Interpreting the Hours-Technology time-varying relationship

We investigate the time varying relation between hours and technology shocks using a structural business cycle model. We propose an RBC model with a Constant Elasticity of Substitution (CES) production function that allows for capital- and labor-augmenting technology shocks. We estimate the model with Bayesian techniques. In the full sample, we find (i) evidence in favor of a less than unitary elasticity of substitution (rejecting Cobb-Douglas) and (ii) a sizable role for capital augmenting shock for business cycles fluctuations. In rolling sub-samples, we document that the transmission of technology shocks to hours worked has been varying over time. We argue that this change is due to the increase of the elasticity of factor substitution. That is, labor and capital became less complementary throughout the sample inducing a change in the sign and size of the response of hours. We conjecture that this change may have been induced by a change in the skill composition of the labor input.Hours Worked and Business Cycles, Bayesian Methods.

Investigating The Physics Case of Running a B-Factory at the Y(5S) Resonance

We discuss the physics case of a high luminosity B-Factory running at the Y(5S) resonance. We show that the coherence of the B meson pairs is preserved at this resonance, and that Bs can be well distinguished from Bd and charged B mesons. These facts allow to cover the physics program of a traditional B-Factory and, at the same time, to perform complementary measurements which are not accessible at the Y(4S). In particular we show how, despite the experimental limitations in performing time-dependent measurements of Bs decays, the same experimental information can be extracted, in several cases, from the determination of time-integrated observables. In addition, a few examples of the potentiality in measuring rare Bs decays are given. Finally, we discuss how the study of Bs meson will improve the constraints on New Physics parameters in the Bs sector, in the context of the generalized Unitarity Triangle analysis.Comment: 47 pages, 22 figure

Environmental impact assessment of renewable energy communities: the analysis of an Italian neighbourhood

In recent years, research in renewable energy community (REC) schemes, coupling renewable energy sources and building energy efficiency, is gaining momentum. In this context, Urban Building Energy Modelling tools (UBEMs) have proved to comply with the design requirements of such schemes. However, a clear methodology exploiting UBEMs to support the design of RECs is still missing, especially for assessing the greenhouse gas (GHG) emissions associated with their specific technical configuration. Here, the REC is modelled in “urban modeling interface” (umi), one of the main bottom-up physics-based UBEMs. A building archetype approach is exploited to model the scenarios and assess embodied GHG emissions. The proposed methdology gives the possibility to investigate both the embodied and operational emissions for different REC configuration. A residential neighbourhood in Italy is selected as case study. The results demonstrate the importance of considering building characteristics when analysing emissions reductions in energy-sharing schemes, underlining the necessity of coupling the REC design with energy retrofit interventions

Single-channel analysis of a ClC-2-like chloride conductance in cultured rat cortical astrocytes

AbstractThe single-channel behavior of the hyperpolarization-activated, ClC-2-like inwardly rectifying Cl− current (IClh), induced by long-term dibutyryl-cyclic-AMP-treated cultured cortical rat astrocytes, was analyzed with the patch-clamp technique. In outside-out patches in symmetrical 144 mM Cl− solutions, openings of hyperpolarization-activated small-conductance Cl− channels revealed burst activity of two equidistant conductance levels of 3 and 6 pS. The unitary openings displayed slow activation kinetics. The probabilities of the closed and conducting states were consistent with a double-barrelled structure of the channel protein. These results suggest that the astrocytic ClC-2-like Cl− current IClh is mediated by a small-conductance Cl− channel, which has the same structural motif as the Cl− channel prototype ClC-0

Particle Number Fluctuations in Statistical Model with Exact Charge Conservation Laws

Even though the first momenta i.e. the ensemble average quantities in canonical ensemble (CE) give the grand canonical (GC) results in large multiplicity limit, the fluctuations involving second moments do not respect this asymptotic behaviour. Instead, the asymptotics are strikingly different, giving a new handle in study of statistical particle number fluctuations in relativistic nuclear reactions. Here we study the analytical large volume asymptotics to general case of multispecies hadron gas carrying fixed baryon number, strangeness and electric charge. By means of Monte Carlo simulations we have also studied the general multiplicity probability distributions taking into account the decay chains of resonance states.Comment: 4 pages, 2 figures. The report of the talk given in Strangeness in Quark Matter 2004, Cape Town. Submitted to J. Phys. G: Nucl. Part. Phy

