Clinical characteristics and comparison of the effectiveness of methods of treatment of women stress urinary incontinence

The article analyzes two main methods of surgical treatment of women stress urinary incontinence: urethropecia synthetic loop and less invasive intervention – the introduction of a volume-forming gel in the paraurethral tissue for clinical comparison against a number of criteria.В статье проанализированы две основные методики хирургического лечения стрессового недержания мочи у женщин: уретропексия синтетической петлёй, а также менее инвазивное вмешательство – введениеобъёмообразующего геля в парауретральную клетчатку с целью клинического сравнения их между собой по ряду критериев

Clinical characteristics and comparison of the effectiveness of methods of treatment of women stress urinary incontinence

The article analyzes two main methods of surgical treatment of women stress urinary incontinence: urethropecia synthetic loop and less invasive intervention – the introduction of a volume-forming gel in the paraurethral tissue for clinical comparison against a number of criteria.В статье проанализированы две основные методики хирургического лечения стрессового недержания мочи у женщин: уретропексия синтетической петлёй, а также менее инвазивное вмешательство – введение объёмообразующего геля в парауретральную клетчатку с целью клинического сравнения их между собой по ряду критериев

Hall Normalization Constants for the Bures Volumes of the n-State Quantum Systems

We report the results of certain integrations of quantum-theoretic interest, relying, in this regard, upon recently developed parameterizations of Boya et al of the n x n density matrices, in terms of squared components of the unit (n-1)-sphere and the n x n unitary matrices. Firstly, we express the normalized volume elements of the Bures (minimal monotone) metric for n = 2 and 3, obtaining thereby "Bures prior probability distributions" over the two- and three-state systems. Then, as an essential first step in extending these results to n > 3, we determine that the "Hall normalization constant" (C_{n}) for the marginal Bures prior probability distribution over the (n-1)-dimensional simplex of the n eigenvalues of the n x n density matrices is, for n = 4, equal to 71680/pi^2. Since we also find that C_{3} = 35/pi, it follows that C_{4} is simply equal to 2^{11} C_{3}/pi. (C_{2} itself is known to equal 2/pi.) The constant C_{5} is also found. It too is associated with a remarkably simple decompositon, involving the product of the eight consecutive prime numbers from 2 to 23. We also preliminarily investigate several cases, n > 5, with the use of quasi-Monte Carlo integration. We hope that the various analyses reported will prove useful in deriving a general formula (which evidence suggests will involve the Bernoulli numbers) for the Hall normalization constant for arbitrary n. This would have diverse applications, including quantum inference and universal quantum coding.Comment: 14 pages, LaTeX, 6 postscript figures. Revised version to appear in J. Phys. A. We make a few slight changes from the previous version, but also add a subsection (III G) in which several variations of the basic problem are newly studied. Rather strong evidence is adduced that the Hall constants are related to partial sums of denominators of the even-indexed Bernoulli numbers, although a general formula is still lackin

Experience of laparoscopic hysterectomy using SILS port

Taking into account the emergence of new techniques SILS (Single Incision Laparoscopic Surgery), there is a need assessment of their advantages. On the basis of the City Clinical Hospital №40 eight hysterectomies were performed in patients with uterine leiomyoma by SILS. As a result, it was found that the operation of the port has a number of advantages: excellent cosmetic effect, and improve quality of life, minimal pain in the postoperative period, the duration of the operation is comparable with standard laparoscopy.С учетом появления новых методик SILS (Single Incision Laparoscopic Surgery), есть необходимость оценки их преимуществ. На базе МАУ ГКБ ЫО нами было проведено 8 гистерэктомий у пациенток с лейомиомой матки методом SILS-порта. В результате было выявлено, что однопортовая хирургия имеет ряд преимуществ: прекрасный косметических эффект, минимальный болевой синдром в послеоперационном периоде, улучшение качества жизни. Продолжительность операции была сопоставима со стандартной лапароскопией

Experience of application of antiadhesive barriers to prevent and treatment of adhesive process in the conditions of the gynecologic hospital

