221 research outputs found
Complement activation correlates with graft damage in baboon-to-human liver xenotransplantation
Posttransplant B, non-A non-B, and cytomegalovirus hepatitis increase the risk of developing chronic rejection after liver transplantation
Temporary withdrawal of immunosuppression for life-threatening infections after liver transplantation
IgG lymphocytotoxic antibodies in clinical liver transplantation: Studies toward further defining their significance
Vascularized bone marrow transplantation in rats: Evidence for amplification of hematolymphoid chimerism and freedom from graft-versus-host reaction
The spectrum of aspergillosis in liver transplant patients: Comparison of FK 506 and cyclosporine immunosuppression
Human liver xenotransplantation
During the past 30 years orthotopic liver transplantation has become a highly successful form of surgical treatments. The significant advances achieved in this field have led to an increased demand for organs and created a wide gap between organ availability and organ supply. A wider availability of organs for transplantation would allow an expansions rather than a contraction of the indications for transplantation, and, at the same time a relaxation of the patient selection criteria. All these facts clearly justify the renewed interest observed in the last decade in xenotransplantation. The original concept of xenografting, meaning the transplantation of cells, tissues, or organs between different species, is so ancient that it is easily recognizable in Greek and Roman mythology. The centaur Chiron, the teacher of Esculapius, and the Chimera are legendary examples of discordant xenogeneic creatures. However, it is only during this century that scientists have been able to bring this idea into the clinical arena. The early efforts were prompted by the shortage of humans organs at a time when there were few alternatives for treating end-stage organ failure
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