Thromboembolic events in patients treated with anti-angiogenic drugs

Induction of neo-angiogenesis is a fundamental step in many pathological conditions. The therapeutic value of inhibiting angiogenesis is an interesting area of research in oncology, with vascular endothelial growth factor (VEGF) being the most suitable anti-angiogenic target. In the last decade a number of anti-VEGF drugs have demonstrated, especially in combination with standard chemotherapy, clinical efficacy in the treatment of different solid tumor types. As data from clinical trials on anti-VEGF drugs are becoming available, it is increasingly recognized that VEGF, in addition to being a permeability, proliferation, and migration factor, is also a maintenance and protection factor for endothelial cells, being capable of regulating multiple biological functions, i.e. the production of vasoactive mediators and the expression of components of the thrombolytic and coagulation pathways. Consequently, the disturbance of vascular homeostasis by blocking VEGF may lead to endothelial dysfunction and adverse vascular effects, such as venous and arterial thromboembolic events. In preclinical models angiogenesis and the increased expression of VEGF has been associated to altered expression of proinflammatory genes. These genes may be regulated in a biphasic manner, and it is possible that anti-VEGF therapy may disrupt a negative feedback loop that leads to potential in situ thrombus formation. Accordingly, combination treatment with bevacizumab and chemotherapy, compared with chemotherapy alone, was recently associated with an increased risk of thromboembolism. The present review considers the biological mechanisms and clinical impact of thromboembolic complications during anti-angiogenic treatments in cancer patients

Dynamic expression of homeostatic ion channels in differentiated cortical astrocytes in vitro

The capacity of astrocytes to adapt their biochemical and functional features upon physiological and pathological stimuli is a fundamental property at the basis of their ability to regulate the homeostasis of the central nervous system (CNS). It is well known that in primary cultured astrocytes, the expression of plasma membrane ion channels and transporters involved in homeostatic tasks does not closely reflect the pattern observed in vivo. The individuation of culture conditions that promote the expression of the ion channel array found in vivo is crucial when aiming at investigating the mechanisms underlying their dynamics upon various physiological and pathological stimuli. A chemically defined medium containing growth factors and hormones (G5) was previously shown to induce the growth, differentiation, and maturation of primary cultured astrocytes. Here we report that under these culture conditions, rat cortical astrocytes undergo robust morphological changes acquir- ing a multi-branched phenotype, which develops gradually during the 2-week period of culturing. The shape changes were paralleled by variations in passive membrane properties and background conductance owing to the differential temporal development of inwardly rectifying chloride (Cl−) and potassium (K+) currents. Confocal and immunoblot analyses showed that morphologically differentiated astrocytes displayed a large increase in the expression of the inward rectifier Cl− and K+ channels ClC-2 and Kir4.1, respectively, which are relevant ion channels in vivo. Finally, they exhibited a large diminution of the intermediate filaments glial fibrillary acidic protein (GFAP) and vimentin which are upregulated in reactive astrocytes in vivo. Taken together the data indicate that long-term culturing of cortical astrocytes in this chemical-defined medium promotes a quiescent functional phenotype. This culture model could aid to address the regulation of ion channel expression involved in CNS homeostasis in response to physiological and pathological challenge

Computational Fluid Dynamics of Reacting Flows at Surfaces: Methodologies and Applications

This review presents the numerical algorithms and speed-up strategies developed to couple continuum macroscopic simulations and detailed microkinetic models in the context of multiscale approaches to chemical reactions engineering. CFD simulations and hierarchical approaches are discussed both for fixed and fluidized systems. The foundations of the methodologies are reviewed together with specific examples to show the applicability of the methods. These concepts play a pivotal role to enable the first-principles multiscale approach to systems of technological relevance

The Emerging Trends of Renewable Energy Communities’ Development in Italy

Increasing concerns over climate change and energy poverty have triggered the transition toward a decentralized energy system through the widespread adoption of renewable energy technologies. Although this transition was led, over past decades, mainly by major investors and large industrial players, citizens and local authorities are increasingly playing an active role in delivering clean energy investments. In particular, the current European Renewable Energy Directive introduced Renewable Energy Communities (RECs), which allow citizens to collectively organize their participation in the energy market, leading to a more distributed renewable energy system and new forms of sustainable, collaborative, and democratic economies. RECs currently under implementation show differences among European countries due to the different national contexts. A literature review exploring the peculiar Italian regulatory framework on RECs and its recent evolution has been carried out to identify available national and regional financial support mechanisms, barriers, and emerging trends in the diffusion of RECs across the country. The paper reviews and describes three main approaches that emerged in the development of RECs in Italy, discussing their strengths, and limitations. In addition, it provides a brief comparison of the regulatory framework in different European countries, highlighting the distinctive features of the Italian experience. Although the development of RECs in Italy involved a combination of both public and private initiatives, the leading role of local authorities as promoters and aggregators of RECs is evident. This role helps preserve the social impact of RECs but might slow down their implementation due to bureaucratic issues often linked to public procedures and procurement processes, as well as the lack of sufficient expertise within local authorities