5,420 research outputs found
A time-domain veto for binary inspirals search
We describe a test to distinguish between actual gravitational waves from binary inspiral and false noise triggers. The test operates in the time domain, and considers the time evolution of the correlator and its statistical distribution. It should distinguish true versus noisy events with the same signal-to-noise ratio and chi-square frequency distribution. A similar test has been applied to S1 LIGO data
Can an ethical revival of prudence within prudential regulation tackle corporate psychopathy?
The view that corporate psychopathy played a significant role in causing the global financial crisis, although insightful, paints a reductionist picture of what we present as the broader issue. Our broader issue is the tendency for psychopathy, narcissism and Machiavellianism to cluster psychologically and culturally as âdark leadershipâ within global financial institutions. Strong evidence for their co-intensification across society and in corporations ought to alarm financial regulators. We argue that an âethical revivalâ of prudence within prudential regulation ought to be included in any package of solutions. Referencing research on moral muteness and the role of language in framing thoughts and behaviours, we recommend that regulators define prudence in an explicitly normative sense, an approach that may be further strengthened by drawing upon a widely appealing ethic of intergenerational care. An ethical revival of prudence, we argue, would allow the core problems of greed and myopia highlighted by corporate psychopathy theory to be addressed in a politically sensitive manner which recognises the pitfalls of regulating directly against corporate psychopathy. Furthermore, it would provide a viable conceptual framework to guide regulators along the treacherous path to more intrusive cultural regulation
Adaptive spectral identification techniques in presence of undetected non linearities
The standard procedure for detection of gravitational wave coalescing
binaries signals is based on Wiener filtering with an appropriate bank of
template filters. This is the optimal procedure in the hypothesis of addictive
Gaussian and stationary noise. We study the possibility of improving the
detection efficiency with a class of adaptive spectral identification
techniques, analyzing their effect in presence of non stationarities and
undetected non linearities in the noiseComment: 4 pages, 2 figures, uses ws-procs9x6.cls Proceedings of "Non linear
physics: theory and experiment. II", Gallipoli (Lecce), 200
Reasoning About a Service-oriented Programming Paradigm
This paper is about a new way for programming distributed applications: the
service-oriented one. It is a concept paper based upon our experience in
developing a theory and a language for programming services. Both the
theoretical formalization and the language interpreter showed us the evidence
that a new programming paradigm exists. In this paper we illustrate the basic
features it is characterized by
Population Genetic-Based Pharmacokinetic Modeling of Methadone and its Relationship with the QTc Interval in Opioid-Dependent Patients.
Methadone is a Ό-opioid agonist widely used for the treatment of pain, and for detoxification or maintenance treatment in opioid addiction. It has been shown to exhibit large pharmacokinetic variability and concentration-QTc relationships. In this study we investigated the relative influence of genetic polymorphism and other variables on the dose concentration-QTc relationship.
A population model for methadone enantiomers in 251 opioid-dependent patients was developed using non-linear mixed effect modeling (NONMEM(Âź)). Various models were tested to characterize the pharmacokinetics of (R)- and (S)-methadone and the pharmacokinetic-pharmacodynamic relationship, while including demographics, physiological conditions, co-medications, and genetic variants as covariates. Model-based simulations were performed to assess the relative increase in QTc with dose upon stratification according to genetic polymorphisms involved in methadone disposition.
A two-compartment model with first-order absorption and lag time provided the best model fit for (R)- and (S)-methadone pharmacokinetics. (S)-methadone clearance was influenced by cytochrome P450 (CYP) 2B6 activity, ABCB1 3435C>T, and α-1 acid glycoprotein level, while (R)-methadone clearance was influenced by CYP2B6 activity, POR*28, and CYP3A4*22. A linear model described the methadone concentration-QTc relationship, with a mean QTc increase of 9.9 ms and 19.2 ms per 1000 ng/ml of (R)- and (S)-methadone, respectively. Simulations with different methadone doses up to 240 mg/day showed that <8 % of patients presented with a QTc interval above 450 ms; however, this might reach 12 to 18 % for (R)- and (S)-methadone, respectively, in patients with a genetic status associated with a decreased methadone elimination at doses exceeding 240 mg/day.
Risk factor assessment, electrocardiogram monitoring, and therapeutic drug monitoring are beneficial to optimize treatment in methadone patients, especially for those who have low levels despite high methadone doses, or who are at risk of overdosing
A model for the interaction of high-energy particles in straight and bent crystals implemented in Geant4
A model for the simulation of orientational effects in straight and bent
periodic atomic structures is presented. The continuum potential approximation
has been adopted.The model allows the manipulation of particle trajectories by
means of straight and bent crystals and the scaling of the cross sections of
hadronic and electromagnetic processes for channeled particles. Based on such a
model, an extension of the Geant4 toolkit has been developed. The code has been
validated against data from channeling experiments carried out at CERN
Low-latency analysis pipeline for compact binary coalescences in the advanced gravitational wave detector era
The multi-band template analysis (MBTA) pipeline is a low-latency coincident
analysis pipeline for the detection of gravitational waves (GWs) from compact
binary coalescences. MBTA runs with a low computational cost, and can identify
candidate GW events online with a sub-minute latency. The low computational
running cost of MBTA also makes it useful for data quality studies. Events
detected by MBTA online can be used to alert astronomical partners for
electromagnetic follow-up. We outline the current status of MBTA and give
details of recent pipeline upgrades and validation tests that were performed in
preparation for the first advanced detector observing period. The MBTA pipeline
is ready for the outset of the advanced detector era and the exciting prospects
it will bring.Comment: 18 pages, 10 figure
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