2 with morpholine using formaldehyde, acetic acid in methanol yielded the corresponding 5- morpholin-4-ylmethyl derivatives (3a-e). While compound 2 also produces the 5- pyrrolidine-4-ylmethyl derivatives (4a-e) by reaction with pyrrolidine using formaldehyde, acetic acid in methanol. The 5- piperidin-4-ylmethyl derivatives (5a-e) were obtained by treating compound 2 with piperidine using formaldehyde, acetic acid in methanol. The structures of the newly synthesized compounds confirmed by IR, NMR and Mass spectra. All the compounds were screened for antitubercular and antifungal activity. Some of the compound displayed very good antitubercular and antifungal activity. Keywords: 2-Amino-5-(3,5-dimethyl-H-pyrazole-1yl)-1,3,4-thiadiazole; Imidazo[2,1-b][1,3,4] thiadiazole; Antitubercular activity; Antifungal activity

Organ Transplantation, Pros, Cons, and illustrations: A Basic Awareness to the Public

Solid-organ transplantation saves the lives of patients affected by end-stage organ failure and enhances the quality of life. It has been developed in the last two decades and provides amazing results for children and young people and increases the growing number of elderly transplant patients with organ transplantation. Use of corticosteroids, vaccines, and other drugs to avoid infection in diseased patients. Several approaches have been developed to prolong organ obtainability, including living donor liver transplantation, split liver transplantation, and application of expanded criteria for donors and donation after circulatory death grafts. Unprincipled practices in many countries are due to the availability of organs. Organ transplantation requires screening and comparative contraindications in the recipient. The authors want to give a general awareness to the public, which is essential to know for donating and receiving organs from others