8,065 research outputs found
Understanding Group Cohesion and Self-Advocacy in Student Leaders
The purpose of this study is to understand what compels student leaders to advocate for others or for themselves in groups. The data will be gathered through surveys and personal reflections. The study will better our understanding of motivations for advocacy, and reveal empowerment strategies for self-advocacy
Fluorescence Near-Field Microscopy of DNA at Sub-10 nm Resolution
We demonstrate apertureless near-field microscopy of single molecules at sub-10 nm resolution. With a novel phase filter, near-field images of single organic fluorophores were obtained with ~sixfold improvement in the signal-to-noise ratio. The improvement allowed pairs of molecules separated by ~15 nm to be reliably and repeatedly resolved, thus demonstrating the first true Rayleigh resolution test for near-field images of single molecules. The potential of this technique for biological applications was demonstrated with an experiment that measured the helical rise of A-form DNA
Bridging the Usability Gap: Theoretical and Methodological Advances for Spectral Learning of Hidden Markov Models
The Baum-Welch (B-W) algorithm is the most widely accepted method for
inferring hidden Markov models (HMM). However, it is prone to getting stuck in
local optima, and can be too slow for many real-time applications. Spectral
learning of HMMs (SHMMs), based on the method of moments (MOM) has been
proposed in the literature to overcome these obstacles. Despite its promises,
asymptotic theory for SHMM has been elusive, and the long-run performance of
SHMM can degrade due to unchecked propogation of error. In this paper, we (1)
provide an asymptotic distribution for the approximate error of the likelihood
estimated by SHMM, and (2) propose a novel algorithm called projected SHMM
(PSHMM) that mitigates the problem of error propogation, and (3) develop online
learning variantions of both SHMM and PSHMM that accommodate potential
nonstationarity. We compare the performance of SHMM with PSHMM and estimation
through the B-W algorithm on both simulated data and data from real world
applications, and find that PSHMM not only retains the computational advantages
of SHMM, but also provides more robust estimation and forecasting
Fluorescence near-field microscopy of DNA at Sub-10A nm resolution
Journal ArticleWe demonstrate apertureless near-field microscopy of single molecules at sub-10 nm resolution. With a novel phase filter, near-field images of single organic fluorophores were obtained with ~sixfold improvement in the signal-to-noise ratio. The improvement allowed pairs of molecules separated by ~15 nm to be reliably and repeatedly resolved, thus demonstrating the first true Rayleigh resolution test for near-field images of single molecules. The potential of this technique for biological applications was demonstrated with an experiment that measured the helical rise of A-form DNA
CoCoA: A General Framework for Communication-Efficient Distributed Optimization
The scale of modern datasets necessitates the development of efficient
distributed optimization methods for machine learning. We present a
general-purpose framework for distributed computing environments, CoCoA, that
has an efficient communication scheme and is applicable to a wide variety of
problems in machine learning and signal processing. We extend the framework to
cover general non-strongly-convex regularizers, including L1-regularized
problems like lasso, sparse logistic regression, and elastic net
regularization, and show how earlier work can be derived as a special case. We
provide convergence guarantees for the class of convex regularized loss
minimization objectives, leveraging a novel approach in handling
non-strongly-convex regularizers and non-smooth loss functions. The resulting
framework has markedly improved performance over state-of-the-art methods, as
we illustrate with an extensive set of experiments on real distributed
datasets
Tip-Enhanced Fluorescence Microscopy at 10 Nanometer Resolution
We demonstrate unambiguously that the field enhancement near the apex of a laser-illuminated silicon tip decays according to a power law that is moderated by a single parameter characterizing the tip sharpness. Oscillating the probe in intermittent contact with a semiconductor nanocrystal strongly modulates the fluorescence excitation rate, providing robust optical contrast and enabling excellent background rejection. Laterally encoded demodulation yields images with <10 nm spatial resolution, consistent with independent measurements of tip sharpness
Sex differences in exercise-induced diaphragmatic fatigue in endurance-trained athletes
There is evidence that female athletes may be more susceptible to exercise-induced arterial hypoxemia and expiratory flow limitation and have greater increases in operational lung volumes during exercise relative to men. These pulmonary limitations may ultimately lead to greater levels of diaphragmatic fatigue in women. Accordingly, the purpose of this study was to determine whether there are sex differences in the prevalence and severity of exercise-induced diaphragmatic fatigue in 38 healthy endurance-trained men (n = 19; maximal aerobic capacity = 64.0 ± 1.9 ml·kg–1·min–1) and women (n = 19; maximal aerobic capacity = 57.1 ± 1.5 ml·kg–1·min–1). Transdiaphragmatic pressure (Pdi) was calculated as the difference between gastric and esophageal pressures. Inspiratory pressure-time products of the diaphragm and esophagus were calculated as the product of breathing frequency and the Pdi and esophageal pressure time integrals, respectively. Cervical magnetic stimulation was used to measure potentiated Pdi twitches (Pdi,tw) before and 10, 30, and 60 min after a constant-load cycling test performed at 90% of peak work rate until exhaustion. Diaphragm fatigue was considered present if there was a 15% reduction in Pdi,tw after exercise. Diaphragm fatigue occurred in 11 of 19 men (58%) and 8 of 19 women (42%). The percent drop in Pdi,tw at 10, 30, and 60 min after exercise in men (n = 11) was 30.6 ± 2.3, 20.7 ± 3.2, and 13.3 ± 4.5%, respectively, whereas results in women (n = 8) were 21.0 ± 2.1, 11.6 ± 2.9, and 9.7 ± 4.2%, respectively, with sex differences occurring at 10 and 30 min (P < 0.05). Men continued to have a reduced contribution of the diaphragm to total inspiratory force output (pressure-time product of the diaphragm/pressure-time product of the esophagus) during exercise, whereas diaphragmatic contribution in women changed very little over time. The findings from this study point to a female diaphragm that is more resistant to fatigue relative to their male counterparts
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