Microscopic theory of quantum dot interactions with quantum light: local field effect

A theory of both linear and nonlinear electromagnetic response of a single QD exposed to quantum light, accounting the depolarization induced local--field has been developed. Based on the microscopic Hamiltonian accounting for the electron--hole exchange interaction, an effective two--body Hamiltonian has been derived and expressed in terms of the incident electric field, with a separate term describing the QD depolarization. The quantum equations of motion have been formulated and solved with the Hamiltonian for various types of the QD excitation, such as Fock qubit, coherent fields, vacuum state of electromagnetic field and light with arbitrary photonic state distribution. For a QD exposed to coherent light, we predict the appearance of two oscillatory regimes in the Rabi effect separated by the bifurcation. In the first regime, the standard collapse--revivals phenomenon do not reveal itself and the QD population inversion is found to be negative, while in the second one, the collapse--revivals picture is found to be strongly distorted as compared with that predicted by the standard Jaynes-Cummings model. %The model developed can easily be extended to %%electromagnetic excitation. For the case of QD interaction with arbitrary quantum light state in the linear regime, it has been shown that the local field induce a fine structure of the absorbtion spectrum. Instead of a single line with frequency corresponding to which the exciton transition frequency, a duplet is appeared with one component shifted by the amount of the local field coupling parameter. It has been demonstrated the strong light--mater coupling regime arises in the weak-field limit. A physical interpretation of the predicted effects has been proposed.Comment: 14 pages, 7 figure

Knowledge and innovation dynamics of the Northwest Russia under geopolitical changes

Over the past 25 years, Russia has faced several economic and geopolitical challenges, including the 2008 global financial crisis, sanctions imposed in 2014, and the COVID-19 pandemic. To remain resilient in the face of these challenges, Russia needs to adopt a flexible development strategy and transition to a new path of development. This transition requires the development of new knowledge-intensive industries, expansion into promising markets, strengthening trade and economic partnerships, and achieving technological sovereignty. This study examines the innovation system in Northwest Russia and identifies factors that are critical for its sustainability and innovation security in the face of geopolitical instability. The study uses an integrated approach to trace the knowledge production and innovation process from research findings to the commercialization of new technologies. The study finds that there are strong correlations between innovation activity and R&D investment, patent activity, and the number of innovative organisations. The study also identifies three types of regional innovation systems in Northwest Russia: core, semi-periphery, and periphery. The nature of the regions' involvement in R&D determines the dynamics and specialization of their publications and patents. The study also finds that there is a positive correlation between the volume of innovative products and quantitative factors in the functioning of subsystems involved in knowledge generation and innovation. Finally, the study examines the geography and structure of the international research network that the regions of Northwest Russia had formed by 2022. It shows that the geopolitical transformation requires a significant part of cooperation ties with unfriendly countries to be restructured

Efficient chemotherapy of rat glioblastoma using Doxorubicin-loaded PLGA nanoparticles with different stabilizers

Background: Chemotherapy of glioblastoma is largely ineffective as the blood-brain barrier (BBB) prevents entry of most anticancer agents into the brain. For an efficient treatment of glioblastomas it is necessary to deliver anti-cancer drugs across the intact BBB. Poly(lactic-co-glycolic acid) (PLGA) nanoparticles coated with poloxamer 188 hold great promise as drug carriers for brain delivery after their intravenous injection. In the present study the anti-tumour efficacy of the surfactant-coated doxorubicin-loaded PLGA nanoparticles against rat glioblastoma 101/8 was investigated using histological and immunohistochemical methods. Methodology: The particles were prepared by a high-pressure solvent evaporation technique using 1% polyvinylalcohol (PLGA/PVA) or human serum albumin (PLGA/HSA) as stabilizers. Additionally, lecithin-containing PLGA/HSA particles (Dox-Lecithin-PLGA/HSA) were prepared. For evaluation of the antitumour efficacy the glioblastoma-bearing rats were treated intravenously with the doxorubicin-loaded nanoparticles coated with poloxamer 188 using the following treatment regimen: 3×2.5 mg/kg on day 2, 5 and 8 after tumour implantation; doxorubicin and poloxamer 188 solutions were used as controls. On day 18, the rats were sacrificed and the antitumour effect was determined by measurement of tumour size, necrotic areas, proliferation index, and expression of GFAP and VEGF as well as Isolectin B4, a marker for the vessel density. Conclusion: The results reveal a considerable anti-tumour effect of the doxorubicin-loaded nanoparticles. The overall best results were observed for Dox-Lecithin-PLGA/HSA. These data demonstrate that the poloxamer 188-coated PLGA nanoparticles enable delivery of doxorubicin across the blood-brain barrier in the therapeutically effective concentrations