52 research outputs found

    Half a century of amyloids: past, present and future

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    Amyloid diseases are global epidemics with profound health, social and economic implications and yet remain without a cure. This dire situation calls for research into the origin and pathological manifestations of amyloidosis to stimulate continued development of new therapeutics. In basic science and engineering, the cross-ß architecture has been a constant thread underlying the structural characteristics of pathological and functional amyloids, and realizing that amyloid structures can be both pathological and functional in nature has fuelled innovations in artificial amyloids, whose use today ranges from water purification to 3D printing. At the conclusion of a half century since Eanes and Glenner's seminal study of amyloids in humans, this review commemorates the occasion by documenting the major milestones in amyloid research to date, from the perspectives of structural biology, biophysics, medicine, microbiology, engineering and nanotechnology. We also discuss new challenges and opportunities to drive this interdisciplinary field moving forward. This journal i

    Sustainable irrigation development

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    In Wijayaratna, C. M. (Ed.). Asian Productivity Organization (APO) Seminar on Linking Main System Management for Improved Irrigation Management, Colombo, Sri Lanka, 3-8 June 2002. Tokyo, Japan: Asian Productivity Organization (APO).This paper explores the issues that face irrigation in the future, drawing on recent experiences in Asia and elsewhere to illustrate some cases where interventions have fallen short of sustainable development targets. The paper argues that sustainable development is often misinterpreted and that incremental development is a more realistic model to achieve the objectives of sustainability and poverty alleviation. In the paper the focus is on irrigation as a means of achieving food security. However, effective utilization of water to achieve high productivity is a major objective, and this is now widely recognized to include enhanced rainfed agriculture and agricultural system. Therefore, the boundaries between rainfed and irrigated agriculture are becoming increasingly blurred requiring practitioners in agricultural development to have a broader perspective. The use of sustainable livelihood concepts has also changed the development canvas by bringing the analysis of the entire socioeconomic setting into focus

    Sustainable intensification of agriculture with sustainable irrigated agroecosystem services

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    Irrigated agriculture is undeniably a significant modification to natural ecosystems, and one which has not been without significant adverse impacts on the ecology and hydrology of the landscapes and river basins in which irrigation systems are located. A lack of consideration for broader ecosystem service values during planning, implementation and subsequent operation of irrigation projects may explain the underperformance of investments in irrigation systems. In many cases, this has arisen because irrigation schemes have been designed for a single purpose (intensification or increase) of agricultural production without due consideration being given to other ecosystem functions, and in isolation from the landscape of the entire catchment. Large-scale irrigation systems (LSIS) and smaller, often community managed, systems have been a central component in the food security of the population in much of Asia3, and these systems are expected to make increased contributions to food security and improved livelihoods in sub-Saharan Africa (SSA). Irrigation has been an essential input to agriculture to meet the fast-increasing demand for food and is also a contributor to poverty reduction. Future population growth and economic development means that the increasing demand for food must be expected to continue, and it is projected that intensified irrigated agriculture will have to provide about 60% of the extra food needed (World Bank, 2007). Yet, the expansion of irrigated areas has slowed, rates of productivity improvement are slowing, and water availability for irrigation is being constrained by alternate demands for water. Simultaneously, concerns over loss of biodiversity and disruption of ecosystems have increased, resulting in the increasing examination of the sustainability of agricultural value chains and the role of agriculture in the landscape. The core objective of the CGIAR Research Program on Water, Land and Ecosystems (WLE), led by the International Water Management Institute (IWMI), is to promote the sustainable intensification of agriculture through evidence-based research and policy development. Fundamental to the achievement of this goal is the application and uptake of an ecosystem services and resilience-based approach. This paper presents an ecosystem service-based approach to sustainable intensification of irrigated agriculture, highlighting approaches to guide research, policy development and strategies to stimulate ecosystem-inclusive management of irrigated agriculture. The concepts of ecosystem services are reasonably well established. However, attempts to develop ecosystem-inclusive management of LSIS is new

    Modernizing irrigation operations: spatially differentiated resource allocations

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    Presents an improved methodology for evaluating the resource demands necessary for effective canal operations. Includes identification and analysis of three operational domains: vulnerability, sensitivity and perturbation. Enables more cost-effective strategies and procedures for operation, and priorities for rehabilitation or modernization of physical infrastructure
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