Biodiversité des rivières méditerranéennes : indicateur, outil et objectifs de gestion.

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La tournée forêt méditerranéenne en Corse

Décrit successivement : la forêt de chênes verts de la vallée du Fango, les différents étages de végétation de Porto à Corte, la gestion forestière en site classé (Restonica), l'agrosylvopastoralisme (SIVOM Venaco), la chaufferie de Corte, la sylviculture en forêt de Ghisoni, et les lotissements en bois de Sperone

Organic farming to preserve water quality?Comparison of three emblematic cases of successful management of drinking water catchment area

Protecting water resources from pollutants generated by agricultural activities is becoming more strictly regulated in Europe today, with an obligation to achieveresults. This means that towns willing to improve quality of their domestic water supply are required to regulate farmers’ practices in the water catchment areas. In this paper, we studied three cases (Munich and Augsburg in Germany, and Lons-le-Saunier in France) often listed as successful initiatives/ experiences of preservation of water quality by local authorities that have developed coordination with farmers. In this paper, we carried out a comparative analysis of the construction of city-farmer agreements, based on in-depth surveys and with a particular focus on the role of conversion to organic farming in these agreements. We highlighted several significant differences between these three case studies, with regard to the delimitation of the city’s field of action, the nature of compensation proposed to the farmers, the direct involvement of the city council in the acquisition of land in the vulnerable zone, and the importance granted to organic farming. However, in all three cases we also found similarities, such as the importance, for successful city-farmer coordination, of a facilitator as an intermediary between the two parties, as well as dialogue and contracts that span sufficiently long periods. When these conditions are met, which is the case in the two German cities, the results on the water quality are positive. From this point of view, the German water utilities’ status as “private companies owned by the city” seems to be highly conducive to the introduction of truly environment-friendly practices by farmers. In contrast, in the French case, the greater weight of regulatory constraints on the establishment of direct relations with farmers tends to prevent any fluidity in modes of action and to trigger tensions. Finally, the specific study of the role of conversion to organic farming in the solutions proposed and accepted by the farmers highlights a number of factors needed for the territorial development of this typeof farming: a strong political will that translates into high financial incentives, guaranteed local markets for organic products, and necessary technical support. These factors nevertheless remain insufficient in two of the three case studies, and only the city of Munich, starting off with a particularly favourable situation, has been able to achieve a territorial development of organic farming in tandem with the preservation of its water resources

Towards sustainable agricultural landscapes: Lessons from an interdisciplinary research-based framework applied to the Saint Lawrence floodplain

Abstract Floodplains are unique environments that provide a dynamic link between terrestrial and aquatic systems. Intensification of human activity – particularly agriculture and urbanisation – has resulted in the degradation of floodplains worldwide. Restoration and sustainable management of floodplains requires holistic assessment and compromise between stakeholders to successfully balance environmental, economic, and social benefits. Yet, understanding these complex systems sufficiently to provide evidence-based recommendations is a challenge. We present the lessons learned from establishing an interdisciplinary research-based framework on the agricultural floodplain of Lake Saint Pierre, Québec, Canada, whose mandate was to a) understand and define key environmental, agricultural, and socioeconomic attributes of the landscape, b) quantify the trade-offs and synergies between these attributes across different agricultural practices, regions, and land uses, and c) explore novel agri-environmental management practices to assess their role in sustainable floodplain management. Within this manuscript, we explore the benefits that such an approach offers in evaluating sustainable floodplain land use. We found that an interdisciplinary research-based approach demonstrated important benefits such as knowledge transfer, more efficient use of resources (e.g., personnel, funding), and a flexible yet robust research framework. A framework of individual research projects connected to broader interdisciplinary themes allowed a more holistic synthesis of the floodplain systems and assessment of agri-environmental practices. By implicitly considering spatial and social scales, we conceptualised not just how redistribution of the land use types can meet sustainable management objectives, but also explored how compromises within existing uses can optimise socio-economic, agricultural and environmental dimensions and move towards a sustainable multifunctional landscape

The V471A polymorphism in autophagy-related gene ATG7 modifies age at onset specifically in Italian Huntington disease patients