The aim of work is to study possibilities of application of antiadhesive barriers in complex surgical treatment of women with a various gynecologic pathology. Under supervision there were 99 women at whom during surgical treatment antiadhesive barriers were applied. In 69 cases it was used INTERCEED and at 30 patients has been applied INTERCOAT. All patients were divided into 3 groups according to disease: women with an endometriosis (n=41), patients with myoma of uterus (n=20), sterility (n=38). At a final stage of operation antiadhesive barriers were applied. The control laparoscopy is spent to 16 women in 6 months. Adherent process of 1 degree is taped at 7 patients, 2 degrees at 4 women. Thus, application of absorbable adhesion barriers in complex surgical treatment of gynecologic diseases shows high efficiency of preventive maintenance of adhesive process.Цель работы: изучить возможности применения противоспаечных барьеров в комплексном хирургическом лечении женщин с различной гинекологической патологией. Под наблюдением находилось 99 женщин, у которых во время хирургического лечения применялись антиспаечные барьеры. В 69 случаях использовался INTERCEED и у 30 пациенток был применен INTERCOAT. Пациентки разделены на 3 группы с учетом заболевания: женщины с эндометриозом (n=41), миомой матки (n=20), бесплодием (n=38). На конечном этапе операции применялись антиспаечные барьеры. Контрольная лапароскопия проведена 16 женщинам через 6 месяцев. Спаечный процесс 1 степени выявлен у 7 пациенток, 2 степени у 4 женщин. Применение антиспаечных барьеров в комплексном хирургическом лечении гинекологических заболеваний показывает высокую эффективность профилактики спаечного процесса

Posttraumatic Stress Disorder Prevalence and Risk of Recurrence in Acute Coronary Syndrome Patients: A Meta-analytic Review

BACKGROUND:Acute coronary syndromes (ACS; myocardial infarction or unstable angina) can induce posttraumatic stress disorder (PTSD), and ACS-induced PTSD may increase patients' risk for subsequent cardiac events and mortality. OBJECTIVE:To determine the prevalence of PTSD induced by ACS and to quantify the association between ACS-induced PTSD and adverse clinical outcomes using systematic review and meta-analysis. DATA SOURCES:Articles were identified by searching Ovid MEDLINE, PsycINFO, and Scopus, and through manual search of reference lists. METHODOLOGY/PRINCIPAL FINDINGS:Observational cohort studies that assessed PTSD with specific reference to an ACS event at least 1 month prior. We extracted estimates of the prevalence of ACS-induced PTSD and associations with clinical outcomes, as well as study characteristics. We identified 56 potentially relevant articles, 24 of which met our criteria (N = 2383). Meta-analysis yielded an aggregated prevalence estimate of 12% (95% confidence interval [CI], 9%-16%) for clinically significant symptoms of ACS-induced PTSD in a random effects model. Individual study prevalence estimates varied widely (0%-32%), with significant heterogeneity in estimates explained by the use of a screening instrument (prevalence estimate was 16% [95% CI, 13%-20%] in 16 studies) vs a clinical diagnostic interview (prevalence estimate was 4% [95% CI, 3%-5%] in 8 studies). The aggregated point estimate for the magnitude of the relationship between ACS-induced PTSD and clinical outcomes (ie, mortality and/or ACS recurrence) across the 3 studies that met our criteria (N = 609) suggested a doubling of risk (risk ratio, 2.00; 95% CI, 1.69-2.37) in ACS patients with clinically significant PTSD symptoms relative to patients without PTSD symptoms. CONCLUSIONS/SIGNIFICANCE:This meta-analysis suggests that clinically significant PTSD symptoms induced by ACS are moderately prevalent and are associated with increased risk for recurrent cardiac events and mortality. Further tests of the association of ACS-induced PTSD and clinical outcomes are needed

Есть ли связь обмена железа с течением СOVID-19?

The review analyzes possible epidemiological and molecular mechanisms responsible for hyperinflammation in patients with the severe course of COVID-19.Results: it highlights the similarities between this condition and hyperferritinemic syndrome which allows considering pathogenesis of COVID-19 with the direct involvement of iron metabolism. In the case of COVID-19 infection of moderate severity and especially in its severe forms, it is indicated to use of iron chelators and other methods of free iron elimination.Цель: по данным литературы провести анализ возможных эпидемиологических и молекулярных механизмов, ответственных за гипервоспаление у пациентов с тяжелой формой COVID-19, связанных с нарушением метаболизма железа.Результаты: подчеркивается сходство между COVID-19 и гиперферритинемическим синдромом, что позволяет рассматривать патогенез COVID-19 с прямым участием метаболизма железа. Очевидно, что при инфекции COVID-19 средней степени тяжести и особенно при тяжелых формах использование хелаторов железа и других методов элиминации свободного железа имеет обоснованные показания