Topiramate-associated acute glaucoma in a migraine patient receiving concomitant citalopram therapy: a case-report

We describe the case of a 34 year-old man with diagnosis of migraine with and without aura that developed myopia and acute glaucoma after 7 days of treatment with topiramate. The patient had also been taking citalopram daily for two months. Both topiramate and citalopram have been related to the increase of intraocular pressure and the development of glaucoma. We can't exclude that in this patient citalopram caused an increase of the ocular pressure in dose-dependent manner, facilitating topiramate-induced glaucoma. We recommend to pay particular attention in prescribing of topiramate in migraine patients who are already under treatment with citalopram or other antidepressants with a similar mechanisms of action

The effects of thymoxamine on guinea pig ileum contractions

The effects of thymoxamine on the contractions induced in guinea pig isolated ileum were examined. The drug was tested in a large range of concentrations (10-8-10-4 M). The twitch response induced by acetylcholine was potentiated by low concentrations and inhibited by high concentrations of the α-blocking drug thymoxamine. The contractions in response to carbachol were always inhibited. Thymoxamine also affected the responses of the ileum to other stimulants: angiotensin, pentagastrin, cholecystokinin. The drug (8 x 10-5, 5 x 10-4 M) inhibited the calcium contraction of high K+ depolarized preparation

EFFETTI STIMOLANTI DA DANTROLENE SODICO SU ORGANI E MUSCOLATURA LISCIA.

The effects of sodium dantrolene (DaNa), a calcium antagonist specifically acting on skeletal muscles, were evaluated on the spontaneous contractions of ileum, uterine horns and longitudinal strips of esophageal smooth muscle, in vitro. DaNa (1.81 to 15 μg/ml) caused a reversible dose-related increase of the spontaneous contractions of the three organs. DaNa (15 μg/ml) caused a 60±3% increase of the ileum spontaneous tone, and caused a 57±3% increase in the frequency of the spontaneous contractions of the uterus. The stimulatory effect of DaNa on the uterine musculature was not antagonized by atropine, methysergide or indomethacin. In the esophagus the maximum increase of the spontaneous tone and contractions (65±2%) was due to 3.7 μg/ml perfusion of DaNa. This effect was antagonized by nifedipin

THE INFLUENCE OF INACTIVITY ON MEMBRANE RESTING CONDUCTANCES OF RAT SKELETAL MUSCLE FIBERS UNDERGOING REINNERVATION.

The role of activity in the maintenance of the normal component resting conductances of skeletal muscle fibres has been evaluated in vitro in rat extensor digitorum longus muscle during reinnervation from 2 to 40 days (a) after crushing of the peroneus nerve and (b) after local application of tetrodotoxin (TTX) to the crushed nerve. Whereas membrane conductances were regained after crushing alone, they were not completely restored when impulse propagation was blocked with TTX. It is concluded that nerve trophic factors are of primary importance in the control of muscular membrane conductances, and that transmission at the endplate and the muscle usage triggered by it have a minor but significant effec