Non-equilibrium ionization around clouds evaporating in the interstellar medium

It is of prime importance for global models of the interstellar medium to know whether dense clouds do or do not evaporate in the hot coronal gas. The rate of mass exchanges between phases depends very much on that. McKee and Ostriker's model, for instance, assumes that evaporation is important enough to control the expansion of supernova remnants, and that mass loss obeys the law derived by Cowie and McKee. In fact, the geometry of the magnetic field is nearly unknown, and it might totally inhibit evaporation, if the clouds are not regularly connected to the hot gas. Up to now, the only test of the theory is the U.V. observation (by the Copernicus and IUE satellites) of absorption lines of ions such as OVI or NV, that exist at temperatures of a few 100,000 K typical of transition layers around evaporating clouds. Other means of testing the theory are discussed

Sea-level rise along the Emilia-Romagna coast (Northern Italy) in 2100: scenarios and impacts

As a consequence of climate change and land subsidence, coastal zones are directly impacted by sea-level rise. In some particular areas, the effects on the ecosystem and urbanisation are particularly enhanced. We focus on the Emilia-Romagna (E-R) coastal plain in Northern Italy, bounded by the Po river mouth to the north and by the Apennines to the south. The plain is  ∼ 130 km long and is characterised by wide areas below mean sea level, in part made up of reclaimed wetlands. In this context, several morphodynamic factors make the shore and back shore unstable. During next decades, the combined effects of land subsidence and of the sea-level rise as a result of climate change are expected to enhance the shoreline instability, leading to further retreat. The consequent loss of beaches would impact the economy of the region, which is tightly connected with tourism infrastructures. Furthermore, the loss of wetlands and dunes would threaten the ecosystem, which is crucial for the preservation of life and the environment. These specific conditions show the importance of a precise definition of the possible local impacts of the ongoing and future climate variations. The aim of this work is the characterisation of vulnerability in different sectors of the coastal plain and the recognition of the areas in which human intervention is urgently required. The Intergovernmental Panel on Climate Change (IPCC) Fifth Assessment Report (AR5) sea-level scenarios are merged with new high-resolution terrain models, current data for local subsidence and predictions of the flooding model in_CoastFlood in order to develop different scenarios for the impact of sea-level rise projected to year 2100. First, the potential land loss due to the combined effect of subsidence and sea-level rise is extrapolated. Second, the increase in floodable areas as a result of storm surges is quantitatively determined. The results are expected to support the regional mitigation and adaptation strategies designed in response to climate change

Reduction of multidrug-resistant (Mdr) bacterial infections during the covid-19 pandemic: a retrospective study

Multidrug-resistant (MDR) organisms are emerging as some of the main healthcare prob-lems worldwide. During the COVID-19 pandemic, several Infection Prevention and Control (IPC) measures have been adopted to reduce nosocomial microorganism transmission. We performed a case–control study to identify if the incidence of MDR bacterial infections while using pandemic-related preventive measures is lower than in previous years. From 2017 to 2020, we monitored hospital discharges over a four-month period (P #) (1 March to 30 June) in St. Andrea Hospital, Rome. In total, we reported 1617 discharges. Pearson’s chi-squared test was used to identify significant differences. A value of p ≤ 0.05 was considered statistically significant. A significant reduction in the incidence of total MDR bacterial infections was observed during the pandemic compared to in prepandemic years (p < 0.05). We also found a significantly higher incidence of MDR bacterial infections in COVID-19 departments compared with other medical departments (29% and 19%, respectively), with extended-spectrum β-lactamase Klebsiella pneumoniae as the pathogens presenting the highest increase. This study demonstrates that maintaining a high level of preventive measures could help tackle an important health problem such as that of the spread of MDR bacteria

Erratum to: Proximal humeral fractures in elderly patients

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Familial fetal-type rhabdomyoma of the tricuspid valve in the neonate: Malignant course for a benign disease

Familial fetal-type rhabdomyoma of the tricuspid valve in the neonate: malignant course for a benign disease

Detection of serum allergen-specific IgE in atopic dogs tested in northern Italy: Preliminary study

Canine atopic dermatitis (CAD) is a pruritic allergic skin disease associated with IgE-mediated hypersensitivity. IgE is detected using Serum Allergen-Specific IgE test (SAT) in order to identify allergens. The present study aims to identify the environmental allergens in atopic dogs living in Northern Italy using SAT. The screening SAT (sSAT), using a monoclonal antibody cocktail-based ELISA to identify indoor and outdoor allergens, was performed. In all positive samples, an anti-IgE monoclonal antibody ELISA test was performed to extend panel of allergens. Out of 117 selected dogs, 69 were included in the study; 71% were positive and 29% were negative to sSAT. Among the 49 positive sSAT, 53% were positive for both indoor and outdoor, 38.8% only for indoor, and 8.2% only for outdoor allergens. This is the first study on the frequency of allergens involved in CAD in Italy using SAT. IgE hypersensitivity in atopic dogs of Northern Italy is usually associated with indoor allergens, primarily house dust mites. Among the outdoor allergens, an important role was played by Rumex acetosa. Polysensitization also commonly occurs. Therefore, since the numerous factors affect the IgE positivity in CAD, specific panels for geographical areas should be considered and re-evaluated at time intervals

First record of Acanthurus chirurgus (Perciformes: Acanthuridae) in the Mediterranean Sea, with some distributional notes on Mediterranean Acanthuridae

The occurrence of the doctorfish Acanthurus chirurgus is reported for the first time in the Mediterranean Sea, off Elba Island, Tyrrhenian Sea (42.726667° N, 10.434444° E). This record is tentatively related to aquarium release. The occurrence of Acanthuridae in the Mediterranean Sea is briefly reviewed, and some distributional notes on Acanthurus coeruleus and Acanthurus monroviae in the Mediterranean are provided

Diagnosis of focal liver lesions from ultrasound using deep learning

PURPOSE: The purpose of this study was to create an algorithm that simultaneously detects and characterizes (benign vs. malignant) focal liver lesion (FLL) using deep learning. MATERIALS AND METHODS: We trained our algorithm on a dataset proposed during a data challenge organized at the 2018 Journées Francophones de Radiologie. The dataset was composed of 367 two-dimensional ultrasound images from 367 individual livers, captured at various institutions. The algorithm was guided using an attention mechanism with annotations made by a radiologist. The algorithm was then tested on a new data set from 177 patients. RESULTS: The models reached mean ROC-AUC scores of 0.935 for FLL detection and 0.916 for FLL characterization over three shuffled three-fold cross-validations performed with the training data. On the new dataset of 177 patients, our models reached a weighted mean ROC-AUC scores of 0.891 for seven different tasks. CONCLUSION: This study that uses a supervised-attention mechanism focused on FLL detection and characterization from liver ultrasound images. This method could prove to be highly relevant for medical imaging once validated on a larger independent cohort

Implementing quality by design for biotech products: are regulators on track?

Quality by design (QbD) is an innovative approach to drug development that has started to be implemented into the regulatory framework, but currently mainly for chemical drugs. The recent marketing authorization of the first monoclonal antibody developed using extensive QbD concepts in the European Union paves the way for future further regulatory approvals of complex products employing this cutting-edge technological concept. In this paper, we report and comment on insights and lessons learnt from the non-public discussions in the European Medicines Agency's Biologicals Working Party and Committee for Medicinal Products for Human Use on the key issues during evaluation related to the implementation of an extensive QbD approach for biotechnology-derived medicinal products. Sharing these insights could prove useful for future developments in QbD for biotech products in general and monoclonal antibodies in particular