The cause of Huntington disease (HD) is a polyglutamine repeat expansion of more than 36 units in the huntingtin protein, which is inversely correlated with the age at onset of the disease. However, additional genetic factors are believed to modify the course and the age at onset of HD. Recently, we identified the V471A polymorphism in the autophagy-related gene ATG7, a key component of the autophagy pathway that plays an important role in HD pathogenesis, to be associated with the age at onset in a large group of European Huntington disease patients. To confirm this association in a second independent patient cohort, we analysed the ATG7 V471A polymorphism in additional 1,464 European HD patients of the “REGISTRY” cohort from the European Huntington Disease Network (EHDN). In the entire REGISTRY cohort we could not confirm a modifying effect of the ATG7 V471A polymorphism. However, analysing a modifying effect of ATG7 in these REGISTRY patients and in patients of our previous HD cohort according to their ethnic origin, we identified a significant effect of the ATG7 V471A polymorphism on the HD age at onset only in the Italian population (327 patients). In these Italian patients, the polymorphism is associated with a 6-years earlier disease onset and thus seems to have an aggravating effect. We could specify the role of ATG7 as a genetic modifier for HD particularly in the Italian population. This result affirms the modifying influence of the autophagic pathway on the course of HD, but also suggests population-specific modifying mechanisms in HD pathogenesis

Identification of genetic variants associated with Huntington's disease progression: a genome-wide association study

Background Huntington's disease is caused by a CAG repeat expansion in the huntingtin gene, HTT. Age at onset has been used as a quantitative phenotype in genetic analysis looking for Huntington's disease modifiers, but is hard to define and not always available. Therefore, we aimed to generate a novel measure of disease progression and to identify genetic markers associated with this progression measure. Methods We generated a progression score on the basis of principal component analysis of prospectively acquired longitudinal changes in motor, cognitive, and imaging measures in the 218 indivduals in the TRACK-HD cohort of Huntington's disease gene mutation carriers (data collected 2008–11). We generated a parallel progression score using data from 1773 previously genotyped participants from the European Huntington's Disease Network REGISTRY study of Huntington's disease mutation carriers (data collected 2003–13). We did a genome-wide association analyses in terms of progression for 216 TRACK-HD participants and 1773 REGISTRY participants, then a meta-analysis of these results was undertaken. Findings Longitudinal motor, cognitive, and imaging scores were correlated with each other in TRACK-HD participants, justifying use of a single, cross-domain measure of disease progression in both studies. The TRACK-HD and REGISTRY progression measures were correlated with each other (r=0·674), and with age at onset (TRACK-HD, r=0·315; REGISTRY, r=0·234). The meta-analysis of progression in TRACK-HD and REGISTRY gave a genome-wide significant signal (p=1·12 × 10−10) on chromosome 5 spanning three genes: MSH3, DHFR, and MTRNR2L2. The genes in this locus were associated with progression in TRACK-HD (MSH3 p=2·94 × 10−8 DHFR p=8·37 × 10−7 MTRNR2L2 p=2·15 × 10−9) and to a lesser extent in REGISTRY (MSH3 p=9·36 × 10−4 DHFR p=8·45 × 10−4 MTRNR2L2 p=1·20 × 10−3). The lead single nucleotide polymorphism (SNP) in TRACK-HD (rs557874766) was genome-wide significant in the meta-analysis (p=1·58 × 10−8), and encodes an aminoacid change (Pro67Ala) in MSH3. In TRACK-HD, each copy of the minor allele at this SNP was associated with a 0·4 units per year (95% CI 0·16–0·66) reduction in the rate of change of the Unified Huntington's Disease Rating Scale (UHDRS) Total Motor Score, and a reduction of 0·12 units per year (95% CI 0·06–0·18) in the rate of change of UHDRS Total Functional Capacity score. These associations remained significant after adjusting for age of onset. Interpretation The multidomain progression measure in TRACK-HD was associated with a functional variant that was genome-wide significant in our meta-analysis. The association in only 216 participants implies that the progression measure is a sensitive reflection of disease burden, that the effect size at this locus is large, or both. Knockout of Msh3 reduces somatic expansion in Huntington's disease mouse models, suggesting this mechanism as an area for future therapeutic investigation

La tournée forêt méditerranéenne en Corse

International audienceDécrit successivement : la forêt de chênes verts de la vallée du Fango, les différents étages de végétation de Porto à Corte, la gestion forestière en site classé (Restonica), l'agrosylvopastoralisme (SIVOM Venaco), la chaufferie de Corte, la sylviculture en forêt de Ghisoni, et les lotissements en bois de Sperone

L'exploitation Du Roseau

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The food system approach in agroecology supported by natural and social sciences : topics, concepts, applications

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