Towards more integrated natural resource management in Victoria : possible elements of an integrated state-wide policy framework

There is a growing recognition of the complexity of environmental issues and acceptance of the value of more integrated approaches to address them. Evidence of progress with the development of more integrated approaches is however less clear cut. Within this context, this paper explores how a more integrated approach 10 natural resource management at a state government level could be progressed. Using recent experience in Victoria as a focus, this paper provides an overview of environment and natural resources issues confronting the State. highlights why integration is an important element of any response. and outlines the current policy and organisational context. Possible elements of a state-wide policy framework for more integrated natural resource management across a state government organisation are also outlined and discussed.<br /

Interoperable geographically distributed astronomical infrastructures: technical solutions

The increase of astronomical data produced by a new generation of observational tools poses the need to distribute data and to bring computation close to the data. Trying to answer this need, we set up a federated data and computing infrastructure involving an international cloud facility, EGI federated, and a set of services implementing IVOA standards and recommendations for authentication, data sharing and resource access. In this paper we describe technical problems faced, specifically we show the designing, technological and architectural solutions adopted. We depict our technological overall solution to bring data close to computation resources. Besides the adopted solutions, we propose some points for an open discussion on authentication and authorization mechanisms.Comment: 4 pages, 1 figure, submitted to Astronomical Society of the Pacific (ASP

Concert Choir Madrigal Singers Chamber Orchestra

St John\u27s Lutheran Church Bloomington, IL February 27, 2000 3:00p.m

Building an interoperable, distributed storage and authorization system

A joint project between the Canadian Astronomy Data Center of the National Research Council Canada, and the italian Istituto Nazionale di Astrofisica-Osservatorio Astronomico di Trieste (INAF-OATs), partially funded by the EGI-Engage H2020 European Project, is devoted to deploy an integrated infrastructure, based on the International Virtual Observatory Alliance (IVOA) standards, to access and exploit astronomical data. Currently CADC-CANFAR provides scientists with an access, storage and computation facility, based on software libraries implementing a set of standards developed by the International Virtual Observatory Alliance (IVOA). The deployment of a twin infrastructure, basically built on the same open source software libraries, has been started at INAF-OATs. This new infrastructure now provides users with an Access Control Service and a Storage Service. The final goal of the ongoing project is to build an integrated infrastructure geographycally distributed providing complete interoperability, both in users access control and data sharing. This paper describes the target infrastructure, the main user requirements covered, the technical choices and the implemented solutions

Building an Interoperable, Distributed Storage and Authorization System

A joint project between the Canadian Astronomy Data Centre (CADC) of the Canadian National Research Council, and the Italian Istituto Nazionale di Astrofisica-Osservatorio Astronomico di Trieste (INAF-OATs), partially funded by the EGI-Engage H2020 European Project, is devoted to deploy an integrated infrastructure to access and exploit astronomical data. This infrastructure will be entirely based on the International Virtual Observatory Alliance (IVOA) standards, see IVOA (2016). Currently CADC-CANFAR provides scientists with an access, storage and computation facility based on software libraries implementing a set of standards and recommendations developed by the International Virtual Observatory Alliance (IVOA). The deployment of a twin infrastructure, basically built on the same open source software libraries, has been started at INAF-OATs. Currently, this new infrastructure provides users with an Access Control Service and a Storage Service. The final goal of the ongoing project is to build an integrated infrastructure providing complete interoperability between the two described geographically distributed infrastructures, both in users access control and data sharing. This paper describes the target infrastructure, the main user requirements covered, the technical choices and implemented solutions

Medical Encounter Characteristics of HIV Seroconverters in the US Army and Air Force, 2000–2004

