Characteristics of Clinical and Imaging Findings of Epidermoid Cysts under the Skin of the Mental Region

Epidermoid cyst often arises in the fl oor of oral cavity; however, it is relatively rare to arise subcutaneously in the mental region. We reported characteristics of clinical and imaging fi ndings of epidermoid cysts under the skin of the mental region. The patient was a 53-year-old male. He complained of a subcutaneous mass without pain in the left mental region. A palpable soft and movable thumb-sized mass without pain was observed at the fi rst examination. Ultrasound examination revealed a well-demarcated mass with heterogenous hyper-echoic internal echo and posterior echo enhancement. On power Doppler sonography, a small amount of blood supply was found around the periphery of the mass. Plain CT scan revealeda globular soft-tissue mass with peripheral high and central low CT values area. The mass was removed under local anesthesia using intraoral approach. A histopathologic diagnosis was epidermoid cyst. Recurrence is not observed 2 years after surgery. There were only 3 reports of epidermoid cysts in the mental region, including our case in Japan, clinically characteristics of age ranging 20 to 66 years of age and the mean age of 46 years, with 2 males and 1 female. The size wasfrom 20 mm to 12 mm in diameter and from the tip of a thumb up to the tip of a small fi nger. Ultrasound images of the inside of epidermoid cysts that we experienced this time showed enhancement of relatively uniform hyperechoic image and posterior echo, which was characteristically slightly diff erent from fi ndings of epidermoid cysts generally reported

(MRS)31P Magnetic Resonance Spectroscopy of Perfused Rat Skeletal Muscle

雄ラットの大腿二頭筋のホスホクレアチン(PCr),ATP,無機リン(Pi)および細胞内pH(pHi)を31P-MRSで測定した.遊離筋の灌流中止時にはPCrとpHiは低下し,Piは増加したがATPはほぼ不変であった.灌流再開後,PCrとPiは前値に復帰した.虚血中のpHiの低下はPCrの減少より緩やかであった.PCrが前値の約1/2に減少した時,pHiは下降し始めた.以上は,PCrはラット大腿二頭筋のような典型的な急速収縮筋における虚血早期のpHi緩衝の役割を持っていることを示唆している雄ラットの大腿二頭筋のホスホクレアチン(PCr),ATP,無機リン(Pi)および細胞内pH(pHi)を31P-MRSで測定した.遊離筋の灌流中止時にはPCrとpHiは低下し,Piは増加したがATPはほぼ不変であった.灌流再開後,PCrとPiは前値に復帰した.虚血中のpHiの低下はPCrの減少より緩やかであった.PCrが前値の約1/2に減少した時,pHiは下降し始めた.以上は,PCrはラット大腿二頭筋のような典型的な急速収縮筋における虚血早期のpHi緩衝の役割を持っていることを示唆している雄ラットの大腿二頭筋のホスホクレアチン(PCr),ATP,無機リン(Pi)および細胞内pH(pHi)を31P-MRSで測定した.遊離筋の灌流中止時にはPCrとpHiは低下し,Piは増加したがATPはほぼ不変であった.灌流再開後,PCrとPiは前値に復帰した.虚血中のpHiの低下はPCrの減少より緩やかであった.PCrが前値の約1/2に減少した時,pHiは下降し始めた.以上は,PCrはラット大腿二頭筋のような典型的な急速収縮筋における虚血早期のpHi緩衝の役割を持っていることを示唆している雄ラットの大腿二頭筋のホスホクレアチン(PCr),ATP,無機リン(Pi)および細胞内pH(pHi)を31P-MRSで測定した.遊離筋の灌流中止時にはPCrとpHiは低下し,Piは増加したがATPはほぼ不変であった.灌流再開後,PCrとPiは前値に復帰した.虚血中のpHiの低下はPCrの減少より緩やかであった.PCrが前値の約1/2に減少した時,pHiは下降し始めた.以上は,PCrはラット大腿二頭筋のような典型的な急速収縮筋における虚血早期のpHi緩衝の役割を持っていることを示唆してい

Permanent relief from intermittent cold stress-induced fibromyalgia-like abnormal pain by repeated intrathecal administration of antidepressants

<p>Abstract</p> <p>Background</p> <p>Fibromyalgia (FM) is characterized by chronic widespread pain, which is often refractory to conventional painkillers. Numerous clinical studies have demonstrated that antidepressants are effective in treating FM pain. We previously established a mouse model of FM-like pain, induced by intermittent cold stress (ICS).</p> <p>Results</p> <p>In this study, we find that ICS exposure causes a transient increase in plasma corticosterone concentration, but not in anxiety or depression-like behaviors. A single intrathecal injection of an antidepressant, such as milnacipran, amitriptyline, mianserin or paroxetine, had an acute analgesic effect on ICS-induced thermal hyperalgesia at post-stress day 1 in a dose-dependent manner. In addition, repeated daily antidepressant treatments during post-stress days 1-5 gradually reversed the reduction in thermal pain threshold, and this recovery was maintained for at least 7 days after the final treatment. In addition, relief from mechanical allodynia, induced by ICS exposure, was also observed at day 9 after the cessation of antidepressant treatment. In contrast, the intravenous administration of these antidepressants at conventional doses failed to provide relief.</p> <p>Conclusions</p> <p>These results suggest that the repetitive intrathecal administration of antidepressants permanently cures ICS-induced FM pain in mice.</p

地域連携企画を振り返って

地域連携企画第4弾「平野をさぐる」（大阪市平野区、2008年10月5日・26日）補助事業　文部科学省私立大学学術研究高度化推進事業オープン・リサーチ・センター整備事業（平成17年度～平成21年度）なにわ・大阪文化遺産の総合人文学的研

Candida albicans

Genotypes of Candida spp. isolated from exhalation of 20 dolphins, 11 water samples from captive pools, and 24 oral cavities of staff members in an aquarium using a combination of multiple drug resistance 1 gene (MDR1) and the internal transcribed spacer (ITS) 1 5.8s-ITS 2 regions of ribosomal RNA gene (ITS rDNA) sequences were studied. The holding ratios of the dolphins, captive pools, and staff members were 70, 90, and 29%, respectively. Isolated pathogenic yeast species common to the dolphins and environments were Candida albicans and C. tropicalis. Identical genotypes in both Candida spp. based on the combination of MDR1 and ITSrDNA were found in some dolphins, between a dolphin and a staff, among dolphins and environments, and among environments. The results indicated the diffusion and exchange of pathogenic yeasts at the aquarium among dolphins and environments. The isolates at the aquarium showed higher rates of resistance to azole antifungals compared to reference isolates

A case of intramuscular lipoma of the left buccal region

We report a case of intramuscular lipoma of the left buccal region, along with a review of the relevant literature. Magnetic resonance imaging showed a spindle–shaped mass extending from the canine region to the anterior portion of the masseter muscle in the buccal–alveolar portion of the left mandible. The inner part was visualized as homogeneous high–signal intensity on both T1– and T2–weighted images, and a partial linear region with the same signal intensity as muscle was also observed. The removed tumor measured 35×40×15mm in size, and histopathological findings showed an intramuscular lipoma composed of adipose, muscle and connective tissues. Intramuscular lipomas account for 1.7%–2% of all lipomas, and they very rarely occur in the oral and maxillofacial region. Twenty–three cases with intramuscular lipomas in the oral and maxillofacial region, including our case, have been reported in Japan. The postoperative healing process is generally good. We followed–up our patient after explaining to him the importance of careful, long–term follow–up. It has been only 2 months, to date, since surgery but the outcome appears to be good