BACKGROUND AND METHODS: Active duty US Army and Air Force military personnel undergo mandatory biennial HIV antibody screening. We compared pre- and post-HIV seroconversion health status by conducting a case-control study, which evaluated all medical encounters and sociodemographic factors among incident HIV seroconverters and HIV-negative controls from June 2000 through February 2004. RESULTS: A total of 274 HIV seroconverters and 6205 HIV-negative personnel were included. In multivariate analysis restricted to male personnel (cases = 261, controls = 5801), single marital status (adjusted odds ratio [AOR] = 14.37), clinical indicators or symptoms within four years of HIV diagnosis (AOR = 6.22), black race (AOR = 5.88), nonindicator clinical syndromes within 2 years of HIV diagnosis (AOR = 3.31), any mental disorder within 4 years of HIV diagnosis (AOR = 3.04), increasing service-connected time (AOR = 1.69), and older age (AOR = 1.12) were associated with HIV diagnosis among males. A prior history of a sexually transmitted infection (STI) was associated with post-HIV seroconversion STI (OR(M-H) = 4.10). Similarly, a prior history of mental disorder was associated with post-HIV seroconversion mental disorder (OR(M-H) = 4.98). Forty-seven (18%) male cases were hospitalized at least once after HIV diagnosis; infectious diseases, and mental disorders made up 53% of initial admissions. CONCLUSIONS: HIV seroconversion was associated with increased health care-seeking behavior, STIs, and mental disorders, some of which may be amenable to screening. The higher STI rate after HIV diagnosis may partially be a consequence of monitoring, but secondary transmission of STI and possibly HIV require further definition and subsequent tailored preventive interventions

Group Membership Service Version 1.0

The Group Membership Service (GMS) specification describes a service interface for determining whether a user is a member of a group. Membership information can be used to protect access to proprietary resources. When an authorization decision is needed (whether to grant or deny access to a proprietary resource), a call to GMS can be made to see if the requesting user is a member of the group assigned to protect the resource in question. Examples of proprietary resources are wide ranging but include: observation data and metadata and scarce or limited services and infrastructure. Because this specification details how a single group can protect multiple, potentially distributed, resources, it allows for the representation of teams with common authorization rights. The members of such teams can span multiple organizations but can be managed within a single service. In this way, GMS offers an interoperable, flexible, and scalable mechanism for sharing proprietary assets with a potentially dynamic set of team members

Engineering a genetically encoded competitive inhibitor of the KEAP1–NRF2 interaction via structure-based design and phage display

In its basal state, KEAP1 binds the transcription factor NRF2 (Kd = 5 nM) and promotes its degradation by ubiquitylation. Changes in the redox environment lead to modification of key cysteines within KEAP1, resulting in NRF2 protein accumulation and the transcription of genes important for restoring the cellular redox state. Using phage display and a computational loop grafting protocol, we engineered a monobody (R1) that is a potent competitive inhibitor of the KEAP1–NRF2 interaction. R1 bound to KEAP1 with a Kd of 300 pM and in human cells freed NRF2 from KEAP1 resulting in activation of the NRF2 promoter. Unlike cysteine-reactive small molecules that lack protein specificity, R1 is a genetically encoded, reversible inhibitor designed specifically for KEAP1. R1 should prove useful for studying the role of the KEAP1–NRF2 interaction in several disease states. The structure-based phage display strategy employed here is a general approach for engineering high-affinity binders that compete with naturally occurring interactions

USP6 oncogene promotes Wnt signaling by deubiquitylating Frizzleds

Ubiquitin-specific protease 6 (USP6) is a deubiquitylase that is overexpressed by chromosome translocation in two human neoplasms, aneurysmal bone cyst and nodular fasciitis. The relevant substrates of this ubiquitin-specific protease are not clear. Here, we identify the Wnt receptor Frizzled (Fzd) as a key target of the USP6 oncogene. Increased expression of USP6 increases the membrane abundance of Fzd, and hence increases cellular sensitivity to Wnts. USP6 opposes the activity of the ubiquitin ligase and tumor suppressor ring finger protein 43 (RNF43). This study identifies a new mechanism for pathological Wnt pathway activation in human disease and suggests a new approach to regulate Wnt activity therapeutically